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Slco4c1 solute carrier organic anion transporter family, member 4C1 [ Mus musculus (house mouse) ]

Gene ID: 227394, updated on 5-Mar-2024

Summary

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Official Symbol
Slco4c1provided by MGI
Official Full Name
solute carrier organic anion transporter family, member 4C1provided by MGI
Primary source
MGI:MGI:2442784
See related
Ensembl:ENSMUSG00000040693 AllianceGenome:MGI:2442784
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OATPX; OATP-H; oatp-R; OATP-M1; OATP4C1; PRO2176; SLC21A20; 9530051F04; C330017E21Rik
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Predicted to act upstream of or within cell differentiation; ion transport; and spermatogenesis. Predicted to be located in basolateral plasma membrane. Predicted to be integral component of membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including forebrain; genitourinary system; integumental system; respiratory system; and sensory organ. Orthologous to human SLCO4C1 (solute carrier organic anion transporter family member 4C1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in genital fat pad adult (RPKM 3.6), lung adult (RPKM 3.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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See Slco4c1 in Genome Data Viewer
Location:
1 D; 1 47.76 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (96744918..96800027, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (96816270..96872193, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930533P14 gene Neighboring gene abhydrolase domain containing 6 pseudogene Neighboring gene STARR-seq mESC enhancer starr_01769 Neighboring gene predicted gene, 26078 Neighboring gene STARR-seq mESC enhancer starr_01771 Neighboring gene STARR-seq mESC enhancer starr_01772 Neighboring gene pluripotency-associated noncoding transcript 2 Neighboring gene solute carrier organic anion transporter family, member 6b1 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental and cell type-specific expression of thyroid hormone transporters in the mouse brain and in primary brain cells. Braun D, et al. Glia, 2011 Mar. PMID 21264952
  2. Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys. Cheng X, et al. Drug Metab Dispos, 2009 Nov. PMID 19679677, Free PMC Article
  3. FGFR2b signalling restricts lineage-flexible alveolar progenitors during mouse lung development and converges in mature alveolar type 2 cells. Jones MR, et al. Cell Mol Life Sci, 2022 Nov 29. PMID 36445537, Free PMC Article
  4. Neuronal 3',3,5-triiodothyronine (T3) uptake and behavioral phenotype of mice deficient in Mct8, the neuronal T3 transporter mutated in Allan-Herndon-Dudley syndrome. Wirth EK, et al. J Neurosci, 2009 Jul 29. PMID 19641107, Free PMC Article
  5. USP10 deubiquitinates Tau, mediating its aggregation. Wei Z, et al. Cell Death Dis, 2022 Aug 20. PMID 35987808, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables organic anion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in organic anion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier organic anion transporter family member 4C1
Names
organic anion transporting polypeptide 4C1
solute carrier family 21 member 20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172658.3 → NP_766246.1  solute carrier organic anion transporter family member 4C1

    See identical proteins and their annotated locations for NP_766246.1

    Status: PROVISIONAL

    Source sequence(s)
    AK049253
    Consensus CDS
    CCDS35675.1
    UniProtKB/Swiss-Prot
    Q8BGD4
    Related
    ENSMUSP00000071875.5, ENSMUST00000071985.6
    Conserved Domains (3) summary
    cd06174
    Location:120 → 473
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:496 → 549
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:102 → 662
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    96744918..96800027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001784188.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BGD4.1 GenPept UniProtKB/Swiss-Prot:Q8BGD4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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