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Kcnt1 potassium channel, subfamily T, member 1 [ Mus musculus (house mouse) ]

Gene ID: 227632, updated on 21-Apr-2024

Summary

Official Symbol
Kcnt1provided by MGI
Official Full Name
potassium channel, subfamily T, member 1provided by MGI
Primary source
MGI:MGI:1924627
See related
Ensembl:ENSMUSG00000058740 AllianceGenome:MGI:1924627
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
slo2; Slack; Slo2.2; C030030G16Rik
Summary
This gene encodes a member of the Slo potassium channel family that has shown to be activated by both sodium and chloride ions. This channel represents the largest potassium channel subunit yet identified. This channel may be important in development and pain signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Expression
Biased expression in cerebellum adult (RPKM 46.3), frontal lobe adult (RPKM 20.5) and 6 other tissues See more
Orthologs
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Genomic context

Location:
2 A3; 2 18.27 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25753807..25808285)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25863791..25918273)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene lipocalin 9 Neighboring gene spermatogenesis and oogenesis specific basic helix-loop-helix 1 Neighboring gene STARR-seq mESC enhancer starr_03968 Neighboring gene calmodulin regulated spectrin-associated protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1002 Neighboring gene ubiquitin associated domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3363

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • mKiaa1422

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables intracellular sodium-activated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables potassium channel activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in postsynaptic density membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density membrane IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynaptic density membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
potassium channel subfamily T member 1
Names
potassium channel subunit homolog
sodium-activated potassium channel

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145403.3NP_001138875.1  potassium channel subfamily T member 1 isoform 2

    See identical proteins and their annotated locations for NP_001138875.1

    Status: VALIDATED

    Source sequence(s)
    AL731682
    Consensus CDS
    CCDS50537.1
    UniProtKB/TrEMBL
    A0A0G2JG99, C0KTP6
    Related
    ENSMUSP00000132212.2, ENSMUST00000171268.8
    Conserved Domains (3) summary
    pfam00520
    Location:123303
    Ion_trans; Ion transport protein
    pfam03493
    Location:465559
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:239311
    Ion_trans_2; Ion channel
  2. NM_001302351.2NP_001289280.1  potassium channel subfamily T member 1 isoform 3

    See identical proteins and their annotated locations for NP_001289280.1

    Status: VALIDATED

    Source sequence(s)
    AL731682
    Consensus CDS
    CCDS79757.1
    UniProtKB/Swiss-Prot
    B2RUK3, Q6ZPR4, Q8C3E7
    UniProtKB/TrEMBL
    A0A0G2JG99
    Related
    ENSMUSP00000109809.3, ENSMUST00000114172.6
    Conserved Domains (2) summary
    pfam03493
    Location:470565
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:244317
    Ion_trans_2; Ion channel
  3. NM_175462.5NP_780671.2  potassium channel subfamily T member 1 isoform 1

    See identical proteins and their annotated locations for NP_780671.2

    Status: VALIDATED

    Source sequence(s)
    AL731682
    Consensus CDS
    CCDS15794.1
    UniProtKB/TrEMBL
    A0A0G2JG99, A2AHB8
    Related
    ENSMUSP00000039058.7, ENSMUST00000037580.13
    Conserved Domains (2) summary
    pfam03493
    Location:484579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:258331
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25753807..25808285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160711.1XP_036016604.1  potassium channel subfamily T member 1 isoform X24

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (2) summary
    pfam03493
    Location:231333
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:1284
    Ion_trans_2; Ion channel
  2. XM_036160715.1XP_036016608.1  potassium channel subfamily T member 1 isoform X26

    Conserved Domains (1) summary
    pfam03493
    Location:50152
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
  3. XM_036160708.1XP_036016601.1  potassium channel subfamily T member 1 isoform X22

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:9169
    Ion_trans; Ion transport protein
    pfam03493
    Location:323425
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:105177
    Ion_trans_2; Ion channel
  4. XM_036160716.1XP_036016609.1  potassium channel subfamily T member 1 isoform X27

    Conserved Domains (1) summary
    pfam03493
    Location:54111
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
  5. XM_006497892.5XP_006497955.1  potassium channel subfamily T member 1 isoform X23

    UniProtKB/TrEMBL
    A0A0G2JER3, A0A0G2JG99
    Related
    ENSMUSP00000142870.2, ENSMUST00000198204.5
    Conserved Domains (3) summary
    pfam00520
    Location:123289
    Ion_trans; Ion transport protein
    pfam03493
    Location:450545
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:225291
    Ion_trans_2; Ion channel
  6. XM_006497891.5XP_006497954.1  potassium channel subfamily T member 1 isoform X18

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:123289
    Ion_trans; Ion transport protein
    pfam03493
    Location:451546
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:225291
    Ion_trans_2; Ion channel
  7. XM_030249674.2XP_030105534.1  potassium channel subfamily T member 1 isoform X19

    UniProtKB/TrEMBL
    A0A0G2JG99
    Related
    ENSMUSP00000143482.2, ENSMUST00000200434.5
    Conserved Domains (3) summary
    pfam00520
    Location:123289
    Ion_trans; Ion transport protein
    pfam03493
    Location:450545
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:225291
    Ion_trans_2; Ion channel
  8. XM_030249691.1XP_030105551.1  potassium channel subfamily T member 1 isoform X26

    Conserved Domains (1) summary
    pfam03493
    Location:50152
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
  9. XM_036160720.1XP_036016613.1  potassium channel subfamily T member 1 isoform X31

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:63270
    Ion_trans; Ion transport protein
    pfam03493
    Location:424526
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:206278
    Ion_trans_2; Ion channel
  10. XM_006497895.5XP_006497958.2  potassium channel subfamily T member 1 isoform X25

    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:485580
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  11. XM_030249677.2XP_030105537.1  potassium channel subfamily T member 1 isoform X21

    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:485580
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  12. XM_006497883.5XP_006497946.2  potassium channel subfamily T member 1 isoform X10

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:485580
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  13. XM_006497884.5XP_006497947.2  potassium channel subfamily T member 1 isoform X11

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:485580
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  14. XM_017317198.3XP_017172687.1  potassium channel subfamily T member 1 isoform X16

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (2) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  15. XM_017317195.3XP_017172684.1  potassium channel subfamily T member 1 isoform X12

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:484579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  16. XM_006497889.5XP_006497952.2  potassium channel subfamily T member 1 isoform X20

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (2) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  17. XM_017317197.2XP_017172686.1  potassium channel subfamily T member 1 isoform X15

    UniProtKB/TrEMBL
    A0A0G2JG99, A2AHB7
    Related
    ENSMUSP00000109813.3, ENSMUST00000114176.9
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:484579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  18. XM_006497886.4XP_006497949.2  potassium channel subfamily T member 1 isoform X13

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    PRK10537
    Location:158288
    PRK10537; voltage-gated potassium channel protein
    pfam03493
    Location:457552
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:231297
    Ion_trans_2; Ion channel
  19. XM_006497877.4XP_006497940.2  potassium channel subfamily T member 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:485580
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  20. XM_006497879.5XP_006497942.2  potassium channel subfamily T member 1 isoform X3

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:485580
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  21. XM_036160686.1XP_036016579.1  potassium channel subfamily T member 1 isoform X4

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:143323
    Ion_trans; Ion transport protein
    pfam03493
    Location:477579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259331
    Ion_trans_2; Ion channel
  22. XM_036160690.1XP_036016583.1  potassium channel subfamily T member 1 isoform X14

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    PRK10537
    Location:158288
    PRK10537; voltage-gated potassium channel protein
    pfam03493
    Location:449551
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:231303
    Ion_trans_2; Ion channel
  23. XM_030249663.2XP_030105523.1  potassium channel subfamily T member 1 isoform X17

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (2) summary
    pfam00520
    Location:143309
    Ion_trans; Ion transport protein
    pfam07885
    Location:245311
    Ion_trans_2; Ion channel
  24. XM_006497880.4XP_006497943.2  potassium channel subfamily T member 1 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:485580
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  25. XM_006497878.4XP_006497941.2  potassium channel subfamily T member 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:484579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  26. XM_006497881.4XP_006497944.2  potassium channel subfamily T member 1 isoform X6

    UniProtKB/TrEMBL
    A0A0G2JG99, A2AHB9
    Related
    ENSMUSP00000143106.2, ENSMUST00000197917.5
    Conserved Domains (3) summary
    pfam00520
    Location:157323
    Ion_trans; Ion transport protein
    pfam03493
    Location:484579
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:259325
    Ion_trans_2; Ion channel
  27. XM_006497882.5XP_006497945.2  potassium channel subfamily T member 1 isoform X7

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:143309
    Ion_trans; Ion transport protein
    pfam03493
    Location:471566
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:245311
    Ion_trans_2; Ion channel
  28. XM_030249645.1XP_030105505.1  potassium channel subfamily T member 1 isoform X8

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:143309
    Ion_trans; Ion transport protein
    pfam03493
    Location:470565
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:245311
    Ion_trans_2; Ion channel
  29. XM_030249649.1XP_030105509.1  potassium channel subfamily T member 1 isoform X9

    UniProtKB/TrEMBL
    A0A0G2JG99
    Conserved Domains (3) summary
    pfam00520
    Location:143309
    Ion_trans; Ion transport protein
    pfam03493
    Location:470565
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
    pfam07885
    Location:245311
    Ion_trans_2; Ion channel
  30. XM_036160719.1XP_036016612.1  potassium channel subfamily T member 1 isoform X29

    Conserved Domains (1) summary
    pfam03493
    Location:183
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
  31. XM_006497896.4XP_006497959.1  potassium channel subfamily T member 1 isoform X27

    Conserved Domains (1) summary
    pfam03493
    Location:54111
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
  32. XM_030249700.1XP_030105560.1  potassium channel subfamily T member 1 isoform X28

    Conserved Domains (1) summary
    pfam03493
    Location:54111
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
  33. XM_036160718.1XP_036016611.1  potassium channel subfamily T member 1 isoform X27

    Conserved Domains (1) summary
    pfam03493
    Location:54111
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit
  34. XM_017317210.2XP_017172699.1  potassium channel subfamily T member 1 isoform X30

    Conserved Domains (1) summary
    cl29357
    Location:933
    BK_channel_a; Calcium-activated BK potassium channel alpha subunit

RNA

  1. XR_004939568.1 RNA Sequence

  2. XR_003952108.2 RNA Sequence

  3. XR_004939562.1 RNA Sequence

  4. XR_004939563.1 RNA Sequence