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Zer1 zyg-11 related, cell cycle regulator [ Mus musculus (house mouse) ]

Gene ID: 227693, updated on 5-Mar-2024

Summary

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Official Symbol
Zer1provided by MGI
Official Full Name
zyg-11 related, cell cycle regulatorprovided by MGI
Primary source
MGI:MGI:2442511
See related
Ensembl:ENSMUSG00000039686 AllianceGenome:MGI:2442511
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zyg11bl; C230075L19Rik
Summary
Predicted to be involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process and protein quality control for misfolded or incompletely synthesized proteins. Predicted to be part of Cul2-RING ubiquitin ligase complex. Is expressed in central nervous system and retina. Orthologous to human ZER1 (zyg-11 related cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 30.7), thymus adult (RPKM 30.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 B; 2 21.16 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29987295..30016299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30097283..30126287, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene SET nuclear oncogene Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene protein kinase N3 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873 Neighboring gene STARR-seq mESC enhancer starr_04088 Neighboring gene STARR-positive B cell enhancer ABC_E4427 Neighboring gene TBC1 domain family, member 13 Neighboring gene reactive oxygen species modulator 1 pseudogene Neighboring gene solute carrier family 39 (zinc transporter), member 1, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein quality control for misfolded or incompletely synthesized proteins ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein zer-1 homolog
Names
zer-1 homolog
zyg-11 homolog B-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290503.1 → NP_001277432.1  protein zer-1 homolog isoform b

    See identical proteins and their annotated locations for NP_001277432.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BC048924, BC057021, BY749660
    Consensus CDS
    CCDS71017.1
    UniProtKB/TrEMBL
    Q3U297
    Related
    ENSMUSP00000109307.2, ENSMUST00000113677.3
    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  2. NM_178694.4 → NP_848809.2  protein zer-1 homolog isoform a

    See identical proteins and their annotated locations for NP_848809.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC048924, BY749660
    Consensus CDS
    CCDS15870.1
    UniProtKB/Swiss-Prot
    A2BEA2, Q6PGH5, Q80ZJ6, Q8BG38
    Related
    ENSMUSP00000046441.9, ENSMUST00000044751.14
    Conserved Domains (3) summary
    cd00020
    Location:529 → 655
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:575 → 613
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    29987295..30016299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317305.3 → XP_017172794.1  protein zer-1 homolog isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  2. XM_036160810.1 → XP_036016703.1  protein zer-1 homolog isoform X3

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:560 → 598
    ARM; armadillo repeat [structural motif]

  3. XM_006497928.5 → XP_006497991.1  protein zer-1 homolog isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  4. XM_036160808.1 → XP_036016701.1  protein zer-1 homolog isoform X2

    UniProtKB/TrEMBL
    Q3U297
    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  5. XM_017317313.3 → XP_017172802.1  protein zer-1 homolog isoform X1

    Conserved Domains (2) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
    sd00043
    Location:562 → 600
    ARM; armadillo repeat [structural motif]

  6. XM_017317318.2 → XP_017172807.1  protein zer-1 homolog isoform X4

    Conserved Domains (1) summary
    sd00034
    Location:82 → 104
    LRR_AMN1; leucine-rich repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZJ6.1 GenPept UniProtKB/Swiss-Prot:Q80ZJ6

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