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Tiprl TIP41, TOR signalling pathway regulator-like (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 226591, updated on 11-Apr-2024

Summary

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Official Symbol
Tiprlprovided by MGI
Official Full Name
TIP41, TOR signalling pathway regulator-like (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1915087
See related
Ensembl:ENSMUSG00000040843 AllianceGenome:MGI:1915087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
1810011K17Rik
Summary
Predicted to be involved in DNA damage checkpoint signaling; TOR signaling; and negative regulation of phosphoprotein phosphatase activity. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and immune system. Orthologous to human TIPRL (TOR signaling pathway regulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 10.8), CNS E14 (RPKM 8.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.2; 1 72.55 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (165039855..165110228, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (165212286..165282659, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene T-box 19 Neighboring gene STARR-seq mESC enhancer starr_02894 Neighboring gene SFT2 domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_02896 Neighboring gene STARR-seq mESC enhancer starr_02898 Neighboring gene G protein-coupled receptor 161 Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene STARR-seq mESC enhancer starr_02900 Neighboring gene STARR-positive B cell enhancer ABC_E2016 Neighboring gene STARR-positive B cell enhancer ABC_E119 Neighboring gene predicted gene, 24637 Neighboring gene mitochondrial pyruvate carrier 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Methylation-regulated decommissioning of multimeric PP2A complexes. Wu CG, et al. Nat Commun, 2017 Dec 22. PMID 29273778, Free PMC Article
  2. TIPRL Inhibits Protein Phosphatase 4 Activity and Promotes H2AX Phosphorylation in the DNA Damage Response. Rosales KR, et al. PLoS One, 2015. PMID 26717153, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells. Zhang S, et al. Sci Data, 2018 Nov 20. PMID 30457570, Free PMC Article
  5. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
TIP41-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357410.1 → NP_001344339.1  TIP41-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154142
    Conserved Domains (1) summary
    pfam04176
    Location:38 → 206
    TIP41; TIP41-like family

  2. NM_001357411.1 → NP_001344340.1  TIP41-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154142
    Conserved Domains (1) summary
    pfam04176
    Location:9 → 177
    TIP41; TIP41-like family

  3. NM_145513.4 → NP_663488.1  TIP41-like protein isoform 1

    See identical proteins and their annotated locations for NP_663488.1

    Status: VALIDATED

    Source sequence(s)
    AK049784, CF531065
    Consensus CDS
    CCDS15441.1
    UniProtKB/Swiss-Prot
    Q8BH58
    Related
    ENSMUSP00000037514.6, ENSMUST00000043235.8
    Conserved Domains (1) summary
    pfam04176
    Location:50 → 218
    TIP41; TIP41-like family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    165039855..165110228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011238792.3 → XP_011237094.1  TIP41-like protein isoform X1

    See identical proteins and their annotated locations for XP_011237094.1

    Conserved Domains (1) summary
    pfam04176
    Location:9 → 177
    TIP41; TIP41-like family

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_180963.1: Suppressed sequence

    Description
    NM_180963.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BH58.1 GenPept UniProtKB/Swiss-Prot:Q8BH58

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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