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Zfp90 zinc finger protein 90 [ Mus musculus (house mouse) ]

Gene ID: 22751, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp90provided by MGI
Official Full Name
zinc finger protein 90provided by MGI
Primary source
MGI:MGI:104786
See related
Ensembl:ENSMUSG00000031907 AllianceGenome:MGI:104786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NK10; Zfp64; Zfp83; KRAB17; mKIAA1954; 6430515L01Rik
Summary
Enables DNA binding activity and DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in negative regulation of DNA binding activity; negative regulation of transcription, DNA-templated; and positive regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including heart; hemolymphoid system gland; lung; male reproductive system; and urinary system. Orthologous to human ZFP90 (ZFP90 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 6.3), CNS E14 (RPKM 6.0) and 23 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp90 in Genome Data Viewer
Location:
8 D3; 8 53.14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107141929..107153575)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106415295..106426943)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39238 Neighboring gene STARR-positive B cell enhancer mm9_chr8:108935799-108936099 Neighboring gene predicted gene, 34026 Neighboring gene STARR-positive B cell enhancer ABC_E3802 Neighboring gene STARR-seq mESC enhancer starr_22555 Neighboring gene predicted gene, 51545 Neighboring gene STARR-seq mESC enhancer starr_22556 Neighboring gene STARR-seq mESC enhancer starr_22558 Neighboring gene STARR-seq mESC enhancer starr_22559 Neighboring gene cadherin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells. Liu T, et al. Cell Death Dis, 2018 Jun 7. PMID 29880802, Free PMC Article
  2. A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90. Yu CY, et al. Oncogene, 2020 Feb. PMID 31641208, Free PMC Article
  3. Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes. Hata L, et al. J Mol Cell Cardiol, 2011 Jun. PMID 21284946
  4. Developmentally regulated mouse gene NK10 encodes a zinc finger repressor protein with differential DNA-binding domains. Lange R, et al. DNA Cell Biol, 1995 Nov. PMID 7576184
  5. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Zfp90 was highly expressed in hematopoietic stem cells.
    Title: The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells.
  2. Zfp90 functions as a negative regulator of NRSF and contributes to genetic remodeling during the development of cardiac dysfunction.
    Title: Zinc-finger protein 90 negatively regulates neuron-restrictive silencer factor-mediated transcriptional repression of fetal cardiac genes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 90
Names
Nk10 expressed protein
zfp-90
zinc finger protein 83
zinc finger protein 90 homolog
zinc finger protein NK10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368328.1 → NP_001355257.1  zinc finger protein 90 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096

  2. NM_001368329.1 → NP_001355258.1  zinc finger protein 90 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096
    Conserved Domains (2) summary
    COG5048
    Location:189 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:516 → 536
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001368330.1 → NP_001355259.1  zinc finger protein 90 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096

  4. NM_001368331.1 → NP_001355260.1  zinc finger protein 90 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096

  5. NM_011764.4 → NP_035894.1  zinc finger protein 90 isoform 2

    See identical proteins and their annotated locations for NP_035894.1

    Status: VALIDATED

    Source sequence(s)
    AC134615, AC164096
    Consensus CDS
    CCDS22635.1
    UniProtKB/Swiss-Prot
    Q3U4J5, Q543I6, Q61967
    Related
    ENSMUSP00000034382.8, ENSMUST00000034382.8
    Conserved Domains (5) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:197 → 625
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:524 → 544
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:536 → 561
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107141929..107153575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006530849.5 → XP_006530912.1  zinc finger protein 90 isoform X1

    See identical proteins and their annotated locations for XP_006530912.1

    Related
    ENSMUST00000211958.2
    Conserved Domains (2) summary
    COG5048
    Location:189 → 617
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:516 → 536
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61967.1 GenPept UniProtKB/Swiss-Prot:Q61967

Gene LinkOut

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