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Smyd2 SET and MYND domain containing 2 [ Mus musculus (house mouse) ]

Gene ID: 226830, updated on 21-Apr-2024

Summary

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Official Symbol
Smyd2provided by MGI
Official Full Name
SET and MYND domain containing 2provided by MGI
Primary source
MGI:MGI:1915889
See related
Ensembl:ENSMUSG00000026603 AllianceGenome:MGI:1915889
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KMT3C; Zmynd14; 4930402C15; 1110020E07Rik
Summary
Enables RNA polymerase II complex binding activity and histone methyltransferase activity (H3-K36 specific). Involved in negative regulation of cell population proliferation and peptidyl-lysine dimethylation. Acts upstream of or within histone methylation. Located in cytosol and nucleus. Is expressed in several structures, including heart; hemolymphoid system gland; nasal cavity epithelium; nervous system; and retina. Orthologous to human SMYD2 (SET and MYND domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 31.3), heart adult (RPKM 30.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H6; 1 95.03 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (189612689..189654758, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (189880492..189922495, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase, non-receptor type 14 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191654884-191655189 Neighboring gene STARR-seq mESC enhancer starr_03408 Neighboring gene STARR-seq mESC enhancer starr_03409 Neighboring gene predicted gene, 30280 Neighboring gene predicted gene, 26574 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:191691042-191691151 Neighboring gene STARR-seq mESC enhancer starr_03412 Neighboring gene STARR-seq mESC enhancer starr_03413 Neighboring gene STARR-positive B cell enhancer mm9_chr1:191796963-191797263 Neighboring gene STARR-seq mESC enhancer starr_03414 Neighboring gene predicted gene, 39736 Neighboring gene predicted gene, 30446

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis. Liu L, et al. FASEB J, 2021 Jul. PMID 34143514, Free PMC Article
  2. Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation. Su H, et al. Cell Death Dis, 2022 Oct 21. PMID 36270984, Free PMC Article
  3. Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke. Wang J, et al. Clin Transl Med, 2022 Mar. PMID 35297562, Free PMC Article
  4. SMYD2 suppresses p53 activity to promote glucose metabolism in cervical cancer. Wang Y, et al. Exp Cell Res, 2021 Jul 15. PMID 34015314
  5. Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease. Li LX, et al. J Clin Invest, 2017 Jun 30. PMID 28604386, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide.
    Title: Lysine methyltransferase SMYD2 enhances androgen receptor signaling to modulate CRPC cell resistance to enzalutamide.
  2. SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
    Title: SMYD2 regulates vascular smooth muscle cell phenotypic switching and intimal hyperplasia via interaction with myocardin.
  3. Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
    Title: Histone methyltransferase Smyd2 drives adipogenesis via regulating STAT3 phosphorylation.
  4. Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke.
    Title: Histone methyltransferase Smyd2 contributes to blood-brain barrier breakdown in stroke.
  5. SMYD2 suppresses p53 activity to promote glucose metabolism in cervical cancer.
    Title: SMYD2 suppresses p53 activity to promote glucose metabolism in cervical cancer.
  6. Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.
    Title: Critical roles of SMYD2 lysine methyltransferase in mediating renal fibroblast activation and kidney fibrosis.
  7. Our data indicate that Smyd2 has a critical role downstream of Myc in acute myeloid leukemia
    Title: Smyd2 is a Myc-regulated gene critical for MLL-AF9 induced leukemogenesis.
  8. two positive feedback loops that integrate epigenetic regulation and renal inflammation in cyst development: SMYD2/IL-6/STAT3/SMYD2 and SMYD2/TNF-alpha/NF-kappaB/SMYD2.
    Title: Lysine methyltransferase SMYD2 promotes cyst growth in autosomal dominant polycystic kidney disease.
  9. a pivotal role for SMYD2 in promoting pancreatic cancer.
    Title: Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer.
  10. Data show that histone methyltransferase Smyd2 inhibits macrophage interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-alpha) production. production.
    Title: The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) production.
Submit: New GeneRIF Correction See all GeneRIFs (14)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA polymerase II complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K36 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone H3K4 trimethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables histone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables p53 binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-lysine N-methyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chromatin remodeling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-lysine dimethylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidyl-lysine monomethylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
N-lysine methyltransferase SMYD2
Names
SET and MYND domain-containing protein 2
histone methyltransferase SMYD2
NP_081072.1
XP_006497209.1
XP_006497210.1
XP_017175675.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026796.2 → NP_081072.1  N-lysine methyltransferase SMYD2

    See identical proteins and their annotated locations for NP_081072.1

    Status: VALIDATED

    Source sequence(s)
    AC140250, AK003853, AK150857, W76826
    Consensus CDS
    CCDS35821.1
    UniProtKB/Swiss-Prot
    Q3UBQ2, Q8R5A0
    Related
    ENSMUSP00000027897.8, ENSMUST00000027897.8
    Conserved Domains (3) summary
    pfam13424
    Location:381 → 426
    TPR_12; Tetratricopeptide repeat
    cd19202
    Location:7 → 269
    SET_SMYD2; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins
    pfam01753
    Location:52 → 90
    zf-MYND; MYND finger

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    189612689..189654758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497146.5 → XP_006497209.1  N-lysine methyltransferase SMYD2 isoform X1

    Conserved Domains (2) summary
    pfam13424
    Location:344 → 389
    TPR_12; Tetratricopeptide repeat
    cd19202
    Location:7 → 232
    SET_SMYD2; SET domain (including post-SET domain) found in SET and MYND domain-containing protein 2 (SMYD2) and similar proteins

  2. XM_017320186.1 → XP_017175675.1  N-lysine methyltransferase SMYD2 isoform X3

    UniProtKB/TrEMBL
    Q9D177
    Conserved Domains (2) summary
    pfam13424
    Location:177 → 222
    TPR_12; Tetratricopeptide repeat
    cl40432
    Location:1 → 65
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily

  3. XM_006497147.5 → XP_006497210.1  N-lysine methyltransferase SMYD2 isoform X2

    Conserved Domains (2) summary
    pfam01753
    Location:52 → 90
    zf-MYND; MYND finger
    cl40432
    Location:7 → 178
    SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8R5A0.1 GenPept UniProtKB/Swiss-Prot:Q8R5A0

Gene LinkOut

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