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Zcchc2 zinc finger, CCHC domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 227449, updated on 5-Mar-2024

Summary

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Official Symbol
Zcchc2provided by MGI
Official Full Name
zinc finger, CCHC domain containing 2provided by MGI
Primary source
MGI:MGI:2444114
See related
Ensembl:ENSMUSG00000038866 AllianceGenome:MGI:2444114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9930114B20Rik
Summary
Predicted to enable nucleic acid binding activity; phosphatidylinositol binding activity; and zinc ion binding activity. Predicted to be located in cytoplasm. Is expressed in metanephros; submandibular gland primordium; and thymus primordium. Orthologous to human ZCCHC2 (zinc finger CCHC-type containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 19.4), thymus adult (RPKM 8.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E2.1; 1 49.76 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (105916929..105961807)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (105990390..106034077)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26214 Neighboring gene zinc finger protein of the cerebellum 5 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E795 Neighboring gene STARR-positive B cell enhancer ABC_E8772 Neighboring gene STARR-positive B cell enhancer ABC_E5787 Neighboring gene predicted gene 7160 Neighboring gene STARR-seq mESC enhancer starr_01847 Neighboring gene STARR-positive B cell enhancer ABC_E4340 Neighboring gene STARR-positive B cell enhancer ABC_E2556 Neighboring gene STARR-seq mESC enhancer starr_01848 Neighboring gene predicted gene, 26509 Neighboring gene STARR-seq mESC enhancer starr_01850 Neighboring gene STARR-positive B cell enhancer ABC_E9059 Neighboring gene STARR-positive B cell enhancer ABC_E2005 Neighboring gene predicted gene, 20753

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  2. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article
  3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
  4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger CCHC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122675.1 → NP_001116147.1  zinc finger CCHC domain-containing protein 2 isoform B

    Status: VALIDATED

    Source sequence(s)
    AK046562, AK173248, BP762779
    Consensus CDS
    CCDS48336.1
    UniProtKB/Swiss-Prot
    Q69ZB8
    Related
    ENSMUSP00000113128.2, ENSMUST00000119166.8
    Conserved Domains (2) summary
    pfam00098
    Location:1121 → 1136
    zf-CCHC; Zinc knuckle
    cl02563
    Location:341 → 433
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. NM_001122676.1 → NP_001116148.1  zinc finger CCHC domain-containing protein 2 isoform A

    See identical proteins and their annotated locations for NP_001116148.1

    Status: VALIDATED

    Source sequence(s)
    AK046562, AK173248, BC055760, BP762779
    Consensus CDS
    CCDS48335.1
    UniProtKB/Swiss-Prot
    Q69ZB8, Q7TNF1, Q8CB08
    Related
    ENSMUSP00000113974.2, ENSMUST00000118196.8
    Conserved Domains (2) summary
    pfam00098
    Location:1121 → 1136
    zf-CCHC; Zinc knuckle
    cl02563
    Location:341 → 433
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    105916929..105961807
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529512.5 → XP_006529575.1  zinc finger CCHC domain-containing protein 2 isoform X1

    Conserved Domains (4) summary
    PHA03247
    Location:813 → 960
    PHA03247; large tegument protein UL36; Provisional
    pfam00098
    Location:1126 → 1141
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:657 → 944
    DUF5585; Family of unknown function (DUF5585)
    cl02563
    Location:341 → 433
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  2. XM_006529516.5 → XP_006529579.1  zinc finger CCHC domain-containing protein 2 isoform X6

    Conserved Domains (4) summary
    PHA03379
    Location:739 → 1066
    PHA03379; EBNA-3A; Provisional
    pfam00098
    Location:1078 → 1093
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:587 → 896
    DUF5585; Family of unknown function (DUF5585)
    cl02563
    Location:341 → 433
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  3. XM_006529514.5 → XP_006529577.1  zinc finger CCHC domain-containing protein 2 isoform X3

    Conserved Domains (4) summary
    PHA03247
    Location:785 → 932
    PHA03247; large tegument protein UL36; Provisional
    pfam00098
    Location:1098 → 1113
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:629 → 916
    DUF5585; Family of unknown function (DUF5585)
    cl02563
    Location:341 → 433
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  4. XM_006529515.5 → XP_006529578.1  zinc finger CCHC domain-containing protein 2 isoform X5

    Conserved Domains (4) summary
    PHA03247
    Location:780 → 927
    PHA03247; large tegument protein UL36; Provisional
    pfam00098
    Location:1093 → 1108
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:624 → 911
    DUF5585; Family of unknown function (DUF5585)
    cl02563
    Location:341 → 433
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  5. XM_030253840.2 → XP_030109700.1  zinc finger CCHC domain-containing protein 2 isoform X9

    Conserved Domains (4) summary
    PHA03379
    Location:711 → 1038
    PHA03379; EBNA-3A; Provisional
    pfam00098
    Location:1050 → 1065
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:559 → 868
    DUF5585; Family of unknown function (DUF5585)
    cl02563
    Location:341 → 433
    PX_domain; The Phox Homology domain, a phosphoinositide binding module

  6. XM_006529513.5 → XP_006529576.1  zinc finger CCHC domain-containing protein 2 isoform X2

    Conserved Domains (3) summary
    PHA03247
    Location:789 → 936
    PHA03247; large tegument protein UL36; Provisional
    pfam00098
    Location:1102 → 1117
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:633 → 920
    DUF5585; Family of unknown function (DUF5585)

  7. XM_030253835.2 → XP_030109695.1  zinc finger CCHC domain-containing protein 2 isoform X4

    Conserved Domains (3) summary
    PHA03247
    Location:784 → 931
    PHA03247; large tegument protein UL36; Provisional
    pfam00098
    Location:1097 → 1112
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:628 → 915
    DUF5585; Family of unknown function (DUF5585)

  8. XM_006529517.5 → XP_006529580.1  zinc finger CCHC domain-containing protein 2 isoform X7

    Conserved Domains (3) summary
    PHA03247
    Location:761 → 908
    PHA03247; large tegument protein UL36; Provisional
    pfam00098
    Location:1074 → 1089
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:605 → 892
    DUF5585; Family of unknown function (DUF5585)

  9. XM_006529518.5 → XP_006529581.1  zinc finger CCHC domain-containing protein 2 isoform X8

    Conserved Domains (3) summary
    PHA03247
    Location:756 → 903
    PHA03247; large tegument protein UL36; Provisional
    pfam00098
    Location:1069 → 1084
    zf-CCHC; Zinc knuckle
    pfam17823
    Location:600 → 887
    DUF5585; Family of unknown function (DUF5585)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q69ZB8.3 GenPept UniProtKB/Swiss-Prot:Q69ZB8

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