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Ccnyl1 cyclin Y-like 1 [ Mus musculus (house mouse) ]

Gene ID: 227210, updated on 13-Apr-2024

Summary

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Official Symbol
Ccnyl1provided by MGI
Official Full Name
cyclin Y-like 1provided by MGI
Primary source
MGI:MGI:2138614
See related
Ensembl:ENSMUSG00000070871 AllianceGenome:MGI:2138614
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630037P07Rik
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase activator activity. Acts upstream of or within flagellated sperm motility; regulation of protein kinase activity; and spermatogenesis. Located in plasma membrane. Is expressed in several structures, including genitourinary system; gut; liver; mammary gland; and spleen. Orthologous to human CCNYL1 (cyclin Y like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 21.2), limb E14.5 (RPKM 6.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Ccnyl1 in Genome Data Viewer
Location:
1 C2; 1 32.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (64729963..64764805)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (64691041..64725646)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 29152 Neighboring gene RIKEN cDNA 2810408I11 gene Neighboring gene STARR-positive B cell enhancer ABC_E983 Neighboring gene STARR-positive B cell enhancer ABC_E9466 Neighboring gene STARR-positive B cell enhancer ABC_E11072 Neighboring gene STARR-seq mESC enhancer starr_01166 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:64784525-64784634 Neighboring gene frizzled class receptor 5 Neighboring gene pleckstrin homology domain containing, family M, member 3 Neighboring gene leucine rich repeat containing 15 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Post-transcriptional Wnt Signaling Governs Epididymal Sperm Maturation. Koch S, et al. Cell, 2015 Nov 19. PMID 26590424
  2. CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse. Zi Z, et al. PLoS Genet, 2015 Aug. PMID 26305884, Free PMC Article
  3. Essential Roles of Cyclin Y-Like 1 and Cyclin Y in Dividing Wnt-Responsive Mammary Stem/Progenitor Cells. Zeng L, et al. PLoS Genet, 2016 May. PMID 27203244, Free PMC Article
  4. Primary cilia are WNT-transducing organelles whose biogenesis is controlled by a WNT-PP1 axis. Zhang K, et al. Dev Cell, 2023 Jan 23. PMID 36693320
  5. Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. Da Silva F, et al. EMBO J, 2021 Oct 1. PMID 34431536, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within flagellated sperm motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclin-Y-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097644.1 → NP_001091113.1  cyclin-Y-like protein 1

    See identical proteins and their annotated locations for NP_001091113.1

    Status: VALIDATED

    Source sequence(s)
    AK079350, AK132782, BE944301, CN668580, DV657169
    Consensus CDS
    CCDS48281.1
    Related
    ENSMUSP00000092499.4, ENSMUST00000094898.5
    Conserved Domains (1) summary
    pfam00134
    Location:124 → 215
    Cyclin_N; Cyclin, N-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    64729963..64764805
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006495953.4 → XP_006496016.1  cyclin-Y-like protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006496016.1

    UniProtKB/Swiss-Prot
    D3YUJ3, E9Q226
    Conserved Domains (1) summary
    cd20540
    Location:138 → 234
    CYCLIN_CCNY_like; cyclin box found in cyclin-Y (CCNY) family

  2. XM_011238499.3 → XP_011236801.1  cyclin-Y-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    D3YUJ3, E9Q226
    Related
    ENSMUSP00000109711.2, ENSMUST00000114077.8
    Conserved Domains (1) summary
    pfam00134
    Location:197 → 288
    Cyclin_N; Cyclin, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3YUJ3.1 GenPept UniProtKB/Swiss-Prot:D3YUJ3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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