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Zfp57 zinc finger protein 57 [ Mus musculus (house mouse) ]

Gene ID: 22715, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp57provided by MGI
Official Full Name
zinc finger protein 57provided by MGI
Primary source
MGI:MGI:99204
See related
Ensembl:ENSMUSG00000036036 AllianceGenome:MGI:99204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G19; Zfp-57
Summary
Enables chromatin binding activity and double-stranded methylated DNA binding activity. Involved in genetic imprinting; maintenance of DNA methylation; and regulation of genetic imprinting. Acts upstream of or within DNA methylation involved in embryo development; genetic imprinting; and negative regulation of transcription by RNA polymerase II. Located in heterochromatin and nucleus. Is expressed in several structures, including early conceptus; genitourinary system; liver; nervous system; and retina. Orthologous to human ZFP57 (ZFP57 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 66.8), CNS E14 (RPKM 62.8) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 19.16 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37307060..37326196)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (37001163..37010729)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_42496 Neighboring gene histocompatibility 2, M region locus 6, pseudogene Neighboring gene RIKEN cDNA 2410137M14 gene Neighboring gene histocompatibility 2, M region locus 4, pseudogene Neighboring gene STARR-seq mESC enhancer starr_42498 Neighboring gene histocompatibility 2, M region locus 5 Neighboring gene STARR-seq mESC enhancer starr_42499 Neighboring gene myelin oligodendrocyte glycoprotein Neighboring gene STARR-seq mESC enhancer starr_42503 Neighboring gene STARR-seq mESC enhancer starr_42504 Neighboring gene gamma-aminobutyric acid type B receptor subunit 1 Neighboring gene STARR-seq mESC enhancer starr_42506 Neighboring gene olfactory receptor family 2 subfamily H member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs. Acurzio B, et al. Sci Rep, 2021 Jul 5. PMID 34226608, Free PMC Article
  2. Imprinted control regions include composite DNA elements consisting of the ZFP57 binding site overlapping MLL1 morphemes. Bina M. Genomics, 2017 Jul. PMID 28476430
  3. ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells. Riso V, et al. Nucleic Acids Res, 2016 Sep 30. PMID 27257070, Free PMC Article
  4. ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells. Anvar Z, et al. Nucleic Acids Res, 2016 Feb 18. PMID 26481358, Free PMC Article
  5. DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å. Liu Y, et al. Biochemistry, 2013 Dec 23. PMID 24236546, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.
    Title: Maternal and zygotic ZFP57 regulate coronary vascular formation and myocardium maturation in mouse embryo.
  2. Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.
    Title: Zfp57 inactivation illustrates the role of ICR methylation in imprinted gene expression during neural differentiation of mouse ESCs.
  3. A group of functionally significant composite DNA elements (ZFP57 binding site (ZFBS)-Morph overlaps) that may play dual roles in the regulation of allele-specific gene expression.
    Title: Imprinted control regions include composite DNA elements consisting of the ZFP57 binding site overlapping MLL1 morphemes.
  4. another function of ZFP57 in early embryogenesis is to repress cis-acting regulatory elements whose activity is not yet required.
    Title: ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells.
  5. Data show that ZFP57 binding is affected by single nucleotide polymorphism (SNPs) and closely associated TGCCGC motif sequences that are present at the target sites.
    Title: ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.
  6. Within established mouse imprinted clusters, ZFP57 specifically binds known or predicted imprinting control region elements, but does not interact with secondary somatically differentially methylated regions (DMRs) or germline DMRs that are not imprinting controlling.
    Title: Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression.
  7. ZFP57 may modulate NOTCH signaling during cardiac development.
    Title: Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development.
  8. Taken together, our results suggest that Nanog positively regulates Zfp57 expression in multiple types of cells.
    Title: Nanog positively regulates Zfp57 expression in mouse embryonic stem cells.
  9. Mouse and human ZFP57 are orthologs despite relatively low sequence identity.
    Title: Human and mouse ZFP57 proteins are functionally interchangeable in maintaining genomic imprinting at multiple imprinted regions in mouse ES cells.
  10. Data suggest that Glu182 in the DNA binding site in zinc finger motif of Zfp57 plays important role in binding specificity and affinity for 5-carboxylcytosine and other cytosine analogs.
    Title: DNA recognition of 5-carboxylcytosine by a Zfp57 mutant at an atomic resolution of 0.97 Å.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within autosome genomic imprinting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autosome genomic imprinting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in autosome genomic imprinting ISO
Inferred from Sequence Orthology
more info
  
involved_in epigenetic programing of female pronucleus IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within epigenetic programming in the zygotic pronuclei IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within genomic imprinting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of gene expression via chromosomal CpG island methylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of heterochromatin IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 57

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013745.2 → NP_001013767.1  zinc finger protein 57 isoform 1

    See identical proteins and their annotated locations for NP_001013767.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC052028, CF731693, CR956641
    Consensus CDS
    CCDS28733.1
    UniProtKB/Swiss-Prot
    Q3UT94, Q62515, Q6JPI1, Q8C6P8
    Related
    ENSMUSP00000065811.8, ENSMUST00000069250.14
    Conserved Domains (4) summary
    smart00349
    Location:15 → 72
    KRAB; krueppel associated box
    COG5048
    Location:139 → 309
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:92 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169 → 190
    zf-C2H2; Zinc finger, C2H2 type

  2. NM_001168501.1 → NP_001161973.1  zinc finger protein 57 isoform 1

    See identical proteins and their annotated locations for NP_001161973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs at the 5' end compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AV579696, BC052028, CR956641
    Consensus CDS
    CCDS28733.1
    UniProtKB/Swiss-Prot
    Q3UT94, Q62515, Q6JPI1, Q8C6P8
    Related
    ENSMUSP00000134418.2, ENSMUST00000174524.8
    Conserved Domains (4) summary
    smart00349
    Location:15 → 72
    KRAB; krueppel associated box
    COG5048
    Location:139 → 309
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:92 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169 → 190
    zf-C2H2; Zinc finger, C2H2 type

  3. NM_001168502.1 → NP_001161974.1  zinc finger protein 57 isoform 2

    See identical proteins and their annotated locations for NP_001161974.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs at the 5' end and uses an alternate, in-frame acceptor splice site at one of the coding exons compared to variant 1. This results in a shorter isoform (2) missing three internal aa compared to isoform 1.
    Source sequence(s)
    AK139625, BC052028, CR956641
    Consensus CDS
    CCDS50106.1
    UniProtKB/Swiss-Prot
    Q8C6P8
    Related
    ENSMUSP00000087414.7, ENSMUST00000089968.13
    Conserved Domains (4) summary
    smart00349
    Location:12 → 69
    KRAB; krueppel associated box
    COG5048
    Location:136 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:89 → 131
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:166 → 187
    zf-C2H2; Zinc finger, C2H2 type

RNA

  1. NR_033137.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs at the 5' end compared to variant 1, and contains an upstream ORF with a strong Kozak signal, which according to leaky scanning model could interfere with the translation of the downstream primary ORF. Translation from the upstream ORF will render this transcript a candidate for nonsense-mediated mRNA decay (NMD). However, this variant transcript is sufficiently abundant to represent as a non-coding RefSeq record.
    Source sequence(s)
    AK143118, BC052028, CR956641

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37307060..37326196
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160583.1 → XP_036016476.1  zinc finger protein 57 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:12 → 69
    KRAB; krueppel associated box
    COG5048
    Location:136 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:89 → 131
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:166 → 187
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_036160582.1 → XP_036016475.1  zinc finger protein 57 isoform X1

    UniProtKB/Swiss-Prot
    Q3UT94, Q62515, Q6JPI1, Q8C6P8
    Conserved Domains (4) summary
    smart00349
    Location:15 → 72
    KRAB; krueppel associated box
    COG5048
    Location:139 → 309
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:92 → 134
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:169 → 190
    zf-C2H2; Zinc finger, C2H2 type

  3. XM_036160584.1 → XP_036016477.1  zinc finger protein 57 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:12 → 69
    KRAB; krueppel associated box
    COG5048
    Location:136 → 306
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:89 → 131
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:166 → 187
    zf-C2H2; Zinc finger, C2H2 type

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_009559.2: Suppressed sequence

    Description
    NM_009559.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C6P8.1 GenPept UniProtKB/Swiss-Prot:Q8C6P8

Gene LinkOut

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