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Zbtb14 zinc finger and BTB domain containing 14 [ Mus musculus (house mouse) ]

Gene ID: 22666, updated on 5-Mar-2024

Summary

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Official Symbol
Zbtb14provided by MGI
Official Full Name
zinc finger and BTB domain containing 14provided by MGI
Primary source
MGI:MGI:1195345
See related
Ensembl:ENSMUSG00000049672 AllianceGenome:MGI:1195345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ZF5; Zfp161; b2b1982Clo
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Acts upstream of or within heart development and kidney development. Predicted to be located in aggresome; cytosol; and nucleolus. Predicted to be active in nucleoplasm. Is expressed in ureter. Orthologous to human ZBTB14 (zinc finger and BTB domain containing 14). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.3), CNS E14 (RPKM 5.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E1.3; 17 40.42 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (69690170..69697747)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (69383175..69390752)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 3 Neighboring gene RIKEN cDNA 2410021H03 gene Neighboring gene STARR-seq mESC enhancer starr_43121 Neighboring gene STARR-seq mESC enhancer starr_43123 Neighboring gene STARR-seq mESC enhancer starr_43125 Neighboring gene predicted gene, 53973 Neighboring gene RIKEN cDNA C030034I22 gene Neighboring gene STARR-seq mESC enhancer starr_43127 Neighboring gene RIKEN cDNA A730049N16 gene Neighboring gene A kinase anchor inhibitor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Genomic cloning and characterization of the mouse POZ/zinc-finger protein ZF5. Yokoro K, et al. Biochem Biophys Res Commun, 1998 May 29. PMID 9618270
  2. Analysis of the consensus binding sequence and the DNA-binding domain of ZF5. Obata T, et al. Biochem Biophys Res Commun, 1999 Feb 16. PMID 10049742
  3. Expression cloning and intracellular localization of a human ZF5 homologue. Sugiura K, et al. Biochim Biophys Acta, 1997 May 2. PMID 9177479
  4. Transcriptional repressor ZF5 identifies a new conserved domain in zinc finger proteins. Numoto M, et al. Nucleic Acids Res, 1993 Aug 11. PMID 8367294, Free PMC Article
  5. ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Kim W, et al. Nat Commun, 2019 Nov 22. PMID 31757956, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac septum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within coronary vasculature development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within heart valve development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in aggresome ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 14
Names
zfp-161
zinc finger protein 161
zinc finger protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356282.1 → NP_001343211.1  zinc finger and BTB domain-containing protein 14

    Status: VALIDATED

    Source sequence(s)
    AC122487, AK082051, AK136762, AK145517, BC052017, BY070865
    Consensus CDS
    CCDS37682.1
    UniProtKB/Swiss-Prot
    Q08376
    UniProtKB/TrEMBL
    Q544H8
    Related
    ENSMUSP00000054897.8, ENSMUST00000062369.14
    Conserved Domains (4) summary
    COG5189
    Location:303 → 383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307 → 327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18204
    Location:18 → 131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
    pfam13465
    Location:319 → 344
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001356283.1 → NP_001343212.1  zinc finger and BTB domain-containing protein 14

    Status: VALIDATED

    Source sequence(s)
    AC122487
    Consensus CDS
    CCDS37682.1
    UniProtKB/Swiss-Prot
    Q08376
    UniProtKB/TrEMBL
    Q544H8
    Related
    ENSMUSP00000108294.2, ENSMUST00000112674.8
    Conserved Domains (4) summary
    COG5189
    Location:303 → 383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307 → 327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18204
    Location:18 → 131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
    pfam13465
    Location:319 → 344
    zf-H2C2_2; Zinc-finger double domain

  3. NM_009547.3 → NP_033573.1  zinc finger and BTB domain-containing protein 14

    See identical proteins and their annotated locations for NP_033573.1

    Status: VALIDATED

    Source sequence(s)
    AK082051, AK136762, BC052017, CB247149
    Consensus CDS
    CCDS37682.1
    UniProtKB/Swiss-Prot
    Q08376
    UniProtKB/TrEMBL
    Q544H8
    Related
    ENSMUSP00000108296.3, ENSMUST00000112676.4
    Conserved Domains (4) summary
    COG5189
    Location:303 → 383
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:307 → 327
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18204
    Location:18 → 131
    BTB_POZ_ZBTB14; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14)
    pfam13465
    Location:319 → 344
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    69690170..69697747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08376.1 GenPept UniProtKB/Swiss-Prot:Q08376

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