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Zfp281 zinc finger protein 281 [ Mus musculus (house mouse) ]

Gene ID: 226442, updated on 21-Apr-2024

Summary

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Official Symbol
Zfp281provided by MGI
Official Full Name
zinc finger protein 281provided by MGI
Primary source
MGI:MGI:3029290
See related
Ensembl:ENSMUSG00000041483 AllianceGenome:MGI:3029290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Znf281
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in embryonic body morphogenesis and stem cell differentiation. Predicted to be located in nucleoplasm. Is expressed in several structures, including branchial arch; extraembryonic component; forelimb bud; genitourinary system; and limb. Orthologous to human ZNF281 (zinc finger protein 281). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.0), CNS E14 (RPKM 4.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 59.93 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (136552639..136558129)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (136624901..136630391)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 9230116N13 gene Neighboring gene STARR-seq mESC enhancer starr_02406 Neighboring gene DEAD box helicase 59 Neighboring gene STARR-positive B cell enhancer ABC_E993 Neighboring gene kinesin family member 14 Neighboring gene predicted gene 29485 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138447476-138447776 Neighboring gene STARR-seq mESC enhancer starr_02411 Neighboring gene STARR-seq mESC enhancer starr_02413 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:138476081-138476290 Neighboring gene STARR-positive B cell enhancer ABC_E145 Neighboring gene STARR-seq mESC enhancer starr_02418 Neighboring gene STARR-positive B cell enhancer ABC_E5807 Neighboring gene STARR-positive B cell enhancer mm9_chr1:138521286-138521587 Neighboring gene predicted gene, 34056 Neighboring gene STARR-seq mESC enhancer starr_02427 Neighboring gene predicted gene, 41958 Neighboring gene predicted gene, 19705

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency. Huang X, et al. Protein Cell, 2021 Mar. PMID 32812113, Free PMC Article
  2. Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2. Mayer D, et al. EMBO J, 2020 Jan 15. PMID 31782544, Free PMC Article
  3. LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency. Yan P, et al. J Mol Cell Biol, 2021 Aug 4. PMID 33049031, Free PMC Article
  4. ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation. Luo Z, et al. Mol Cell Biol, 2019 Dec 15. PMID 31570506, Free PMC Article
  5. The transcription factor Zfp281 sustains CD4(+) T lymphocyte activation through directly repressing Ctla-4 transcription. Guo J, et al. Cell Mol Immunol, 2020 Dec. PMID 31511645, Free PMC Article

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
    Title: ZFP281 controls transcriptional and epigenetic changes promoting mouse pluripotent state transitions via DNMT3 and TET1.
  2. Zfp281 and Zfp148 control CD4[+] T cell thymic development and TH2 functions.
    Title: Zfp281 and Zfp148 control CD4(+) T cell thymic development and T(H)2 functions.
  3. LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency.
    Title: LncRNA Platr22 promotes super-enhancer activity and stem cell pluripotency.
  4. The transcription factor Zfp281 sustains CD4(+) T lymphocyte activation through directly repressing Ctla-4 transcription.
    Title: The transcription factor Zfp281 sustains CD4(+) T lymphocyte activation through directly repressing Ctla-4 transcription.
  5. ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency.
    Title: ZFP281 recruits polycomb repressive complex 2 to restrict extraembryonic endoderm potential in safeguarding embryonic stem cell pluripotency.
  6. ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
    Title: ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
  7. reveals that cell type-invariant chromatin association of Zfp281 provides an interaction platform for remodeling the cis-regulatory network underlying cellular plasticity
    Title: Zfp281 orchestrates interconversion of pluripotent states by engaging Ehmt1 and Zic2.
  8. Zfp281 is a conserved factor for the maintenance of trophoblast stem cell plasticity.
    Title: Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development.
  9. Authors found that the Kruppel-like transcription factor ZFP281 plays important roles in recruiting MYC to active promoters in mouse embryonic stem cells. At the genome scale, ZFP281 is broadly associated with MYC, and the depletion of ZFP281 significantly reduces the levels of MYC and RNA polymerase II at the ZFP281- and MYC-cobound genes.
    Title: ZFP281 Recruits MYC to Active Promoters in Regulating Transcriptional Initiation and Elongation.
  10. These observations suggest that ZNF281 is a controller of neuronal differentiation that should be evaluated as a prognostic marker in neuroblastoma.
    Title: ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7737, MGC70044

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger protein 281

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160251.1 → NP_001153723.1  zinc finger protein 281

    See identical proteins and their annotated locations for NP_001153723.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AC126606, AV581959, BC062153
    Consensus CDS
    CCDS15327.1
    UniProtKB/Swiss-Prot
    Q3U063, Q4FK52, Q99LI5
    Related
    ENSMUSP00000107677.2, ENSMUST00000112046.2
    Conserved Domains (3) summary
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:258 → 280
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:328 → 353
    zf-H2C2_2; Zinc-finger double domain

  2. NM_177643.4 → NP_808311.1  zinc finger protein 281

    See identical proteins and their annotated locations for NP_808311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
    Source sequence(s)
    AC126606, AK142218, AV581959
    Consensus CDS
    CCDS15327.1
    UniProtKB/Swiss-Prot
    Q3U063, Q4FK52, Q99LI5
    Related
    ENSMUSP00000039003.9, ENSMUST00000047734.15
    Conserved Domains (3) summary
    sd00017
    Location:260 → 280
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:258 → 280
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:328 → 353
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    136552639..136558129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LI5.1 GenPept UniProtKB/Swiss-Prot:Q99LI5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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