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Slc2a6 solute carrier family 2 (facilitated glucose transporter), member 6 [ Mus musculus (house mouse) ]

Gene ID: 227659, updated on 11-Apr-2024

Summary

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Official Symbol
Slc2a6provided by MGI
Official Full Name
solute carrier family 2 (facilitated glucose transporter), member 6provided by MGI
Primary source
MGI:MGI:2443286
See related
Ensembl:ENSMUSG00000036067 AllianceGenome:MGI:2443286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Glut6; Glut9; GLUT-6; A330096C23; F630103L12Rik
Summary
Predicted to enable transmembrane transporter activity. Involved in regulation of glycolytic process. Predicted to be located in lysosomal membrane. Orthologous to human SLC2A6 (solute carrier family 2 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cerebellum adult (RPKM 12.1), spleen adult (RPKM 11.0) and 20 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 19.18 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26911375..26918011, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (27021363..27028000, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36649 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif 13 Neighboring gene STARR-positive B cell enhancer ABC_E7799 Neighboring gene calcium channel flower domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E5901 Neighboring gene STARR-positive B cell enhancer ABC_E7800 Neighboring gene STARR-seq mESC enhancer starr_03998 Neighboring gene ribosomal protein L6 pseudogene Neighboring gene predicted gene 13398

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity. Chen SY, et al. Int J Mol Sci, 2022 Aug 29. PMID 36077188, Free PMC Article
  2. Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice. Byrne FL, et al. Am J Physiol Endocrinol Metab, 2018 Aug 1. PMID 29664675
  3. Characterization of Glucose Transporter 6 in Lipopolysaccharide-Induced Bone Marrow-Derived Macrophage Function. Caruana BT, et al. J Immunol, 2019 Mar 15. PMID 30700586
  4. GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages. Maedera S, et al. FEBS Lett, 2019 Jan. PMID 30431159
  5. No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse. Preitner F, et al. Kidney Int, 2015 May. PMID 25565311

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity.
    Title: Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity.
  2. Study provides evidence that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.
    Title: GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates glycolysis in macrophages.
  3. these data show that GLUT6 is not a major regulator of whole body metabolic physiology
    Title: Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice.
  4. In liver-specific Glut9 knockout mice, inosine-induced hyperuricemia was not associated with hypertension despite partial renal deficiency.
    Title: No development of hypertension in the hyperuricemic liver-Glut9 knockout mouse.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (5)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of glycolytic process ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
solute carrier family 2, facilitated glucose transporter member 6
Names
glucose transporter type 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177627.1 → NP_001171098.1  solute carrier family 2, facilitated glucose transporter member 6 isoform 2

    See identical proteins and their annotated locations for NP_001171098.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region compared to variant 1. The resulting isoform (2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    BC058210, BC141168, BY202464
    Consensus CDS
    CCDS50544.1
    UniProtKB/TrEMBL
    A2AR26
    Related
    ENSMUSP00000099954.5, ENSMUST00000102890.11
    Conserved Domains (2) summary
    cd06174
    Location:41 → 415
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:40 → 434
    Sugar_tr; Sugar (and other) transporter

  2. NM_172659.2 → NP_766247.2  solute carrier family 2, facilitated glucose transporter member 6 isoform 1

    See identical proteins and their annotated locations for NP_766247.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK150104, BY202464
    Consensus CDS
    CCDS15822.1
    UniProtKB/Swiss-Prot
    A2AR26, Q3TLU5, Q3UDF0, Q8BTN2
    Related
    ENSMUSP00000049103.6, ENSMUST00000045702.6
    Conserved Domains (1) summary
    cl28910
    Location:38 → 483
    MFS; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26911375..26918011 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497917.5 → XP_006497980.1  solute carrier family 2, facilitated glucose transporter member 6 isoform X1

    Conserved Domains (1) summary
    cl28910
    Location:1 → 385
    MFS; Major Facilitator Superfamily

RNA

  1. XR_374081.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3UDF0.1 GenPept UniProtKB/Swiss-Prot:Q3UDF0

Gene LinkOut

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