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Kcnq5 potassium voltage-gated channel, subfamily Q, member 5 [ Mus musculus (house mouse) ]

Gene ID: 226922, updated on 18-Apr-2024

Summary

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Official Symbol
Kcnq5provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily Q, member 5provided by MGI
Primary source
MGI:MGI:1924937
See related
Ensembl:ENSMUSG00000028033 AllianceGenome:MGI:1924937
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D1Mgi1; 7730402H11; 9230107O05Rik
Summary
Enables voltage-gated potassium channel activity. Acts upstream of or within potassium ion transport. Predicted to be integral component of plasma membrane. Predicted to be part of clathrin coat and voltage-gated potassium channel complex. Predicted to be integral component of membrane. Is expressed in heart. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 46. Orthologous to human KCNQ5 (potassium voltage-gated channel subfamily Q member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 3.9), frontal lobe adult (RPKM 3.2) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 A4; 1 6.67 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (21468623..22032874, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (21398399..21962650, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:21459459-21459687 Neighboring gene predicted gene, 33147 Neighboring gene KH domain containing 1 pseudogene Neighboring gene KH domain containing 1B Neighboring gene STARR-seq mESC enhancer starr_00409 Neighboring gene STARR-seq mESC enhancer starr_00410 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene STARR-seq mESC enhancer starr_00411 Neighboring gene STARR-seq mESC enhancer starr_00412 Neighboring gene predicted gene, 53539 Neighboring gene STARR-seq mESC enhancer starr_00414 Neighboring gene transmembrane emp24 domain trafficking protein 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_00415 Neighboring gene STARR-seq mESC enhancer starr_00416 Neighboring gene STARR-seq mESC enhancer starr_00417 Neighboring gene regulating synaptic membrane exocytosis 1 Neighboring gene STARR-seq mESC enhancer starr_00419 Neighboring gene STARR-seq mESC enhancer starr_00422

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus. Tzingounis AV, et al. Proc Natl Acad Sci U S A, 2010 Jun 1. PMID 20534576, Free PMC Article
  2. KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3. Soh H, et al. Proc Natl Acad Sci U S A, 2022 Mar 29. PMID 35320039, Free PMC Article
  3. KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations. Fidzinski P, et al. Nat Commun, 2015 Feb 4. PMID 25649132
  4. Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models. Spitzmaul G, et al. J Biol Chem, 2013 Mar 29. PMID 23408425, Free PMC Article
  5. Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles. Jepps TA, et al. Am J Physiol Gastrointest Liver Physiol, 2009 Jul. PMID 19389803, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation.
    Title: KCNQ5 Controls Perivascular Adipose Tissue-Mediated Vasodilation.
  2. KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
    Title: KCNQ2 and KCNQ5 form heteromeric channels independent of KCNQ3.
  3. KCNQ5 controls excitability and function of hippocampal networks through modulation of synaptic inhibition.
    Title: KCNQ5 K(+) channels control hippocampal synaptic inhibition and fast network oscillations.
  4. analysis of the vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models
    Title: Vestibular role of KCNQ4 and KCNQ5 K+ channels revealed by mouse models.
  5. Data show that in early pregnant mouse myometrium, the relative abundance of mRNA expression was KCNQ3 > KCNQ4 > KCNQ5 > KCNQ1 > KCNQ2.
    Title: The contribution of Kv7 channels to pregnant mouse and human myometrial contractility.
  6. Kcnq5(dn/dn) mice are viable and have normal brain morphology. However, in the CA3 area of hippocampus, a region that highly expresses KCNQ5 channels, the medium and slow afterhyperpolarization currents are significantly reduced.
    Title: The KCNQ5 potassium channel mediates a component of the afterhyperpolarization current in mouse hippocampus.
  7. K(v)7.4 and K(v)7.5 are expressed in different regions of the murine gastrointestinal tract and blockers of K(v)7 channels augment inherent contractile activity.
    Title: Molecular and functional characterization of Kv7 K+ channel in murine gastrointestinal smooth muscles.
  8. Results provide support for KCNQ4- or KCNQ5-encoded channels having an important functional impact in the vasculature.
    Title: Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents.
  9. These data represent an exhaustive characterisation of a truncated KCNQ5 splice variant that may contribute to the native XE991-sensitive channel in murine vasculature.
    Title: Expression profile and characterisation of a truncated KCNQ5 splice variant.
  10. Murine blood vessels exhibit a distinctive expression profile of KCNQ1, KCNQ4, and KCNQ5, with 'neuronal' KCNQ4 dominating
    Title: Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated potassium channel activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within potassium ion transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
part_of clathrin coat ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily KQT member 5
Names
KQT-like 5
potassium channel subunit alpha KvLQT5
voltage-gated potassium channel subunit Kv7.5
voltage-gated potassium channel type Kv7.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160139.1 → NP_001153611.1  potassium voltage-gated channel subfamily KQT member 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer protein (isoform 1).
    Source sequence(s)
    AK147264, AW493240, BE648243, CX239866
    Consensus CDS
    CCDS48230.1
    UniProtKB/TrEMBL
    E9Q9F1, G3UYP4
    Related
    ENSMUSP00000110955.2, ENSMUST00000115300.8
    Conserved Domains (3) summary
    pfam00520
    Location:161 → 359
    Ion_trans; Ion transport protein
    pfam03520
    Location:473 → 660
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:275 → 349
    Ion_trans_2; Ion channel

  2. NM_001310477.1 → NP_001297406.1  potassium voltage-gated channel subfamily KQT member 5 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) omits two in-frame coding exons, compared to variant 1, resulting in a shorter protein (isoform 3).
    Source sequence(s)
    AC115920, AC125483, AC131088
    Consensus CDS
    CCDS78554.1
    UniProtKB/TrEMBL
    G3UYG5, G3UYP4
    Related
    ENSMUSP00000134076.2, ENSMUST00000173404.2
    Conserved Domains (3) summary
    pfam00520
    Location:161 → 359
    Ion_trans; Ion transport protein
    pfam03520
    Location:445 → 632
    KCNQ_channel; KCNQ voltage-gated potassium channel
    pfam07885
    Location:275 → 349
    Ion_trans_2; Ion channel

  3. NM_023872.3 → NP_076361.1  potassium voltage-gated channel subfamily KQT member 5 isoform 2

    See identical proteins and their annotated locations for NP_076361.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) omits an in-frame coding exon, compared to variant 1, resulting in a shorter protein (isoform 2).
    Source sequence(s)
    AK147264, AW493240, AY679158, BE648243, CX239866
    Consensus CDS
    CCDS35525.1
    UniProtKB/Swiss-Prot
    Q4QXS5, Q8BSF6, Q9JK45
    UniProtKB/TrEMBL
    G3UYP4
    Related
    ENSMUSP00000029667.7, ENSMUST00000029667.13
    Conserved Domains (2) summary
    pfam00520
    Location:127 → 359
    Ion_trans; Ion transport protein
    pfam03520
    Location:448 → 635
    KCNQ_channel; KCNQ voltage-gated potassium channel

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    21468623..22032874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164276.1 → XP_036020169.1  potassium voltage-gated channel subfamily KQT member 5 isoform X1

    UniProtKB/TrEMBL
    G3UYP4
    Conserved Domains (2) summary
    pfam00520
    Location:5 → 229
    Ion_trans; Ion transport protein
    pfam03520
    Location:337 → 524
    KCNQ_channel; KCNQ voltage-gated potassium channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JK45.2 GenPept UniProtKB/Swiss-Prot:Q9JK45

Gene LinkOut

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