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Rpp38 ribonuclease P/MRP 38 subunit [ Mus musculus (house mouse) ]

Gene ID: 227522, updated on 5-Mar-2024

Summary

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Official Symbol
Rpp38provided by MGI
Official Full Name
ribonuclease P/MRP 38 subunitprovided by MGI
Primary source
MGI:MGI:2443607
See related
Ensembl:ENSMUSG00000049950 AllianceGenome:MGI:2443607
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C330006A15Rik
Summary
Predicted to enable ribonuclease P RNA binding activity. Predicted to contribute to ribonuclease P activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to act upstream of or within rRNA processing and tRNA processing. Predicted to be located in nucleolus. Predicted to be part of multimeric ribonuclease P complex. Predicted to be active in fibrillar center. Orthologous to human RPP38 (ribonuclease P/MRP subunit p38). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in frontal lobe adult (RPKM 12.8), CNS E18 (RPKM 9.7) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A1; 2 1.87 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (3328305..3334023, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (3326548..3332986, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 171, member A1 Neighboring gene predicted gene, 54098 Neighboring gene STARR-seq mESC enhancer starr_03511 Neighboring gene predicted gene, 22005 Neighboring gene N-myristoyltransferase 2 Neighboring gene STARR-positive B cell enhancer ABC_E999 Neighboring gene acyl-Coenzyme A binding domain containing 7 Neighboring gene oleoyl-ACP hydrolase Neighboring gene STARR-seq mESC enhancer starr_03512 Neighboring gene predicted gene, 39750

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Eukaryotic ribonuclease P: a plurality of ribonucleoprotein enzymes. Xiao S, et al. Annu Rev Biochem, 2002. PMID 12045094, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ribonuclease P RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribonuclease P RNA binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to ribonuclease P activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to ribonuclease P activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within rRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA 5'-leader removal IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA 5'-leader removal ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in fibrillar center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
part_of multimeric ribonuclease P complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of multimeric ribonuclease P complex ISO
Inferred from Sequence Orthology
more info
  
part_of nucleolar ribonuclease P complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonuclease MRP complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ribonuclease P protein subunit p38
Names
RNaseP protein p38
ribonuclease P/MRP 38kDa subunit
NP_001013394.2
XP_006497513.1
XP_006497514.1
XP_030105367.1
XP_030105369.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013376.2 → NP_001013394.2  ribonuclease P protein subunit p38

    See identical proteins and their annotated locations for NP_001013394.2

    Status: VALIDATED

    Source sequence(s)
    AL732620
    Consensus CDS
    CCDS15645.1
    UniProtKB/Swiss-Prot
    Q3UTW5, Q80UU2, Q8BU46
    UniProtKB/TrEMBL
    A2AJG0
    Related
    ENSMUSP00000050992.7, ENSMUST00000062672.7
    Conserved Domains (1) summary
    pfam01248
    Location:102 → 180
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    3328305..3334023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497450.5 → XP_006497513.1  ribonuclease P protein subunit p38 isoform X2

    See identical proteins and their annotated locations for XP_006497513.1

    UniProtKB/Swiss-Prot
    Q3UTW5, Q80UU2, Q8BU46
    UniProtKB/TrEMBL
    A2AJG0
    Conserved Domains (1) summary
    pfam01248
    Location:102 → 180
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

  2. XM_030249509.2 → XP_030105369.1  ribonuclease P protein subunit p38 isoform X2

    UniProtKB/Swiss-Prot
    Q3UTW5, Q80UU2, Q8BU46
    UniProtKB/TrEMBL
    A2AJG0
    Conserved Domains (1) summary
    pfam01248
    Location:102 → 180
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

  3. XM_030249507.2 → XP_030105367.1  ribonuclease P protein subunit p38 isoform X1

    UniProtKB/Swiss-Prot
    Q3UTW5, Q80UU2, Q8BU46
    Conserved Domains (1) summary
    pfam01248
    Location:172 → 250
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family

  4. XM_006497451.5 → XP_006497514.1  ribonuclease P protein subunit p38 isoform X2

    See identical proteins and their annotated locations for XP_006497514.1

    UniProtKB/Swiss-Prot
    Q3UTW5, Q80UU2, Q8BU46
    UniProtKB/TrEMBL
    A2AJG0
    Conserved Domains (1) summary
    pfam01248
    Location:102 → 180
    Ribosomal_L7Ae; Ribosomal protein L7Ae/L30e/S12e/Gadd45 family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80UU2.1 GenPept UniProtKB/Swiss-Prot:Q80UU2

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