Vash2 vasohibin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Vash2provided by MGI
Official Full Name: vasohibin 2provided by MGI
Primary source: MGI:MGI:2444826
See related: Ensembl:ENSMUSG00000037568 AllianceGenome:MGI:2444826
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: B130052G07Rik
Summary: Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development; positive regulation of angiogenesis; and syncytium formation by plasma membrane fusion. Predicted to be located in cytoskeleton and extracellular region. Predicted to be active in cytoplasm. Is expressed in brain and hippocampus. Orthologous to human VASH2 (vasohibin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in testis adult (RPKM 24.2), CNS E18 (RPKM 15.9) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H6; 1 96.28 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (190679843..190711500, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (190947646..190979368, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Deletion of Vasohibin-2 Exacerbates Ischemia-Reperfusion-Induced Acute Kidney Injury.
Title: Genetic Deletion of Vasohibin-2 Exacerbates Ischemia-Reperfusion-Induced Acute Kidney Injury.
High VASH2 expression is associated with diabetes-induced glomerular alterations, particularly impaired filtration barrier and mesangial expansion.
Title: Deletion of pro-angiogenic factor vasohibin-2 ameliorates glomerular alterations in a mouse diabetic nephropathy model.
These results suggest that VASH2 plays an important role in gastric tumor progression via the accumulation of cancer-associated fibroblasts
Title: Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts.
VASH2 drives breast cancer cells to undergo EMT by activation of the TGFbeta1 pathway and hypoxia dependent repression GATA3-ESR1 pathway, leading to cancer metastasis.
Title: Vasohibin 2 promotes epithelial-mesenchymal transition in human breast cancer via activation of transforming growth factor β 1 and hypoxia dependent repression of GATA-binding factor 3.
VASH1 and VASH2 showed distinctive localization and opposing function on the fetoplacental vascularization.
Title: Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation.
VASH2 may modulate the onset of tumors in the gastrointestinal tract by regulating tumor angiogenesis.
Title: Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis.
Loss of vasohibin-2 is associated with deficient angiogenesis in the termination sprouting front of endothelial cells.
Title: Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	ISO Inferred from Sequence Orthology more info
enables carboxypeptidase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metallocarboxypeptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables metallocarboxypeptidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables metallocarboxypeptidase activity	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin-tyrosine carboxypeptidase	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-cell fusion	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within labyrinthine layer blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within labyrinthine layer development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within placenta blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within positive regulation of endothelial cell proliferation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in proteolysis	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within syncytium formation by plasma membrane fusion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: tubulinyl-Tyr carboxypeptidase 2

Names: vasohibin-like protein

NP_659128.2

EC 3.4.17.17

XP_006497212.1

EC 3.4.17.17

XP_006497213.1

EC 3.4.17.17

XP_011237215.1

EC 3.4.17.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144879.2 → NP_659128.2 tubulinyl-Tyr carboxypeptidase 2

See identical proteins and their annotated locations for NP_659128.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and is protein-coding.

Source sequence(s)

AK140989, AW488800, BB840589

Consensus CDS

CCDS48482.1

UniProtKB/Swiss-Prot

Q3TR02, Q8BRA1, Q8C5G2, Q8R1R8

Related

ENSMUSP00000036768.7, ENSMUST00000047409.9

Conserved Domains (1) summary

pfam14822
Location:47 → 291

Vasohibin

RNA

NR_027352.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it contains a regulatory upstream ORF that is likely to inhibit the translation of the supported primary ORF, as represented in variant 1.

Source sequence(s)

AK078596, AK140989, AK163193, AW488800