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Zfp26 zinc finger protein 26 [ Mus musculus (house mouse) ]

Gene ID: 22688, updated on 11-Apr-2024

Summary

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Official Symbol
Zfp26provided by MGI
Official Full Name
zinc finger protein 26provided by MGI
Primary source
MGI:MGI:99173
See related
Ensembl:ENSMUSG00000063108 AllianceGenome:MGI:99173
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp70; mkr-3; KRAB15; Zfp-26; mszf14; mszf52; Zfp81-rs1; mKIAA4196; 5033428C05Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including gonad; liver; lung; spinal cord ventricular layer; and spleen. Orthologous to several human genes including ZNF624 (zinc finger protein 624); ZNF778 (zinc finger protein 778); and ZNF814 (zinc finger protein 814). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 4.4), whole brain E14.5 (RPKM 4.2) and 23 other tissues See more
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Genomic context

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Location:
9 A3; 9 7.55 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20338457..20371465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20428318..20460169, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_23456 Neighboring gene olfactory receptor family 7 subfamily E member 178 Neighboring gene zinc finger protein 560 Neighboring gene STARR-positive B cell enhancer ABC_E9752 Neighboring gene STARR-positive B cell enhancer ABC_E9753 Neighboring gene zinc finger protein 426 Neighboring gene predicted gene, 23316 Neighboring gene zinc finger protein 266

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Specific and ubiquitous expression of different Zn finger protein genes in the mouse. Chowdhury K, et al. Nucleic Acids Res, 1988 Nov 11. PMID 3143103, Free PMC Article
  2. Emergence of the ZNF91 Krüppel-associated box-containing zinc finger gene family in the last common ancestor of anthropoidea. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1995 Nov 7. PMID 7479878, Free PMC Article
  3. Activation of the c-H-ras proto-oncogene by retrovirus insertion and chromosomal rearrangement in a Moloney leukemia virus-induced T-cell leukemia. Ihle JN, et al. J Virol, 1989 Jul. PMID 2542606, Free PMC Article
  4. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  5. Characterization of the mid-foregut transcriptome identifies genes regulated during lung bud induction. Millien G, et al. Gene Expr Patterns, 2008 Jan. PMID 18023262, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • KIAA4196

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 26
Names
protein mKR3
zinc finger protein 81, related sequence 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357809.2 → NP_001344738.1  zinc finger protein 26 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC171206
    Consensus CDS
    CCDS40543.2
    UniProtKB/TrEMBL
    G3XA08
    Conserved Domains (3) summary
    smart00349
    Location:107 → 165
    KRAB; krueppel associated box
    COG5048
    Location:319 → 754
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001407538.1 → NP_001394467.1  zinc finger protein 26 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC171206
    UniProtKB/TrEMBL
    G3XA08

  3. NM_001407539.1 → NP_001394468.1  zinc finger protein 26 isoform a

    Status: VALIDATED

    Source sequence(s)
    AC171206
    UniProtKB/TrEMBL
    G3XA08

  4. NM_001407540.1 → NP_001394469.1  zinc finger protein 26 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171206

  5. NM_001407541.1 → NP_001394470.1  zinc finger protein 26 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171206

  6. NM_001407542.1 → NP_001394471.1  zinc finger protein 26 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC171206

  7. NM_001407543.1 → NP_001394472.1  zinc finger protein 26 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171206

  8. NM_001407544.1 → NP_001394473.1  zinc finger protein 26 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC171206

  9. NM_001407545.1 → NP_001394474.1  zinc finger protein 26 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171206

  10. NM_001407546.1 → NP_001394475.1  zinc finger protein 26 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC171206

  11. NM_001407547.1 → NP_001394476.1  zinc finger protein 26 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC171206

  12. NM_001407548.1 → NP_001394477.1  zinc finger protein 26 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC171206

  13. NM_001407549.1 → NP_001394478.1  zinc finger protein 26 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC171206

  14. NM_001407550.1 → NP_001394479.1  zinc finger protein 26 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC171206

  15. NM_011753.4 → NP_035883.2  zinc finger protein 26 isoform a

    See identical proteins and their annotated locations for NP_035883.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same isoform (a).
    Source sequence(s)
    AC171206
    Consensus CDS
    CCDS40543.2
    UniProtKB/TrEMBL
    G3XA08
    Related
    ENSMUSP00000124075.2, ENSMUST00000159569.9
    Conserved Domains (3) summary
    smart00349
    Location:107 → 165
    KRAB; krueppel associated box
    COG5048
    Location:319 → 754
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]

RNA

  1. NR_176386.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171206

  2. NR_176387.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171206

  3. NR_176388.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171206

  4. NR_176389.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171206

  5. NR_176390.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171206

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20338457..20371465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244255.2 → XP_030100115.1  zinc finger protein 26 isoform X6

    Conserved Domains (3) summary
    COG5048
    Location:92 → 523
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:40 → 60
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:528 → 552
    zf-H2C2_2; Zinc-finger double domain

  2. XM_011242456.3 → XP_011240758.1  zinc finger protein 26 isoform X2

    See identical proteins and their annotated locations for XP_011240758.1

    UniProtKB/TrEMBL
    G3XA08
    Conserved Domains (3) summary
    smart00349
    Location:107 → 165
    KRAB; krueppel associated box
    COG5048
    Location:319 → 754
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:402 → 422
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_011242454.4 → XP_011240756.1  zinc finger protein 26 isoform X1

    See identical proteins and their annotated locations for XP_011240756.1

    Conserved Domains (3) summary
    smart00349
    Location:113 → 171
    KRAB; krueppel associated box
    COG5048
    Location:325 → 760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:408 → 428
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_011242453.3 → XP_011240755.1  zinc finger protein 26 isoform X1

    See identical proteins and their annotated locations for XP_011240755.1

    Conserved Domains (3) summary
    smart00349
    Location:113 → 171
    KRAB; krueppel associated box
    COG5048
    Location:325 → 760
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:408 → 428
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_017313287.3 → XP_017168776.1  zinc finger protein 26 isoform X3

    Conserved Domains (3) summary
    smart00349
    Location:85 → 143
    KRAB; krueppel associated box
    COG5048
    Location:297 → 732
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10076.2 GenPept UniProtKB/Swiss-Prot:P10076

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