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Zfp41 zinc finger protein 41 [ Mus musculus (house mouse) ]

Gene ID: 22701, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp41provided by MGI
Official Full Name
zinc finger protein 41provided by MGI
Primary source
MGI:MGI:99186
See related
Ensembl:ENSMUSG00000047003 AllianceGenome:MGI:99186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp-41; CTfin92
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation and spermatogenesis. Predicted to be located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; and sensory organ. Orthologous to human ZFP41 (ZFP41 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 18.9), CNS E11.5 (RPKM 18.4) and 24 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 D3; 15 34.62 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (75486972..75501676)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (75615200..75627448)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene lymphocyte antigen 6 family member H Neighboring gene GPI-anchored HDL-binding protein 1 Neighboring gene STARR-positive B cell enhancer ABC_E1174 Neighboring gene STARR-seq mESC enhancer starr_39016 Neighboring gene predicted gene, 46519 Neighboring gene predicted gene, 38506

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of a mouse zinc finger protein gene in both spermatocytes and oocytes during meiosis. Noce T, et al. Dev Biol, 1992 Oct. PMID 1397691
  2. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  3. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
  5. Genomic analysis of mouse retinal development. Blackshaw S, et al. PLoS Biol, 2004 Sep. PMID 15226823, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 41

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044718.3 → NP_001038183.1  zinc finger protein 41

    See identical proteins and their annotated locations for NP_001038183.1

    Status: VALIDATED

    Source sequence(s)
    AC119264
    Consensus CDS
    CCDS37108.1
    UniProtKB/Swiss-Prot
    Q02526, Q8BSV7
    Related
    ENSMUSP00000124626.2, ENSMUST00000161785.8
    Conserved Domains (2) summary
    COG5189
    Location:111 → 191
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001416214.1 → NP_001403143.1  zinc finger protein 41

    Status: VALIDATED

    Source sequence(s)
    AC119264
    UniProtKB/Swiss-Prot
    Q02526, Q8BSV7

  3. NM_001416215.1 → NP_001403144.1  zinc finger protein 41

    Status: VALIDATED

    Source sequence(s)
    AC119264
    UniProtKB/Swiss-Prot
    Q02526, Q8BSV7

  4. NM_001416216.1 → NP_001403145.1  zinc finger protein 41

    Status: VALIDATED

    Source sequence(s)
    AC119264
    UniProtKB/Swiss-Prot
    Q02526, Q8BSV7

  5. NM_001416217.1 → NP_001403146.1  zinc finger protein 41

    Status: VALIDATED

    Source sequence(s)
    AC119264
    UniProtKB/Swiss-Prot
    Q02526, Q8BSV7

  6. NM_011759.4 → NP_035889.1  zinc finger protein 41

    See identical proteins and their annotated locations for NP_035889.1

    Status: VALIDATED

    Source sequence(s)
    AC119264
    Consensus CDS
    CCDS37108.1
    UniProtKB/Swiss-Prot
    Q02526, Q8BSV7
    Related
    ENSMUSP00000056510.8, ENSMUST00000054555.10
    Conserved Domains (2) summary
    COG5189
    Location:111 → 191
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:117 → 137
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_183609.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC119264

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    75486972..75501676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q02526.2 GenPept UniProtKB/Swiss-Prot:Q02526

Gene LinkOut

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