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Igfn1 immunoglobulin-like and fibronectin type III domain containing 1 [ Mus musculus (house mouse) ]

Gene ID: 226438, updated on 5-Mar-2024

Summary

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Official Symbol
Igfn1provided by MGI
Official Full Name
immunoglobulin-like and fibronectin type III domain containing 1provided by MGI
Primary source
MGI:MGI:3045352
See related
Ensembl:ENSMUSG00000051985 AllianceGenome:MGI:3045352
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9830123M21Rik
Summary
Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules; retina layer formation; and synapse assembly. Located in Z disc and nucleus. Is expressed in brain. Orthologous to human IGFN1 (immunoglobulin like and fibronectin type III domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 2.9) and frontal lobe adult (RPKM 1.4) See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 59.44 cM
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135880943..135968663, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135953205..136040925, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene troponin T2, cardiac Neighboring gene STARR-seq mESC enhancer starr_02397 Neighboring gene plakophilin 1 Neighboring gene STARR-seq mESC enhancer starr_02398 Neighboring gene STARR-seq mESC enhancer starr_02399 Neighboring gene STARR-positive B cell enhancer ABC_E10039 Neighboring gene STARR-positive B cell enhancer ABC_E4348 Neighboring gene transmembrane protein 9 Neighboring gene calcium channel, voltage-dependent, L type, alpha 1S subunit Neighboring gene achaete-scute family bHLH transcription factor 5 Neighboring gene STARR-seq mESC enhancer starr_02400

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. IGFN1_v1 is required for myoblast fusion and differentiation. Li X, et al. PLoS One, 2017. PMID 28665998, Free PMC Article
  2. Identification of a Z-band associated protein complex involving KY, FLNC and IGFN1. Baker J, et al. Exp Cell Res, 2010 Jul 1. PMID 20206623
  3. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC129490, MGC129491

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in Z disc IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
immunoglobulin-like and fibronectin type III domain-containing protein 1
Names
eEF1A2 binding protein
immunoglobulin-like and fibronectin type 3 domain containing 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177642.3 → NP_808310.2  immunoglobulin-like and fibronectin type III domain-containing protein 1

    See identical proteins and their annotated locations for NP_808310.2

    Status: VALIDATED

    Source sequence(s)
    AC108813, GU290042
    Consensus CDS
    CCDS48379.1
    UniProtKB/Swiss-Prot
    Q3KNY0, Q8BZ74
    Related
    ENSMUSP00000129680.3, ENSMUST00000166193.9
    Conserved Domains (5) summary
    cd00096
    Location:2773 → 2841
    Ig; Immunoglobulin domain
    smart00410
    Location:2154 → 2238
    IG_like; Immunoglobulin like
    cd00063
    Location:2342 → 2434
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:2755 → 2844
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:2563 → 2635
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135880943..135968663 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529442.3 → XP_006529505.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    F6QKE4
    Related
    ENSMUSP00000119230.3, ENSMUST00000124134.3
    Conserved Domains (6) summary
    cd00063
    Location:690 → 782
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:1121 → 1189
    Ig; Immunoglobulin domain
    pfam04147
    Location:130 → 183
    Nop14; Nop14-like family
    pfam07679
    Location:30 → 121
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:168 → 201
    THB; Tri-helix bundle domain
    cl11960
    Location:403 → 486
    Ig; Immunoglobulin domain

  2. XM_017319937.1 → XP_017175426.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd00063
    Location:2185 → 2277
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:2616 → 2684
    Ig; Immunoglobulin domain
    pfam07679
    Location:30 → 121
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:168 → 201
    THB; Tri-helix bundle domain
    cl11960
    Location:1898 → 1981
    Ig; Immunoglobulin domain

  3. XM_017319947.2 → XP_017175436.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X6

    UniProtKB/Swiss-Prot
    Q3KNY0
    Conserved Domains (3) summary
    cd00063
    Location:138 → 230
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:569 → 637
    Ig; Immunoglobulin domain
    cl11960
    Location:360 → 422
    Ig; Immunoglobulin domain

  4. XM_017319938.2 → XP_017175427.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd00063
    Location:2185 → 2277
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:2616 → 2684
    Ig; Immunoglobulin domain
    pfam07679
    Location:30 → 121
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:168 → 201
    THB; Tri-helix bundle domain
    cl11960
    Location:1898 → 1981
    Ig; Immunoglobulin domain

  5. XM_017319940.2 → XP_017175429.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X1

    Conserved Domains (5) summary
    cd00063
    Location:2185 → 2277
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:2616 → 2684
    Ig; Immunoglobulin domain
    pfam07679
    Location:30 → 121
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:168 → 201
    THB; Tri-helix bundle domain
    cl11960
    Location:1898 → 1981
    Ig; Immunoglobulin domain

  6. XM_036163957.1 → XP_036019850.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X3

    Conserved Domains (4) summary
    cd00063
    Location:2041 → 2133
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18362
    Location:24 → 57
    THB; Tri-helix bundle domain
    cd00096
    Location:2454 → 2456
    Ig; Ig strand A [structural motif]
    cl11960
    Location:2454 → 2543
    Ig; Immunoglobulin domain

  7. XM_017319943.2 → XP_017175432.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X2

    Conserved Domains (4) summary
    cd00063
    Location:2144 → 2236
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00096
    Location:2575 → 2643
    Ig; Immunoglobulin domain
    pfam18362
    Location:127 → 160
    THB; Tri-helix bundle domain
    cl11960
    Location:1 → 80
    Ig; Immunoglobulin domain

  8. XM_006529440.3 → XP_006529503.1  immunoglobulin-like and fibronectin type III domain-containing protein 1 isoform X4

    Conserved Domains (3) summary
    pfam07679
    Location:30 → 121
    I-set; Immunoglobulin I-set domain
    pfam18362
    Location:168 → 201
    THB; Tri-helix bundle domain
    cl11960
    Location:1898 → 1981
    Ig; Immunoglobulin domain

RNA

  1. XR_001784087.1 RNA Sequence

  2. XR_001784086.1 RNA Sequence

  3. XR_387162.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3KNY0.3 GenPept UniProtKB/Swiss-Prot:Q3KNY0

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