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Rasal2 RAS protein activator like 2 [ Mus musculus (house mouse) ]

Gene ID: 226525, updated on 3-Apr-2024

Summary

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Official Symbol
Rasal2provided by MGI
Official Full Name
RAS protein activator like 2provided by MGI
Primary source
MGI:MGI:2443881
See related
Ensembl:ENSMUSG00000070565 AllianceGenome:MGI:2443881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6530401P13; A330066M24Rik
Summary
Is expressed in central nervous system; dorsal root ganglion; nose; and turbinate bone primordium. Orthologous to human RASAL2 (RAS protein activator like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 6.2), CNS E14 (RPKM 5.6) and 26 other tissues See more
Orthologs
human all
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Genomic context

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See Rasal2 in Genome Data Viewer
Location:
1 H1; 1 67.97 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (156962759..157240170, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (157135183..157412595, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene testis expressed 35 Neighboring gene predicted gene, 30694 Neighboring gene predicted gene, 51654 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02764 Neighboring gene ash2 (absent, small, or homeotic)-like pseudogene Neighboring gene RIKEN cDNA 2810025M15 gene Neighboring gene STARR-positive B cell enhancer ABC_E5829 Neighboring gene GABA(A) receptor-associated protein-like 2 pseudogene 1_1522.1 Neighboring gene STARR-seq mESC enhancer starr_02765 Neighboring gene STARR-seq mESC enhancer starr_02769 Neighboring gene STARR-seq mESC enhancer starr_02770 Neighboring gene crystallin zeta like 2 Neighboring gene predicted gene, 57801

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension. Hu S, et al. Bioengineered, 2022 Feb. PMID 35044284, Free PMC Article
  2. RASAL2 promotes lung cancer metastasis through epithelial-mesenchymal transition. Li N, et al. Biochem Biophys Res Commun, 2014 Dec 12. PMID 25446096
  3. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor. McLaughlin SK, et al. Cancer Cell, 2013 Sep 9. PMID 24029233, Free PMC Article
  4. Silencing of lncRNA SNHG20 delays the progression of nonalcoholic fatty liver disease to hepatocellular carcinoma via regulating liver Kupffer cells polarization. Wang B, et al. IUBMB Life, 2019 Dec. PMID 31408278
  5. Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders. Zhu X, et al. Mol Metab, 2017 Jun. PMID 28580280, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension.
    Title: RAS protein activator like 2 promotes the proliferation and migration of pulmonary artery smooth muscle cell through AKT/mammalian target of Rapamycin complex 1 pathway in pulmonary hypertension.
  2. Rasal2 deficiency leads to impaired adipogenesis in vivo and in vitro. Rasal2 deficiency resulted in increased activity of Ras and ERK in preadipocytes.
    Title: Rasal2 deficiency reduces adipogenesis and occurrence of obesity-related disorders.
  3. the down-regulation of RASAL2 promotes metastatic progression of lung adenocarcinoma
    Title: RASAL2 promotes lung cancer metastasis through epithelial-mesenchymal transition.
  4. The RasGAP gene, RASAL2, is a tumor and metastasis suppressor
    Title: The RasGAP gene, RASAL2, is a tumor and metastasis suppressor.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1) 
  • Gene trapped (1) 
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in adipose tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of protein activation cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to dietary excess IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to glucose IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
ras GTPase-activating protein nGAP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401202.1 → NP_001388131.1  ras GTPase-activating protein nGAP isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC119220, AC119897, AC138382
    Related
    ENSMUSP00000114964.2, ENSMUST00000132699.8

  2. NM_177644.6 → NP_808312.3  ras GTPase-activating protein nGAP isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC119220, AC119897, AC138382
    Consensus CDS
    CCDS48408.1
    UniProtKB/TrEMBL
    E9PW37, Q0VAV5
    Related
    ENSMUSP00000077423.7, ENSMUST00000078308.13
    Conserved Domains (6) summary
    cd04013
    Location:306 → 445
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:436 → 766
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    smart00323
    Location:429 → 767
    RasGAP; GTPase-activator protein for Ras-like GTPases
    pfam12004
    Location:756 → 1248
    DUF3498; Domain of unknown function (DUF3498)
    cl02488
    Location:1110 → 1258
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl17171
    Location:181 → 364
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    156962759..157240170 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496751.3 → XP_006496814.1  ras GTPase-activating protein nGAP isoform X2

    UniProtKB/TrEMBL
    D3YUS5
    Conserved Domains (4) summary
    cd04013
    Location:306 → 445
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:436 → 759
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:749 → 1225
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:181 → 364
    PH-like; Pleckstrin homology-like domain

  2. XM_006496750.3 → XP_006496813.1  ras GTPase-activating protein nGAP isoform X1

    UniProtKB/TrEMBL
    Q0VAV5
    Conserved Domains (4) summary
    cd04013
    Location:306 → 445
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:436 → 766
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:756 → 1232
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:181 → 364
    PH-like; Pleckstrin homology-like domain

  3. XM_036164040.1 → XP_036019933.1  ras GTPase-activating protein nGAP isoform X8

    UniProtKB/TrEMBL
    D3YUS5
    Conserved Domains (4) summary
    cd04013
    Location:159 → 298
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:289 → 612
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:602 → 1078
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:34 → 217
    PH-like; Pleckstrin homology-like domain

  4. XM_006496755.4 → XP_006496818.1  ras GTPase-activating protein nGAP isoform X6

    UniProtKB/TrEMBL
    Q0VAV5
    Conserved Domains (4) summary
    cd04013
    Location:159 → 298
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:289 → 619
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:609 → 1085
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:34 → 217
    PH-like; Pleckstrin homology-like domain

  5. XM_006496753.5 → XP_006496816.1  ras GTPase-activating protein nGAP isoform X4

    UniProtKB/TrEMBL
    Q0VAV5
    Conserved Domains (4) summary
    cd04013
    Location:242 → 381
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:372 → 702
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:692 → 1168
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:117 → 300
    PH-like; Pleckstrin homology-like domain

  6. XM_006496756.5 → XP_006496819.1  ras GTPase-activating protein nGAP isoform X9

    UniProtKB/TrEMBL
    Q0VAV5
    Conserved Domains (4) summary
    cd04013
    Location:131 → 270
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:261 → 591
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:581 → 1057
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:6 → 189
    PH-like; Pleckstrin homology-like domain

  7. XM_006496754.4 → XP_006496817.1  ras GTPase-activating protein nGAP isoform X5

    UniProtKB/TrEMBL
    Q0VAV5
    Conserved Domains (4) summary
    cd04013
    Location:178 → 317
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:308 → 638
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:628 → 1104
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:53 → 236
    PH-like; Pleckstrin homology-like domain

  8. XM_036164037.1 → XP_036019930.1  ras GTPase-activating protein nGAP isoform X7

    UniProtKB/TrEMBL
    D3YUS5
    Conserved Domains (4) summary
    cd04013
    Location:178 → 317
    C2_SynGAP_like; C2 domain present in Ras GTPase activating protein (GAP) family
    cd05136
    Location:308 → 631
    RasGAP_DAB2IP; Ras-GTPase Activating Domain of DAB2IP and similar proteins
    pfam12004
    Location:621 → 1097
    DUF3498; Domain of unknown function (DUF3498)
    cl17171
    Location:53 → 236
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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