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Actr1b ARP1 actin-related protein 1B, centractin beta [ Mus musculus (house mouse) ]

Gene ID: 226977, updated on 11-Apr-2024

Summary

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Official Symbol
Actr1bprovided by MGI
Official Full Name
ARP1 actin-related protein 1B, centractin betaprovided by MGI
Primary source
MGI:MGI:1917446
See related
Ensembl:ENSMUSG00000037351 AllianceGenome:MGI:1917446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arp1b; 2310066K23Rik
Summary
Predicted to enable ATP binding activity. Predicted to be located in centrosome and cytoplasm. Is expressed in olfactory epithelium and vomeronasal organ. Orthologous to human ACTR1B (actin related protein 1B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 55.7), cerebellum adult (RPKM 47.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Actr1b in Genome Data Viewer
Location:
1 B; 1 15.38 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36737195..36749051, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36698114..36710017, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 178, member B Neighboring gene STARR-seq mESC enhancer starr_00646 Neighboring gene RIKEN cDNA 4933424G06 gene Neighboring gene STARR-positive B cell enhancer ABC_E1539 Neighboring gene cytochrome c oxidase subunit 5B Neighboring gene predicted gene, 33533 Neighboring gene predicted gene, 18828 Neighboring gene zeta-chain (TCR) associated protein kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular evolution of the actin family. Goodson HV, et al. J Cell Sci, 2002 Jul 1. PMID 12077353
  2. Endogenously nitrated proteins in mouse brain: links to neurodegenerative disease. Sacksteder CA, et al. Biochemistry, 2006 Jul 4. PMID 16800626
  3. Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo. O'Brien R, et al. J Biol Chem, 2015 Jul 31. PMID 26025364, Free PMC Article
  4. Dynamin-1 co-associates with native mouse brain BKCa channels: proteomics analysis of synaptic protein complexes. Gorini G, et al. FEBS Lett, 2010 Mar 5. PMID 20114047, Free PMC Article
  5. A generic approach for the purification of signaling complexes that specifically interact with the carboxyl-terminal domain of G protein-coupled receptors. Maurice P, et al. Mol Cell Proteomics, 2008 Aug. PMID 18448421, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC36526

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of dynactin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-centractin
Names
ARP1 actin-related protein 1 homolog B, centractin beta
actin-related protein 1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418135.1 → NP_001405064.1  beta-centractin isoform a

    Status: VALIDATED

    Source sequence(s)
    AC084389

  2. NM_001418136.1 → NP_001405065.1  beta-centractin isoform c

    Status: VALIDATED

    Source sequence(s)
    AC084389

  3. NM_001418137.1 → NP_001405066.1  beta-centractin isoform d

    Status: VALIDATED

    Source sequence(s)
    AC084389

  4. NM_001418138.1 → NP_001405067.1  beta-centractin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC084389

  5. NM_001418139.1 → NP_001405068.1  beta-centractin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC084389

  6. NM_001418140.1 → NP_001405069.1  beta-centractin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC084389

  7. NM_001418141.1 → NP_001405070.1  beta-centractin isoform e

    Status: VALIDATED

    Source sequence(s)
    AC084389

  8. NM_001418142.1 → NP_001405071.1  beta-centractin isoform f

    Status: VALIDATED

    Source sequence(s)
    AC084389

  9. NM_001418143.1 → NP_001405072.1  beta-centractin isoform g

    Status: VALIDATED

    Source sequence(s)
    AC084389

  10. NM_001418144.1 → NP_001405073.1  beta-centractin isoform h

    Status: VALIDATED

    Source sequence(s)
    AC084389

  11. NM_146107.3 → NP_666219.1  beta-centractin isoform b

    See identical proteins and their annotated locations for NP_666219.1

    Status: VALIDATED

    Source sequence(s)
    AC084389
    Consensus CDS
    CCDS14887.1
    UniProtKB/Swiss-Prot
    Q8R5C5
    Related
    ENSMUSP00000047326.4, ENSMUST00000043951.10
    Conserved Domains (1) summary
    cl17037
    Location:5 → 376
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36737195..36749051 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164312.1 → XP_036020205.1  beta-centractin isoform X2

    Conserved Domains (1) summary
    cl17037
    Location:1 → 302
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5C5.1 GenPept UniProtKB/Swiss-Prot:Q8R5C5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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