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Nemp2 nuclear envelope integral membrane protein 2 [ Mus musculus (house mouse) ]

Gene ID: 227094, updated on 5-Mar-2024

Summary

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Official Symbol
Nemp2provided by MGI
Official Full Name
nuclear envelope integral membrane protein 2provided by MGI
Primary source
MGI:MGI:2444113
See related
Ensembl:ENSMUSG00000043015 AllianceGenome:MGI:2444113
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tmem194b; 9830163O08; 5330401P04Rik
Summary
Predicted to be located in membrane and nucleus. Predicted to be integral component of membrane. Predicted to be active in nuclear envelope. Orthologous to human NEMP2 (nuclear envelope integral membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 6.7), thymus adult (RPKM 6.5) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Nemp2 in Genome Data Viewer
Location:
1 C1.1; 1 26.99 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (52669850..52691078)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (52568535..52651919)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 53065 Neighboring gene STARR-seq mESC enhancer starr_00902 Neighboring gene predicted gene 28178 Neighboring gene STARR-seq mESC enhancer starr_00903 Neighboring gene predicted gene 5527 Neighboring gene STARR-positive B cell enhancer ABC_E5753 Neighboring gene major facilitator superfamily domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_00904 Neighboring gene STARR-positive B cell enhancer ABC_E3274 Neighboring gene STARR-positive B cell enhancer ABC_E1543 Neighboring gene inositol polyphosphate-1-phosphatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. The Vertebrate Genome Annotation browser 10 years on. Harrow JL, et al. Nucleic Acids Res, 2014 Jan. PMID 24316575, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nuclear envelope integral membrane protein 2
Names
transmembrane protein 194B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142647.1 → NP_001136119.1  nuclear envelope integral membrane protein 2 precursor

    See identical proteins and their annotated locations for NP_001136119.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AI153571, BB848894, BC094370, CD553439
    Consensus CDS
    CCDS48257.1
    UniProtKB/Swiss-Prot
    Q8C844, Q8CB65
    Related
    ENSMUSP00000129351.2, ENSMUST00000165859.8
    Conserved Domains (1) summary
    pfam10225
    Location:142 → 389
    DUF2215; Uncharacterized conserved protein (DUF2215)

RNA

  1. NR_024590.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1, that results in a frameshift. This variant is represented as non-coding because the frameshift renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK036693, BB848894, BC094370

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    52669850..52691078
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_003954987.1 RNA Sequence

    Related
    ENSMUST00000188507.7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_172654.2: Suppressed sequence

    Description
    NM_172654.2: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: LOC423977 (GeneID:423977).
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CB65.3 GenPept UniProtKB/Swiss-Prot:Q8CB65

Gene LinkOut

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