Slc30a10 solute carrier family 30, member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc30a10provided by MGI
Official Full Name: solute carrier family 30, member 10provided by MGI
Primary source: MGI:MGI:2685058
See related: Ensembl:ENSMUSG00000026614 AllianceGenome:MGI:2685058
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm212; E130106K10Rik
Summary: Predicted to enable zinc ion transmembrane transporter activity. Predicted to be involved in several processes, including detoxification of zinc ion; inorganic cation transmembrane transport; and negative regulation of cellular senescence. Predicted to act upstream of or within zinc ion transport. Predicted to be located in early endosome and recycling endosome. Predicted to be integral component of membrane. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in hypermanganesemia with dystonia 1. Orthologous to human SLC30A10 (solute carrier family 30 member 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 19.5), liver E14.5 (RPKM 16.9) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 H5; 1 89.53 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (185187045..185200959)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (185454848..185468762)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AAV-mediated hepatic expression of SLC30A10 and the Thr95Ile variant attenuates manganese excess and other phenotypes in Slc30a10-deficient mice.
Title: AAV-mediated hepatic expression of SLC30A10 and the Thr95Ile variant attenuates manganese excess and other phenotypes in Slc30a10-deficient mice.
Loss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice.
Title: Loss of SLC30A10 manganese transporter alters expression of neurotransmission genes and activates hypoxia-inducible factor signaling in mice.
Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure.
Title: Differential expression of SLC30A10 and RAGE in mouse pups by early life lead exposure.
Bile acid composition regulates the manganese transporter Slc30a10 in intestine.
Title: Bile acid composition regulates the manganese transporter Slc30a10 in intestine.
Slc30a10 is essential for Mn excretion by hepatocytes and enterocytes and could be an effective target for pharmacological intervention to treat Mn toxicity.
Title: Manganese transporter Slc30a10 controls physiological manganese excretion and toxicity.
when manganese levels increase, activity of SLC30A10 in the brain protects against neurotoxicity
Title: SLC30A10 transporter in the digestive system regulates brain manganese under basal conditions while brain SLC30A10 protects against neurotoxicity.
the hypothyroidism phenotype of Slc30a10 single knockouts is induced by elevated thyroid manganese, which blocks thyroxine production. These findings provide new insights into the mechanisms of manganese detoxification and manganese-induced thyroid dysfunction.
Title: Hypothyroidism induced by loss of the manganese efflux transporter SLC30A10 may be explained by reduced thyroxine production.
SLC30A10 has a protective role in 1-methyl-4-phenylpyridinium-induced toxicity via PERK-ATF4 pathway.
Title: Protective function of SLC30A10 induced via PERK-ATF4 pathway against 1-methyl-4-phenylpyridinium.
discovery highlights the importance of determining the role of thyroid dysfunction in the onset and progression of manganese-induced disease and identifies Slc30a10 knock-out mice as a new model for studying thyroid biology.
Title: Deficiency in the manganese efflux transporter SLC30A10 induces severe hypothyroidism in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:547077

Slc30a10 (e-PCR), detects polymorphism
- UniSTS:547077

NoName (e-PCR)
- UniSTS:234298

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium:manganese antiporter activity	ISO Inferred from Sequence Orthology more info
enables manganese ion transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables monoatomic cation transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to angiotensin	ISO Inferred from Sequence Orthology more info
involved_in detoxification of zinc ion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular manganese ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion export across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in manganese ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in manganese ion transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in zinc ion import into organelle	ISO Inferred from Sequence Orthology more info
involved_in zinc ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within zinc ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: calcium/manganese antiporter SLC30A10

Names: zinc transporter 10; znT-10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033286.2 → NP_001028458.1 calcium/manganese antiporter SLC30A10

See identical proteins and their annotated locations for NP_001028458.1

Status: VALIDATED

Source sequence(s)

AC131980, AK136932, BB665136

Consensus CDS

CCDS15599.1

UniProtKB/Swiss-Prot

Q32NY2, Q3UVU3

Related

ENSMUSP00000053181.7, ENSMUST00000061093.7

Conserved Domains (2) summary

COG1230
Location:10 → 376

CzcD; Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]

pfam01545
Location:20 → 299

Cation_efflux; Cation efflux family