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Kctd3 potassium channel tetramerisation domain containing 3 [ Mus musculus (house mouse) ]

Gene ID: 226823, updated on 5-Mar-2024

Summary

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Official Symbol
Kctd3provided by MGI
Official Full Name
potassium channel tetramerisation domain containing 3provided by MGI
Primary source
MGI:MGI:2444629
See related
Ensembl:ENSMUSG00000026608 AllianceGenome:MGI:2444629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NY-REN-45; 9330185B06; 4930438A20Rik; E330032J19Rik
Summary
Predicted to be involved in protein homooligomerization. Located in plasma membrane. Orthologous to human KCTD3 (potassium channel tetramerization domain containing 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 20.9), CNS E14 (RPKM 16.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Kctd3 in Genome Data Viewer
Location:
1 H6; 1 93.51 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (188703292..188740095, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (188971095..189007898, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene predicted gene, 25269 Neighboring gene STARR-seq mESC enhancer starr_03379 Neighboring gene STARR-seq mESC enhancer starr_03380 Neighboring gene nuclear encoded tRNA asparagine 3 (anticodon GTT) Neighboring gene STARR-seq mESC enhancer starr_03383 Neighboring gene STARR-seq mESC enhancer starr_03385 Neighboring gene STARR-seq mESC enhancer starr_03387 Neighboring gene STARR-seq mESC enhancer starr_03388 Neighboring gene STARR-seq mESC enhancer starr_03389 Neighboring gene STARR-seq mESC enhancer starr_03390 Neighboring gene STARR-seq mESC enhancer starr_03391 Neighboring gene predicted gene, 36561 Neighboring gene N-acetylneuraminic acid phosphatase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3). Cao-Ehlker X, et al. J Biol Chem, 2013 Mar 15. PMID 23382386, Free PMC Article
  2. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
  5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KCTD3 is an accessory subunit of native HCN3 complexes
    Title: Up-regulation of hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) by specific interaction with K+ channel tetramerization domain-containing protein 3 (KCTD3).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BTB/POZ domain-containing protein KCTD3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359576.1 → NP_001346505.1  BTB/POZ domain-containing protein KCTD3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC129312
    Conserved Domains (1) summary
    pfam02214
    Location:20 → 105
    BTB_2; BTB/POZ domain

  2. NM_001359577.1 → NP_001346506.1  BTB/POZ domain-containing protein KCTD3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC129312
    Conserved Domains (1) summary
    pfam02214
    Location:20 → 105
    BTB_2; BTB/POZ domain

  3. NM_001359578.1 → NP_001346507.1  BTB/POZ domain-containing protein KCTD3 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC129312

  4. NM_172650.2 → NP_766238.1  BTB/POZ domain-containing protein KCTD3 isoform 1

    See identical proteins and their annotated locations for NP_766238.1

    Status: VALIDATED

    Source sequence(s)
    AK033491, AK034380, AK087865
    Consensus CDS
    CCDS15608.1
    UniProtKB/Swiss-Prot
    Q6P7X4, Q8BFX3
    Related
    ENSMUSP00000082821.3, ENSMUST00000085678.8
    Conserved Domains (3) summary
    smart00225
    Location:20 → 114
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam02214
    Location:20 → 105
    BTB_2; BTB/POZ domain
    cl02567
    Location:246 → 448
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_153196.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC129312

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    188703292..188740095 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253563.2 → XP_030109423.1  BTB/POZ domain-containing protein KCTD3 isoform X3

  2. XM_036164222.1 → XP_036020115.1  BTB/POZ domain-containing protein KCTD3 isoform X2

  3. XM_036164219.1 → XP_036020112.1  BTB/POZ domain-containing protein KCTD3 isoform X1

    Conserved Domains (1) summary
    cl38908
    Location:21 → 53
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily

  4. XM_017320182.1 → XP_017175671.1  BTB/POZ domain-containing protein KCTD3 isoform X5

  5. XM_017320175.1 → XP_017175664.1  BTB/POZ domain-containing protein KCTD3 isoform X4

RNA

  1. XR_001784135.2 RNA Sequence

  2. XR_373771.4 RNA Sequence

  3. XR_001784133.2 RNA Sequence

  4. XR_001784131.2 RNA Sequence

  5. XR_003954946.1 RNA Sequence

    Related
    ENSMUST00000193143.6
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BFX3.1 GenPept UniProtKB/Swiss-Prot:Q8BFX3

Gene LinkOut

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