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Zfp13 zinc finger protein 13 [ Mus musculus (house mouse) ]

Gene ID: 22654, updated on 5-Mar-2024

Summary

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Official Symbol
Zfp13provided by MGI
Official Full Name
zinc finger protein 13provided by MGI
Primary source
MGI:MGI:99159
See related
Ensembl:ENSMUSG00000062012 AllianceGenome:MGI:99159
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Krox-8; Zfp-13
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including early conceptus; eye; genitourinary system; hemolymphoid system gland; and liver. Orthologous to human ZNF205 (zinc finger protein 205). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 18.2), ovary adult (RPKM 12.7) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Zfp13 in Genome Data Viewer
Location:
17 A3.3; 17 11.72 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (23788820..23818729, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (23569846..23599755, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330415G19 gene Neighboring gene caspase 16, apoptosis-related cysteine peptidase Neighboring gene zinc finger protein 213 Neighboring gene STARR-positive B cell enhancer ABC_E9944 Neighboring gene STARR-seq mESC enhancer starr_42052 Neighboring gene STARR-seq mESC enhancer starr_42053 Neighboring gene STARR-seq mESC enhancer starr_42054 Neighboring gene zinc finger and SCAN domain containing 10 Neighboring gene calcium binding protein 39-like pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism. Iida R, et al. Mol Cell Biol, 2010 May. PMID 20231359, Free PMC Article
  2. Characterization of a mouse multigene family that encodes zinc finger structures. Chavrier P, et al. Mol Cell Biol, 1988 Mar. PMID 2452975, Free PMC Article
  3. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  4. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  5. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that Rhit acts as a repressor in the heat-induced and age-dependent transcriptional regulation of the (S) isoform of Mpv17-like protein.
    Title: A novel transcriptional repressor, Rhit, is involved in heat-inducible and age-dependent expression of Mpv17-like protein, a participant in reactive oxygen species metabolism.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of hydrogen peroxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcriptional repressor Rhit
Names
zinc finger protein Krox-8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356268.2 → NP_001343197.1  transcriptional repressor Rhit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154766
    Consensus CDS
    CCDS89003.1
    UniProtKB/Swiss-Prot
    D7F2B3, P10754, Q80WS0, Q8CDD0
    Related
    ENSMUSP00000111178.4, ENSMUST00000115516.11
    Conserved Domains (4) summary
    COG5048
    Location:326 → 486
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:380 → 400
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:123 → 154
    KRAB; KRAB box
    pfam13465
    Location:280 → 305
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001414203.1 → NP_001401132.1  transcriptional repressor Rhit isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154766

  3. NM_001414204.1 → NP_001401133.1  transcriptional repressor Rhit isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154766

  4. NM_001414205.1 → NP_001401134.1  transcriptional repressor Rhit isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154766

  5. NM_001414207.1 → NP_001401136.1  transcriptional repressor Rhit isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154766

  6. NM_001414208.1 → NP_001401137.1  transcriptional repressor Rhit isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC154766

  7. NM_001414209.1 → NP_001401138.1  transcriptional repressor Rhit isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC154766

  8. NM_001414210.1 → NP_001401139.1  transcriptional repressor Rhit isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC154766

  9. NM_001414211.1 → NP_001401140.1  transcriptional repressor Rhit isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC154766

  10. NM_001414212.1 → NP_001401141.1  transcriptional repressor Rhit isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154766
    UniProtKB/Swiss-Prot
    D7F2B3, P10754, Q80WS0, Q8CDD0

  11. NM_011747.4 → NP_035877.1  transcriptional repressor Rhit isoform 1

    See identical proteins and their annotated locations for NP_035877.1

    Status: VALIDATED

    Source sequence(s)
    AC154766
    Consensus CDS
    CCDS28450.1
    UniProtKB/Swiss-Prot
    P10754
    Related
    ENSMUSP00000054595.5, ENSMUST00000057029.5
    Conserved Domains (4) summary
    COG5048
    Location:319 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:373 → 393
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:116 → 147
    KRAB; KRAB box
    pfam13465
    Location:273 → 298
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_182255.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154766

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    23788820..23818729 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246423.3 → XP_011244725.1  transcriptional repressor Rhit isoform X2

    See identical proteins and their annotated locations for XP_011244725.1

    Conserved Domains (4) summary
    smart00349
    Location:117 → 172
    KRAB; krueppel associated box
    COG5048
    Location:353 → 513
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:407 → 427
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307 → 332
    zf-H2C2_2; Zinc-finger double domain

  2. XM_030249750.1 → XP_030105610.1  transcriptional repressor Rhit isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:336 → 496
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:390 → 410
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:116 → 147
    KRAB; KRAB box
    pfam13465
    Location:290 → 315
    zf-H2C2_2; Zinc-finger double domain

  3. XM_011246421.3 → XP_011244723.1  transcriptional repressor Rhit isoform X1

    See identical proteins and their annotated locations for XP_011244723.1

    Conserved Domains (4) summary
    smart00349
    Location:124 → 179
    KRAB; krueppel associated box
    COG5048
    Location:360 → 520
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:414 → 434
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:314 → 339
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10754.2 GenPept UniProtKB/Swiss-Prot:P10754

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