U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp51 zinc finger protein 51 [ Mus musculus (house mouse) ]

Gene ID: 22709, updated on 8-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp51provided by MGI
Official Full Name
zinc finger protein 51provided by MGI
Primary source
MGI:MGI:99198
See related
Ensembl:ENSMUSG00000023892 AllianceGenome:MGI:99198
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp-51; zfec12
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 3.0), placenta adult (RPKM 2.8) and 24 other tissues See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
17 A3.2; 17 11.4 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (21670636..21685853)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (21450374..21465591)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 677 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene zinc finger protein 54 Neighboring gene STARR-seq mESC enhancer starr_42007 Neighboring gene STARR-positive B cell enhancer ABC_E9941 Neighboring gene STARR-positive B cell enhancer ABC_E8655 Neighboring gene STARR-seq mESC enhancer starr_42008 Neighboring gene STARR-seq mESC enhancer starr_42009 Neighboring gene predicted gene, 52290 Neighboring gene STARR-positive B cell enhancer ABC_E3186 Neighboring gene zinc finger protein 53

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Zfp-51, a murine zinc finger encoding gene mapping to the t-complex region of chromosome 17, encodes 19 contiguous zinc fingers and is ubiquitously expressed. Burke PS, et al. Mamm Genome, 1994 Jun. PMID 8043957
  2. Molecular characterization of Zfp54, a zinc-finger-containing gene that is deleted in the embryonic lethal mutation tw18. Shannon M, et al. Mamm Genome, 1999 Jul. PMID 10384051
  3. A cluster of related zinc finger protein genes is deleted in the mouse embryonic lethal mutation tw18. Crossley PH, et al. Proc Natl Acad Sci U S A, 1991 Sep 15. PMID 1680234, Free PMC Article
  4. Physical analysis of the region deleted in the tw18 allele of the mouse tcl-4 complementation group. Barclay J, et al. Genomics, 1996 Aug 15. PMID 8812414
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein 51

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308323.1 → NP_001295252.1  zinc finger protein 51

    See identical proteins and their annotated locations for NP_001295252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK133677, CK390565, CT010433
    Consensus CDS
    CCDS37463.1
    UniProtKB/TrEMBL
    Q3U4L8
    Conserved Domains (4) summary
    COG5048
    Location:327 → 749
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:239 → 318
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:581 → 601
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:42 → 82
    KRAB; KRAB box

  2. NM_009558.4 → NP_033584.3  zinc finger protein 51

    See identical proteins and their annotated locations for NP_033584.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK133677, CK390565, CT010433
    Consensus CDS
    CCDS37463.1
    UniProtKB/TrEMBL
    Q3U4L8
    Related
    ENSMUSP00000045684.6, ENSMUST00000039577.8
    Conserved Domains (4) summary
    COG5048
    Location:327 → 749
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:239 → 318
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:581 → 601
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:42 → 82
    KRAB; KRAB box

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    21670636..21685853
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030249754.1 → XP_030105614.1  zinc finger protein 51 isoform X1

    UniProtKB/TrEMBL
    Q3U4L8
    Conserved Domains (4) summary
    COG5048
    Location:327 → 749
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:239 → 318
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:581 → 601
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:42 → 82
    KRAB; KRAB box
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous