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Aamp angio-associated migratory protein [ Mus musculus (house mouse) ]

Gene ID: 227290, updated on 5-Mar-2024

Summary

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Official Symbol
Aampprovided by MGI
Official Full Name
angio-associated migratory proteinprovided by MGI
Primary source
MGI:MGI:107809
See related
Ensembl:ENSMUSG00000006299 AllianceGenome:MGI:107809
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Aamp-rs
Summary
Predicted to enable heparin binding activity. Predicted to be located in cell surface; intercellular bridge; and microtubule cytoskeleton. Predicted to be active in cytosol. Orthologous to human AAMP (angio associated migratory cell protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 243.7), placenta adult (RPKM 83.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C3; 1 38.53 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74318999..74324833, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74279840..74284738, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1996 Neighboring gene actin related protein 2/3 complex, subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E175 Neighboring gene G protein-coupled bile acid receptor 1 Neighboring gene predicted gene 28364 Neighboring gene paroxysmal nonkinesiogenic dyskinesia Neighboring gene transmembrane BAX inhibitor motif containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3281 Neighboring gene STARR-positive B cell enhancer ABC_E4323 Neighboring gene STARR-seq mESC enhancer starr_01333 Neighboring gene ciliogenesis associated TTC17 interacting protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A high-resolution genetic, physical, and comparative gene map of the doublefoot (Dbf) region of mouse chromosome 1 and the region of conserved synteny on human chromosome 2q35. Hayes C, et al. Genomics, 2001 Dec. PMID 11735226
  2. Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta. Ramamoorthy S, et al. Biochem J, 1994 Jun 15. PMID 8010975, Free PMC Article
  3. High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population. Mugford JW, et al. Dev Biol, 2009 Sep 15. PMID 19591821, Free PMC Article
  4. Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Brady KP, et al. Genome Res, 1997 Nov. PMID 9371744, Free PMC Article
  5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC30660

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparin binding ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
angio-associated migratory cell protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190444.1 → NP_001177373.1  angio-associated migratory cell protein isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC113473
    Consensus CDS
    CCDS56631.1
    UniProtKB/TrEMBL
    J3QN89, Q3U9F0
    Related
    ENSMUSP00000136644.2, ENSMUST00000178235.8
    Conserved Domains (4) summary
    smart00320
    Location:391 → 429
    WD40; WD40 repeats
    COG2319
    Location:91 → 432
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:88 → 388
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:139 → 177
    7WD40; WD40 repeat [structural motif]

  2. NM_146110.3 → NP_666222.2  angio-associated migratory cell protein isoform 2

    See identical proteins and their annotated locations for NP_666222.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AK162750, AV170929, BY101182
    Consensus CDS
    CCDS15043.1
    UniProtKB/TrEMBL
    Q3TJ22, Q3U9F0
    Related
    ENSMUSP00000006462.8, ENSMUST00000006462.14
    Conserved Domains (3) summary
    smart00320
    Location:390 → 428
    WD40; WD40 repeats
    cd00200
    Location:87 → 387
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:138 → 176
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    74318999..74324833 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164458.1 → XP_036020351.1  angio-associated migratory cell protein isoform X1

    UniProtKB/TrEMBL
    Q3TJ22, Q3U9F0
    Conserved Domains (3) summary
    smart00320
    Location:390 → 428
    WD40; WD40 repeats
    cd00200
    Location:87 → 387
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:138 → 176
    7WD40; WD40 repeat [structural motif]

  2. XM_006495958.5 → XP_006496021.1  angio-associated migratory cell protein isoform X3

    UniProtKB/TrEMBL
    Q3U9F0
    Conserved Domains (3) summary
    smart00320
    Location:384 → 422
    WD40; WD40 repeats
    cd00200
    Location:81 → 381
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:132 → 170
    7WD40; WD40 repeat [structural motif]

  3. XM_006495957.5 → XP_006496020.1  angio-associated migratory cell protein isoform X2

    UniProtKB/TrEMBL
    Q3U9F0
    Conserved Domains (3) summary
    smart00320
    Location:385 → 423
    WD40; WD40 repeats
    cd00200
    Location:82 → 382
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:133 → 171
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein Strain
Heading Accession and Version

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