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Ipo9 importin 9 [ Mus musculus (house mouse) ]

Gene ID: 226432, updated on 21-Apr-2024

Summary

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Official Symbol
Ipo9provided by MGI
Official Full Name
importin 9provided by MGI
Primary source
MGI:MGI:1918944
See related
Ensembl:ENSMUSG00000041879 AllianceGenome:MGI:1918944
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Imp9; Ranbp9; 0710008K06Rik
Summary
Enables histone binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including central nervous system and retina. Orthologous to human IPO9 (importin 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 30.3), limb E14.5 (RPKM 26.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 E4; 1 58.6 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135310050..135358260, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135382312..135430499, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02362 Neighboring gene leiomodin 1 (smooth muscle) Neighboring gene STARR-seq mESC enhancer starr_02364 Neighboring gene shisa family member 4 Neighboring gene STARR-seq mESC enhancer starr_02365 Neighboring gene STARR-positive B cell enhancer ABC_E10038 Neighboring gene neuron navigator 1 Neighboring gene microRNA 1231 Neighboring gene STARR-seq mESC enhancer starr_02370 Neighboring gene STARR-seq mESC enhancer starr_02371 Neighboring gene predicted gene, 32940

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and subcellular distribution of imp13 are regulated in brain development. You P, et al. In Vitro Cell Dev Biol Anim, 2013 May. PMID 23605716, Free PMC Article
  2. The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein. Lin W, et al. J Biol Chem, 2009 Jul 24. PMID 19494118, Free PMC Article
  3. Multiple pathways contribute to nuclear import of core histones. Mühlhäusser P, et al. EMBO Rep, 2001 Aug. PMID 11493596, Free PMC Article
  4. Strain-specific modifier genes governing craniofacial phenotypes. Mukhopadhyay P, et al. Birth Defects Res A Clin Mol Teratol, 2012 Mar. PMID 22371338, Free PMC Article
  5. Active maintenance of nuclear actin by importin 9 supports transcription. Dopie J, et al. Proc Natl Acad Sci U S A, 2012 Feb 28. PMID 22323606, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • mKIAA1192

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone chaperone activity ISO
Inferred from Sequence Orthology
more info
  
enables nuclear import signal receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome localization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein import into nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein import into nucleus ISA
Inferred from Sequence Alignment
more info
 PubMed 
involved_in protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein stabilization ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ribosome biogenesis ISA
Inferred from Sequence Alignment
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
importin-9
Names
Ran binding protein 9
ran-binding protein 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357575.1 → NP_001344504.1  importin-9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016814
    UniProtKB/Swiss-Prot
    Q91YE6, Q924M3, Q924M4
    Conserved Domains (1) summary
    cl27876
    Location:3 → 776
    Cse1; Cse1

  2. NM_001357576.1 → NP_001344505.1  importin-9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC016814
    UniProtKB/Swiss-Prot
    Q91YE6, Q924M3, Q924M4
    Conserved Domains (1) summary
    COG5656
    Location:192 → 749
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

  3. NM_001357577.1 → NP_001344506.1  importin-9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC016814
    UniProtKB/Swiss-Prot
    Q91YE6, Q924M3, Q924M4
    Conserved Domains (1) summary
    COG5656
    Location:192 → 749
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

  4. NM_001357578.1 → NP_001344507.1  importin-9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC016814
    Conserved Domains (1) summary
    cl27876
    Location:61 → 618
    Cse1

  5. NM_153774.1 → NP_722469.1  importin-9 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC016814, BC056469, CD347972
    Consensus CDS
    CCDS35719.1
    UniProtKB/Swiss-Prot
    Q91YE6, Q924M3, Q924M4
    UniProtKB/TrEMBL
    E9QKZ2
    Related
    ENSMUSP00000036093.8, ENSMUST00000041023.14
    Conserved Domains (3) summary
    smart00913
    Location:43 → 117
    IBN_N; Importin-beta N-terminal domain
    COG5656
    Location:22 → 900
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    sd00044
    Location:420 → 459
    HEAT; HEAT repeat [structural motif]

RNA

  1. NR_151727.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC016814, AK161881, BB851521, BC056469, BM947606, CB245332, CD741683

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    135310050..135358260 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163945.1 → XP_036019838.1  importin-9 isoform X1

    UniProtKB/Swiss-Prot
    Q91YE6, Q924M3, Q924M4
    Conserved Domains (1) summary
    COG5657
    Location:34 → 812
    CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]

  2. XM_006529437.2 → XP_006529500.1  importin-9 isoform X2

    See identical proteins and their annotated locations for XP_006529500.1

    UniProtKB/Swiss-Prot
    Q91YE6, Q924M3, Q924M4
    Conserved Domains (1) summary
    COG5656
    Location:192 → 749
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

  3. XM_036163950.1 → XP_036019843.1  importin-9 isoform X3

    Conserved Domains (1) summary
    COG5656
    Location:192 → 749
    SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91YE6.3 GenPept UniProtKB/Swiss-Prot:Q91YE6

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