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Spout1 SPOUT domain containing methyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 227695, updated on 5-Mar-2024

Summary

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Official Symbol
Spout1provided by MGI
Official Full Name
SPOUT domain containing methyltransferase 1provided by MGI
Primary source
MGI:MGI:106544
See related
Ensembl:ENSMUSG00000039660 AllianceGenome:MGI:106544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CENP-32; D2Wsu81e; 9930028P05
Summary
Predicted to enable miRNA binding activity. Predicted to be involved in maintenance of centrosome location and production of miRNAs involved in gene silencing by miRNA. Predicted to act upstream of or within cell division and methylation. Predicted to be located in chromosome, centromeric region; cytoplasm; and cytoskeleton. Predicted to be active in kinetochore; mitotic spindle; and spindle pole centrosome. Is expressed in embryo and extraembryonic component. Orthologous to human SPOUT1 (SPOUT domain containing methyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 60.1), limb E14.5 (RPKM 21.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Spout1 in Genome Data Viewer
Location:
2 B; 2 21.29 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (30063458..30068506, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30173446..30178494, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (zinc transporter), member 1, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E7803 Neighboring gene predicted gene, 31080 Neighboring gene STARR-positive B cell enhancer ABC_E2609 Neighboring gene endonuclease G Neighboring gene kynurenine aminotransferase 1 Neighboring gene predicted gene, 31201 Neighboring gene STARR-seq mESC enhancer starr_04089 Neighboring gene STARR-seq mESC enhancer starr_04090 Neighboring gene RIKEN cDNA 1700084E18 gene Neighboring gene STARR-positive B cell enhancer ABC_E7804

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Generation and characterization of endonuclease G null mice. Irvine RA, et al. Mol Cell Biol, 2005 Jan. PMID 15601850, Free PMC Article
  2. Endonuclease G is required for early embryogenesis and normal apoptosis in mice. Zhang J, et al. Proc Natl Acad Sci U S A, 2003 Dec 23. PMID 14663139, Free PMC Article
  3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
  4. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
  5. Isolation of novel tissue-specific genes from cDNA libraries representing the individual tissue constituents of the gastrulating mouse embryo. Harrison SM, et al. Development, 1995 Aug. PMID 7671812

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC90552

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables miRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables miRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in maintenance of centrosome location IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maintenance of centrosome location ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in miRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in miRNA processing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect post-transcriptional regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
is_active_in mitotic spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
is_active_in spindle pole centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle pole centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
putative methyltransferase C9orf114 homolog
Names
centromere protein 32
kinetochore-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172660.4 → NP_766248.3  putative methyltransferase C9orf114 homolog

    See identical proteins and their annotated locations for NP_766248.3

    Status: VALIDATED

    Source sequence(s)
    AK147162, BY289934, BY462424
    Consensus CDS
    CCDS15873.2
    UniProtKB/Swiss-Prot
    Q3UHX9, Q8BQY9
    Related
    ENSMUSP00000097793.5, ENSMUST00000100220.5
    Conserved Domains (1) summary
    pfam02598
    Location:76 → 365
    Methyltrn_RNA_3; Putative RNA methyltransferase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    30063458..30068506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_866012.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NR_030685.1: Suppressed sequence

    Description
    NR_030685.1: This RefSeq was permanently suppressed because the transcript is incompletely processed at its 5'' end.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UHX9.1 GenPept UniProtKB/Swiss-Prot:Q3UHX9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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