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Ddx31 DEAD/H box helicase 31 [ Mus musculus (house mouse) ]

Gene ID: 227674, updated on 11-Apr-2024

Summary

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Official Symbol
Ddx31provided by MGI
Official Full Name
DEAD/H box helicase 31provided by MGI
Primary source
MGI:MGI:2682639
See related
Ensembl:ENSMUSG00000026806 AllianceGenome:MGI:2682639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm997; 5830444G11Rik
Summary
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Predicted to be involved in ribosome biogenesis. Predicted to be located in Golgi apparatus and nucleolus. Predicted to be active in nucleus. Orthologous to human DDX31 (DEAD-box helicase 31). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 3.9), limb E14.5 (RPKM 3.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 19.38 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (28730418..28795587)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (28840406..28905575)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene adenylate kinase 8 Neighboring gene microRNA 3088 Neighboring gene STARR-seq mESC enhancer starr_04033 Neighboring gene high mobility group box 3 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E10088 Neighboring gene general transcription factor IIIC, polypeptide 4 Neighboring gene BarH like homeobox 1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evolutionary plasticity of segmentation clock networks. Krol AJ, et al. Development, 2011 Jul. PMID 21652651, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in ribosome biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable ATP-dependent RNA helicase DDX31
Names
DEAD box protein 31
DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 31
NP_001028466.2
XP_030105674.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033294.3 → NP_001028466.2  probable ATP-dependent RNA helicase DDX31

    See identical proteins and their annotated locations for NP_001028466.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein-coding transcript.
    Source sequence(s)
    AL732526, BC066017
    Consensus CDS
    CCDS15848.1
    UniProtKB/Swiss-Prot
    A2AIT3, A3KMM3, Q3TLT4, Q6NZQ2
    Related
    ENSMUSP00000109484.3, ENSMUST00000113853.3
    Conserved Domains (4) summary
    PRK04837
    Location:105 → 553
    PRK04837; ATP-dependent RNA helicase RhlB; Provisional
    cd00079
    Location:347 → 495
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam13959
    Location:557 → 618
    DUF4217; Domain of unknown function (DUF4217)
    cl21455
    Location:105 → 317
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RNA

  1. NR_156412.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate exon and uses an alternate splice junction compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL732526

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    28730418..28795587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249814.2 → XP_030105674.1  probable ATP-dependent RNA helicase DDX31 isoform X1

    Conserved Domains (2) summary
    COG0513
    Location:1 → 373
    SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
    pfam13959
    Location:344 → 405
    DUF4217; Domain of unknown function (DUF4217)

RNA

  1. XR_374082.4 RNA Sequence

  2. XR_001782045.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZQ2.2 GenPept UniProtKB/Swiss-Prot:Q6NZQ2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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