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Stradb STE20-related kinase adaptor beta [ Mus musculus (house mouse) ]

Gene ID: 227154, updated on 11-Apr-2024

Summary

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Official Symbol
Stradbprovided by MGI
Official Full Name
STE20-related kinase adaptor betaprovided by MGI
Primary source
MGI:MGI:2144047
See related
Ensembl:ENSMUSG00000026027 AllianceGenome:MGI:2144047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Papk; ILPIP; ILPIPA; Syradb; Als2cr2; D1Ucla2; PRO1038; B830008M19
Summary
Enables protein kinase activity. Acts upstream of or within JNK cascade; cell morphogenesis; and negative regulation of extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be located in aggresome; cytosol; and nucleus. Is expressed in central nervous system; liver; and retina. Orthologous to human STRADB (STE20 related adaptor beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 16.2), heart adult (RPKM 13.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stradb in Genome Data Viewer
Location:
1 C1.3; 1 29.2 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (59012681..59034281)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58973522..58995122)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr1:58854474-58854775 Neighboring gene caspase 8 Neighboring gene predicted gene 28802 Neighboring gene STARR-seq mESC enhancer starr_01024 Neighboring gene STARR-seq mESC enhancer starr_01025 Neighboring gene trafficking protein, kinesin binding 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:59013204-59013435 Neighboring gene STARR-seq mESC enhancer starr_01027 Neighboring gene STARR-positive B cell enhancer ABC_E982 Neighboring gene C2 calcium dependent domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_01029 Neighboring gene predicted gene 29018 Neighboring gene predicted gene, 25502

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of the liver kinase B1-mouse protein-25 -Ste-20-related adaptor protein complex in adult mouse skeletal muscle. Smith CD, et al. J Appl Physiol (1985), 2011 Dec. PMID 21903876, Free PMC Article
  2. Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase. Nishigaki K, et al. J Biol Chem, 2003 Apr 11. PMID 12574163
  3. STRAD pseudokinases regulate axogenesis and LKB1 stability. Veleva-Rotse BO, et al. Neural Dev, 2014 Mar 4. PMID 24594058, Free PMC Article
  4. Localization of the mouse glucocorticoid receptor-interacting protein 1 gene (Grip1) to proximal chromosome 1 by linkage analysis. Welch CL, et al. Mamm Genome, 1997 Aug. PMID 9250876
  5. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Barnes AP, et al. Cell, 2007 May 4. PMID 17482548

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cell morphogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cytoskeleton organization TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of serine/threonine protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
STE20-related kinase adapter protein beta
Names
ILP-interacting protein homolog
STRAD beta
amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog
polyploidy associated protein kinase
pseudokinase ALS2CR2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172656.6 → NP_766244.4  STE20-related kinase adapter protein beta

    See identical proteins and their annotated locations for NP_766244.4

    Status: VALIDATED

    Source sequence(s)
    AI643873, AK080096, AK140272
    Consensus CDS
    CCDS14981.1
    UniProtKB/Swiss-Prot
    Q6P922, Q8BU86, Q8BXK0, Q8K4T2, Q8K4T3
    Related
    ENSMUSP00000027185.5, ENSMUST00000027185.11
    Conserved Domains (2) summary
    smart00220
    Location:58 → 369
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd08226
    Location:59 → 386
    PK_STRAD_beta; Pseudokinase domain of STE20-related kinase adapter protein beta

RNA

  1. NR_151686.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AI643873, AK140272
    Related
    ENSMUST00000123301.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    59012681..59034281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173155.1: Suppressed sequence

    Description
    NM_173155.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4T3.1 GenPept UniProtKB/Swiss-Prot:Q8K4T3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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