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Atf6 activating transcription factor 6 [ Mus musculus (house mouse) ]

Gene ID: 226641, updated on 16-Apr-2024

Summary

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Official Symbol
Atf6provided by MGI
Official Full Name
activating transcription factor 6provided by MGI
Primary source
MGI:MGI:1926157
See related
Ensembl:ENSMUSG00000026663 AllianceGenome:MGI:1926157
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ESTM49; Atf6alpha; 9630036G24; 9130025P16Rik
Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; protein heterodimerization activity; and ubiquitin protein ligase binding activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including embryo mesenchyme; eye; liver; long bone; and tooth. Human ortholog(s) of this gene implicated in achromatopsia 7. Orthologous to human ATF6 (activating transcription factor 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 10.2), genital fat pad adult (RPKM 8.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H3; 1 76.96 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170532026..170696414, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170704457..170868585, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02995 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene olfactomedin-like 2B Neighboring gene predicted gene, 23523 Neighboring gene predicted gene, 25235 Neighboring gene STARR-positive B cell enhancer ABC_E4381 Neighboring gene STARR-positive B cell enhancer ABC_E7774 Neighboring gene STARR-positive B cell enhancer ABC_E7775 Neighboring gene STARR-positive B cell enhancer ABC_E5842 Neighboring gene predicted gene, 29733 Neighboring gene STARR-seq mESC enhancer starr_02996 Neighboring gene predicted gene 9929 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene dual specificity phosphatase 12 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene Fc receptor-like B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b(+) macrophage subpopulations and aggravates lung fibrosis. Mekhael O, et al. Immunol Cell Biol, 2023 May. PMID 36862017
  2. Beneficial effects of neuronal ATF6 activation in permanent ischemic stroke. Li X, et al. Front Cell Neurosci, 2022. PMID 36313623, Free PMC Article
  3. ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance. Ge L, et al. Front Immunol, 2022. PMID 36300114, Free PMC Article
  4. ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice. Yu R, et al. Andrologia, 2022 Apr. PMID 34904262
  5. The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts. Stauffer WT, et al. Int J Mol Sci, 2020 Feb 18. PMID 32085622, Free PMC Article

See all (169) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATF6 protects against protein misfolding during cardiac hypertrophy.
    Title: ATF6 protects against protein misfolding during cardiac hypertrophy.
  2. Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6alpha and ATF6beta.
    Title: Partial limitation of cellular functions and compensatory modulation of unfolded protein response pathways caused by double-knockout of ATF6α and ATF6β.
  3. Activating transcription factor (ATF) 6 upregulates cystathionine beta synthetase (CBS) expression and hydrogen sulfide (H2S) synthesis to ameliorate liver metabolic damage.
    Title: Activating transcription factor (ATF) 6 upregulates cystathionine β synthetase (CBS) expression and hydrogen sulfide (H(2)S) synthesis to ameliorate liver metabolic damage.
  4. Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b[+] macrophage subpopulations and aggravates lung fibrosis.
    Title: Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b(+) macrophage subpopulations and aggravates lung fibrosis.
  5. [Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells].
    Title: [Crosstalk between activating transcription factor 6 and the inositol-requiring enzyme 1-X-box binding protein 1 pathway in oxygen-glucose deprivation/reoxygenation-injured HT22 cells].
  6. ATF6alpha contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance.
    Title: ATF6α contributes to rheumatoid arthritis by inducing inflammatory cytokine production and apoptosis resistance.
  7. Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.
    Title: Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.
  8. MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6.
    Title: MiR-195-5p represses inflammation, apoptosis, oxidative stress, and endoplasmic reticulum stress in sepsis-induced myocardial injury by targeting activating transcription factor 6.
  9. A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver.
    Title: A permissive epigenetic landscape facilitates distinct transcriptional signatures of activating transcription factor 6 in the liver.
  10. ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice.
    Title: ATF6 deficiency damages the development of spermatogenesis in male Atf6 knockout mice.
Submit: New GeneRIF Correction See all GeneRIFs (78)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ATF6-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to unfolded protein IEA
Inferred from Electronic Annotation
more info
  
involved_in visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum NAS
Non-traceable Author Statement
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
cyclic AMP-dependent transcription factor ATF-6 alpha
Names
ATF6-alpha
activating transcription factor 6 alpha
cAMP-dependent transcription factor ATF-6 alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081304.1 → NP_001074773.1  cyclic AMP-dependent transcription factor ATF-6 alpha

    See identical proteins and their annotated locations for NP_001074773.1

    Status: VALIDATED

    Source sequence(s)
    AC113490, AC125021
    Consensus CDS
    CCDS56653.1
    UniProtKB/Swiss-Prot
    B2RU98, F6VAN0, Q8BZ84
    UniProtKB/TrEMBL
    Q811K9
    Related
    ENSMUSP00000027974.6, ENSMUST00000027974.7
    Conserved Domains (2) summary
    cd14700
    Location:296 → 347
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:223 → 298
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    170532026..170696414 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030253420.2 → XP_030109280.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X1

    UniProtKB/Swiss-Prot
    B2RU98, F6VAN0, Q8BZ84
    UniProtKB/TrEMBL
    Q811K9
    Conserved Domains (2) summary
    cd14700
    Location:296 → 347
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:223 → 298
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  2. XM_011238796.4 → XP_011237098.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X2

    UniProtKB/TrEMBL
    Q811K9
    Conserved Domains (2) summary
    cd14700
    Location:296 → 347
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:223 → 298
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II

  3. XM_006496792.5 → XP_006496855.1  cyclic AMP-dependent transcription factor ATF-6 alpha isoform X3

    UniProtKB/TrEMBL
    Q811K9
    Conserved Domains (2) summary
    cd14700
    Location:281 → 332
    bZIP_ATF6; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-6 (ATF-6) and similar proteins: a DNA-binding and dimerization domain
    pfam05817
    Location:208 → 283
    Ribophorin_II; Oligosaccharyltransferase subunit Ribophorin II
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F6VAN0.2 GenPept UniProtKB/Swiss-Prot:F6VAN0

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