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Mpp4 membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4) [ Mus musculus (house mouse) ]

Gene ID: 227157, updated on 21-Apr-2024

Summary

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Official Symbol
Mpp4provided by MGI
Official Full Name
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)provided by MGI
Primary source
MGI:MGI:2386681
See related
Ensembl:ENSMUSG00000079550 AllianceGenome:MGI:2386681
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dlg6
Summary
Predicted to enable signaling receptor binding activity. Acts upstream of or within protein localization to synapse. Located in several cellular components, including cone cell pedicle; lateral plasma membrane; and rod spherule. Is expressed in several structures, including cerebellum and neural retina. Orthologous to human MPP4 (MAGUK p55 scaffold protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 7.2), liver adult (RPKM 3.2) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 C1.3; 1 29.2 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59160094..59202548, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (59120935..59163389, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene predicted gene, 25502 Neighboring gene transmembrane protein 237 Neighboring gene STARR-seq mESC enhancer starr_01030 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59219938-59220121 Neighboring gene predicted gene, 19125 Neighboring gene alsin Rho guanine nucleotide exchange factor Neighboring gene STARR-positive B cell enhancer ABC_E1993 Neighboring gene predicted gene, 33667 Neighboring gene STARR-seq mESC enhancer starr_01032 Neighboring gene cyclin dependent kinase 15 Neighboring gene VISTA enhancer mm1575 Neighboring gene VISTA enhancer mm489 Neighboring gene predicted gene, 51625

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Yang J, et al. Hum Mol Genet, 2007 May 1. PMID 17341488
  2. Cellular localization of the MPP4 protein in the mammalian retina. Stöhr H, et al. Invest Ophthalmol Vis Sci, 2003 Dec. PMID 14638699
  3. Developmental and tissue expression patterns of mouse Mpp4 gene. Li M, et al. Biochem Biophys Res Commun, 2003 Jul 25. PMID 12859944
  4. Spatial distribution of mDLG6 mRNA in embryonic and adult mouse brain. Inagaki H, et al. Cell Biol Int, 2002. PMID 12127943
  5. Characterization of MPP4, a gene highly expressed in photoreceptor cells, and mutation analysis in retinitis pigmentosa. Conte I, et al. Gene, 2002 Sep 4. PMID 12384283

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that both scaffold proteins PSD95beta and MPP4 are essential for the modulation of PMCA levels at the presynaptic plasma membrane and thereby influence the photoreceptor synaptic calcium handling.
    Title: PSD95beta regulates plasma membrane Ca2+ pump localization at the photoreceptor synapse.
  2. These findings suggest that Mpp4 coordinates Psd95/Veli3 assembly and maintenance at synaptic membranes. Mpp4 is a critical recruitment factor to organize scaffolds at the photoreceptor synapse.
    Title: Mpp4 recruits Psd95 and Veli3 towards the photoreceptor synapse.
  3. Results show that Mpp4 organizes a presynaptic protein complex and has a role in modulating Ca(2+) homeostasis and synaptic transmission in rod photoreceptors.
    Title: Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals.
  4. Results describe the temporal and spatial expression patterns of mouse membrane palmitoylated protein 4 (Mpp4) gene.
    Title: Developmental and tissue expression patterns of mouse Mpp4 gene.
  5. Association of Veli3 with MPP4 suggests that the MAGUKs recruit Veli3 and its binding partners to different cellular regions of the retina where they may participate in the organization of specialized intercellular junctions.
    Title: Membrane-associated guanylate kinase proteins MPP4 and MPP5 associate with Veli3 at distinct intercellular junctions of the neurosensory retina.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in basal part of cell IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cone cell pedicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in rod spherule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
MAGUK p55 subfamily member 4
Names
discs large homolog 6
mDLG6
membrane palmitoylated protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164682.2 → NP_001158154.1  MAGUK p55 subfamily member 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC133162, AC153652
    Consensus CDS
    CCDS48272.1
    UniProtKB/TrEMBL
    D3Z0G8, K3W4N9
    Related
    ENSMUSP00000109914.3, ENSMUST00000114275.9
    Conserved Domains (6) summary
    smart00569
    Location:66 → 100
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12034
    Location:264 → 324
    SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
    smart00072
    Location:454 → 637
    GuKc; Guanylate kinase homologues
    cd00992
    Location:171 → 250
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:446 → 636
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:108 → 154
    L27; L27 domain

  2. NM_145143.3 → NP_660125.2  MAGUK p55 subfamily member 4 isoform 2

    See identical proteins and their annotated locations for NP_660125.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC061694, BI737565
    Consensus CDS
    CCDS48271.1
    UniProtKB/Swiss-Prot
    Q0VG45, Q6P7F1, Q8BTT3, Q8BXM5, Q920P7, Q920P8
    UniProtKB/TrEMBL
    K3W4N9
    Related
    ENSMUSP00000077914.8, ENSMUST00000078874.14
    Conserved Domains (6) summary
    smart00569
    Location:47 → 81
    L27; domain in receptor targeting proteins Lin-2 and Lin-7
    cd12034
    Location:245 → 305
    SH3_MPP4; Src Homology 3 domain of Membrane Protein, Palmitoylated 4 (or MAGUK p55 subfamily member 4)
    smart00072
    Location:435 → 618
    GuKc; Guanylate kinase homologues
    cd00992
    Location:152 → 231
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:427 → 617
    Guanylate_kin; Guanylate kinase
    pfam02828
    Location:89 → 135
    L27; L27 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59160094..59202548 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P7F1.1 GenPept UniProtKB/Swiss-Prot:Q6P7F1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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