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Zfp64 zinc finger protein 64 [ Mus musculus (house mouse) ]

Gene ID: 22722, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp64provided by MGI
Official Full Name
zinc finger protein 64provided by MGI
Primary source
MGI:MGI:107342
See related
Ensembl:ENSMUSG00000027551 AllianceGenome:MGI:107342
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm38422
Summary
Predicted to enable DNA binding activity and metal ion binding activity. Involved in positive regulation of interferon-beta production; positive regulation of interleukin-6 production; and positive regulation of tumor necrosis factor production. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; embryo mesenchyme; genitourinary system; gut; and hemolymphoid system gland. Orthologous to human ZFP64 (ZFP64 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 17.9), ovary adult (RPKM 14.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 H3; 2 88.99 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (168735251..168797507, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (168893331..168955587, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06472 Neighboring gene spalt like transcription factor 4 Neighboring gene predicted gene 14261 Neighboring gene predicted gene, 25214 Neighboring gene STARR-positive B cell enhancer ABC_E3422 Neighboring gene STARR-positive B cell enhancer ABC_E6025 Neighboring gene STARR-seq mESC enhancer starr_06482 Neighboring gene RIKEN cDNA 1700017J07 gene Neighboring gene predicted gene, 39993

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfp64 participates in Notch signaling and regulates differentiation in mesenchymal cells. Sakamoto K, et al. J Cell Sci, 2008 May 15. PMID 18430783
  2. A search for a mammalian homologue of the Drosophila photoreceptor development gene glass yields Zfp64, a zinc finger encoding gene which maps to the distal end of mouse chromosome 2. Mack HG, et al. Gene, 1997 Jan 31. PMID 9034307
  3. Genomic structure, chromosomal mapping, and muscle-specific expression of a PH domain-associated intronless gene, cded/lior. Mishra L, et al. Mamm Genome, 1999 Jan. PMID 9892736
  4. Identification of Stk6/STK15 as a candidate low-penetrance tumor-susceptibility gene in mouse and human. Ewart-Toland A, et al. Nat Genet, 2003 Aug. PMID 12881723
  5. Identification of tooth-specific downstream targets of Runx2. Gaikwad JS, et al. Gene, 2001 Nov 14. PMID 11722849

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mesenchymal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 64
Names
zfp-64

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369059.1 → NP_001355988.1  zinc finger protein 64 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL844882
    Consensus CDS
    CCDS89588.1
    UniProtKB/Swiss-Prot
    P97365, Q99KE8, Q9CWR3
    UniProtKB/TrEMBL
    A2AQR3
    Related
    ENSMUSP00000104790.3, ENSMUST00000109162.9
    Conserved Domains (2) summary
    COG5048
    Location:170 → 553
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001370946.1 → NP_001357875.1  zinc finger protein 64 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL844882
    Conserved Domains (3) summary
    COG5048
    Location:95 → 226
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:113 → 133
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:97 → 122
    zf-H2C2_2; Zinc-finger double domain

  3. NM_009564.2 → NP_033590.2  zinc finger protein 64 isoform 1

    See identical proteins and their annotated locations for NP_033590.2

    Status: VALIDATED

    Source sequence(s)
    AK146036, BY752610, CX734245
    Consensus CDS
    CCDS50804.1
    UniProtKB/TrEMBL
    A2AQR4
    Related
    ENSMUSP00000085285.5, ENSMUST00000087971.11
    Conserved Domains (4) summary
    COG5048
    Location:149 → 448
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:175 → 195
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:159 → 184
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:422 → 448
    zf-C2H2_6; C2H2-type zinc finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    168735251..168797507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99KE8.1 GenPept UniProtKB/Swiss-Prot:Q99KE8

Gene LinkOut

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