U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zfp2 zinc finger protein 2 [ Mus musculus (house mouse) ]

Gene ID: 22678, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Zfp2provided by MGI
Official Full Name
zinc finger protein 2provided by MGI
Primary source
MGI:MGI:99167
See related
Ensembl:ENSMUSG00000049321 AllianceGenome:MGI:99167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKR2; Fnp-2; Zfp-2; mkr-2; mszf87; 9930007F06Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including nervous system; urinary system; and vertebral pre-cartilage condensation. Orthologous to human ZFP2 (ZFP2 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 2.3), whole brain E14.5 (RPKM 2.2) and 20 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
11 B1.3; 11 30.94 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50788092..50807043, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50897265..50916216, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6979 Neighboring gene glutamate receptor, metabotropic 6 Neighboring gene zinc finger protein 454 Neighboring gene STARR-seq mESC enhancer starr_29409 Neighboring gene zinc finger protein 354B Neighboring gene RIKEN cDNA 4933414I15 gene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The primary structure of the murine multifinger gene mKr2 and its specific expression in developing and adult neurons. Chowdhury K, et al. EMBO J, 1988 May. PMID 3409867, Free PMC Article
  2. A multigene family encoding several "finger" structures is present and differentially active in mammalian genomes. Chowdhury K, et al. Cell, 1987 Mar 13. PMID 3815523
  3. Zinc finger protein gene complexes on mouse chromosomes 8 and 11. Nadeau JH, et al. Genomics, 1990 Nov. PMID 1981050
  4. ILDR2 stabilization is regulated by its interaction with GRP78. Watanabe K, et al. Sci Rep, 2021 Apr 16. PMID 33863978, Free PMC Article
  5. Zinc finger protein genes in the mouse genome. Ashworth A, et al. Mamm Genome, 1991. PMID 1797234

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC107189

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
zinc finger protein ZFP2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001044697.2 → NP_001038162.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001038162.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AK141471, BC052029, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Related
    ENSMUSP00000112079.2, ENSMUST00000116378.8
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001044698.2 → NP_001038163.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001038163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AK141471, BC052029, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. NM_001044700.2 → NP_001038165.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001038165.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    BC052029, BC089506, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001294323.1 → NP_001281252.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_001281252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AL627215, BC052029, BY107004, CJ044064
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Related
    ENSMUSP00000104757.2, ENSMUST00000109129.8
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_178447.3 → NP_848542.1  zinc finger protein ZFP2

    See identical proteins and their annotated locations for NP_848542.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longest transcript. Variants 2, 3, 4, 6 and 7 encode the same protein.
    Source sequence(s)
    AL627215, BC052029, BY107004
    Consensus CDS
    CCDS36148.1
    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Related
    ENSMUSP00000104756.2, ENSMUST00000109128.8
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    50788092..50807043 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314506.2 → XP_017169995.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. XM_030245935.2 → XP_030101795.1  zinc finger protein ZFP2 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:131 → 484
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:417 → 437
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_030245940.1 → XP_030101800.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_036156640.1 → XP_036012533.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. XM_036156638.1 → XP_036012531.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_036156639.1 → XP_036012532.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_030245936.1 → XP_030101796.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_036156637.1 → XP_036012530.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  9. XM_030245938.1 → XP_030101798.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  10. XM_030245941.1 → XP_030101801.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  11. XM_030245937.2 → XP_030101797.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

  12. XM_030245939.2 → XP_030101799.1  zinc finger protein ZFP2 isoform X2

    UniProtKB/Swiss-Prot
    P08043, Q3V280, Q8R012
    Conserved Domains (2) summary
    COG5048
    Location:96 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 402
    ZF_C2H2; C2H2 Zn finger [structural motif]

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001044699.1: Suppressed sequence

    Description
    NM_001044699.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.

  2. NM_009550.1: Suppressed sequence

    Description
    NM_009550.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P08043.2 GenPept UniProtKB/Swiss-Prot:P08043

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous