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Mkrn3 makorin, ring finger protein, 3 [ Mus musculus (house mouse) ]

Gene ID: 22652, updated on 21-Apr-2024

Summary

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Official Symbol
Mkrn3provided by MGI
Official Full Name
makorin, ring finger protein, 3provided by MGI
Primary source
MGI:MGI:2181178
See related
Ensembl:ENSMUSG00000070527 AllianceGenome:MGI:2181178
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfp127; D7H15S9-1
Summary
Predicted to enable identical protein binding activity and ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Is expressed in gut; nervous system; and sensory organ. Used to study endocrine system disease. Human ortholog(s) of this gene implicated in central precocious puberty 2. Orthologous to human MKRN3 (makorin ring finger protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human all
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Genomic context

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Location:
7 C; 7 34.37 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (62067341..62069901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (62417593..62420153, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32061 Neighboring gene necdin, MAGE family member Neighboring gene MAGE family member L2 Neighboring gene STARR-seq mESC enhancer starr_18999 Neighboring gene paternally expressed 12 Neighboring gene ATP synthase, H+ transporting, mitochondrial F0 complex, subunit G, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Methylation status of hypothalamic Mkrn3 promoter across puberty. Fanis P, et al. Front Endocrinol (Lausanne), 2022. PMID 36714607, Free PMC Article
  2. Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice. Roberts SA, et al. Endocrinology, 2022 Oct 11. PMID 35974456, Free PMC Article
  3. MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity. Naulé L, et al. JCI Insight, 2023 Apr 24. PMID 37092553, Free PMC Article
  4. Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4. Kwon YW, et al. BMB Rep, 2018 May. PMID 29335068, Free PMC Article
  5. Mkrn3 functions as a novel ubiquitin E3 ligase to inhibit Nptx1 during puberty initiation. Liu H, et al. Oncotarget, 2017 Oct 17. PMID 29156706, Free PMC Article

See all (44) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG.
    Title: Mouse Testicular Mkrn3 Expression Is Primarily Interstitial, Increases Peripubertally, and Is Responsive to LH/hCG.
  2. MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.
    Title: MKRN3 inhibits puberty onset via interaction with IGF2BP1 and regulation of hypothalamic plasticity.
  3. Methylation status of hypothalamic Mkrn3 promoter across puberty.
    Title: Methylation status of hypothalamic Mkrn3 promoter across puberty.
  4. Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice.
    Title: Hypothalamic Overexpression of Makorin Ring Finger Protein 3 Results in Delayed Puberty in Female Mice.
  5. E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.
    Title: E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.
  6. MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.
    Title: MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.
  7. Zfp127 is a novel regulator of Oct4, and may become a potent target to improve cellular reprogramming.
    Title: Imprinted gene Zinc finger protein 127 is a novel regulator of master pluripotency transcription factor, Oct4.
  8. Mkrn3, encoding a RING zinc-finger protein, is imprinted, with preferential expression from the paternal allele.
    Title: Imprinting of a RING zinc-finger encoding gene in the mouse chromosome region homologous to the Prader-Willi syndrome genetic region.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase makorin-3
Names
RING-type E3 ubiquitin transferase makorin-3
zinc finger protein 127
NP_035876.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011746.3 → NP_035876.2  probable E3 ubiquitin-protein ligase makorin-3

    See identical proteins and their annotated locations for NP_035876.2

    Status: VALIDATED

    Source sequence(s)
    AC156555
    Consensus CDS
    CCDS21327.1
    UniProtKB/Swiss-Prot
    Q3UY92, Q60764, Q7TQE4
    Related
    ENSMUSP00000091898.4, ENSMUST00000094340.4
    Conserved Domains (3) summary
    smart00356
    Location:92 → 118
    ZnF_C3H1; zinc finger
    cd00162
    Location:347 → 401
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    pfam15815
    Location:467 → 542
    MKRN1_C; E3 ubiquitin-protein ligase makorin-1, C-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    62067341..62069901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q60764.2 GenPept UniProtKB/Swiss-Prot:Q60764

Gene LinkOut

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