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Ablim1 actin-binding LIM protein 1 [ Mus musculus (house mouse) ]

Gene ID: 226251, updated on 11-Apr-2024

Summary

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Official Symbol
Ablim1provided by MGI
Official Full Name
actin-binding LIM protein 1provided by MGI
Primary source
MGI:MGI:1194500
See related
Ensembl:ENSMUSG00000025085 AllianceGenome:MGI:1194500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Limab1; mKIAA0059; 2210411C18Rik; 2610209L21Rik; 4833406P10Rik; 9330196J19Rik
Summary
Enables actin binding activity. Acts upstream of or within axon guidance and positive regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and postsynaptic density. Is expressed in several structures, including early conceptus; genitourinary system; lateral plate mesoderm; nervous system; and node. Orthologous to human ABLIM1 (actin binding LIM protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 23.3), heart adult (RPKM 17.9) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 D2; 19 52.09 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (57021165..57303776, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (57032733..57315344, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_46534 Neighboring gene von Willebrand factor A domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_46535 Neighboring gene actin filament associated protein 1-like 2 Neighboring gene predicted gene, 38597 Neighboring gene STARR-positive B cell enhancer ABC_E3255 Neighboring gene STARR-seq mESC enhancer starr_46541 Neighboring gene STARR-positive B cell enhancer ABC_E1531 Neighboring gene STARR-positive B cell enhancer ABC_E4293 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:57205992-57206175 Neighboring gene STARR-seq mESC enhancer starr_46543 Neighboring gene STARR-seq mESC enhancer starr_46545 Neighboring gene STARR-seq mESC enhancer starr_46546 Neighboring gene STARR-positive B cell enhancer ABC_E11042 Neighboring gene STARR-seq mESC enhancer starr_46548 Neighboring gene STARR-positive B cell enhancer ABC_E7676 Neighboring gene RIKEN cDNA 4930449E18 gene Neighboring gene RIKEN cDNA B230217O12 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:57430022-57430395 Neighboring gene predicted gene, 50270 Neighboring gene FHF complex subunit HOOK interacting protein 2A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility. Jin SH, et al. BMB Rep, 2018 Jul. PMID 29921413, Free PMC Article
  2. Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion. Narahara H, et al. J Cell Physiol, 2018 Jan. PMID 29904924
  3. Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein. Lu C, et al. Neuroscience, 2003. PMID 12849746
  4. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. Roof DJ, et al. J Cell Biol, 1997 Aug 11. PMID 9245787, Free PMC Article
  5. Tectorin-beta (Tectb) maps to mouse chromosome 19. Kim HJ, et al. Genomics, 1998 Nov 1. PMID 9799617

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. abLIM1 regulated the localization of tubulin, migration, and fusion in osteoclasts. Thus, these results indicate that abLIM1 negatively controls osteoclast differentiation by regulating cell migration and fusion mediated via actin formation.
    Title: Actin binding LIM 1 (abLIM1) negatively controls osteoclastogenesis by regulating cell migration and fusion.
  2. ABLIM1 is associated with the regulation of preosteoclast motility via the PI3K/Akt/Rac1 pathway during RANKL-mediated osteoclastogenesis.
    Title: Actin-binding LIM protein 1 regulates receptor activator of NF-κB ligand-mediated osteoclast differentiation and motility.
  3. these results make Ablim1 a candidate for controlling aspects of left-right identity and patterning.
    Title: Analysis of the asymmetrically expressed Ablim1 locus reveals existence of a lateral plate Nodal-independent left sided signal and an early, left-right independent role for nodal flow.
  4. AbLIM-L mutant mice exhibit no apparent morphological or functional defects in photoreceptors and inner retinal neurons. Retinofugal projections and synaptic maturation also appear normal; abLIM-M is likely the isoform related to axon guidance.
    Title: Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axon guidance IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
involved_in lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
 PubMed 
is_active_in stress fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in stress fiber ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
actin-binding LIM protein 1
Names
actin-binding LIM protein family member 1
actin-binding double zinc finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001103177.3 → NP_001096647.1  actin-binding LIM protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001096647.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and lacks three alternate in-frame exons inthe 3' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (2, also known as abLIM-m) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC102655, AC161518, AF404775, AW060969, BE994737
    Consensus CDS
    CCDS50479.1
    UniProtKB/TrEMBL
    Q3UP03
    Related
    ENSMUSP00000107172.2, ENSMUST00000111546.8
    Conserved Domains (6) summary
    smart00153
    Location:666 → 701
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:274 → 665
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. NM_001103178.3 → NP_001096648.1  actin-binding LIM protein 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (3, also known as abLIM-s) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC102655, AC161518, AF404776, AK008893, BE994737, BY268130
    Consensus CDS
    CCDS50478.1
    UniProtKB/TrEMBL
    E9Q030, E9Q9D2
    Related
    ENSMUSP00000127818.2, ENSMUST00000104902.9
    Conserved Domains (3) summary
    smart00153
    Location:510 → 545
    VHP; Villin headpiece domain
    pfam16182
    Location:78 → 509
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

  3. NM_001290813.2 → NP_001277742.1  actin-binding LIM protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks four alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC161518, AF404774, BE994737
    UniProtKB/TrEMBL
    B9EIV0
    Related
    ENSMUSP00000107180.2, ENSMUST00000111555.8
    Conserved Domains (6) summary
    smart00153
    Location:695 → 730
    VHP; Villin headpiece domain
    cd09327
    Location:99 → 150
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:155 → 210
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:226 → 277
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:285 → 340
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:349 → 680
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  4. NM_001290815.2 → NP_001277744.1  actin-binding LIM protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and lacks four alternate in-frame exons in the 3' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (5) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC102655, AC161518, AF404775, AW060969, BE994737
    Consensus CDS
    CCDS70964.1
    UniProtKB/TrEMBL
    E9Q9C4
    Related
    ENSMUSP00000096897.3, ENSMUST00000099294.9
    Conserved Domains (6) summary
    smart00153
    Location:619 → 654
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:274 → 618
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  5. NM_001290816.2 → NP_001277745.1  actin-binding LIM protein 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and lacks four alternate in-frame exons and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It initiates translation at an alternate start codon. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC102655, AC161518, AK143907, BE994737
    Consensus CDS
    CCDS70963.1
    UniProtKB/TrEMBL
    E9Q9C7, Q3UP03
    Related
    ENSMUSP00000107169.2, ENSMUST00000111544.8
    Conserved Domains (6) summary
    smart00153
    Location:633 → 668
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:274 → 632
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  6. NM_001347459.1 → NP_001334388.1  actin-binding LIM protein 1 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC102655, AC161518
    Consensus CDS
    CCDS84456.1
    UniProtKB/TrEMBL
    E9Q9D1, E9Q9Q7
    Related
    ENSMUSP00000107154.2, ENSMUST00000111529.8

  7. NM_001362445.1 → NP_001349374.1  actin-binding LIM protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC102655, AC131756, AC161518
    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (6) summary
    smart00153
    Location:618 → 653
    VHP; Villin headpiece domain
    cd09327
    Location:22 → 73
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:78 → 133
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:149 → 200
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:208 → 263
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 617
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  8. NM_001362446.1 → NP_001349375.1  actin-binding LIM protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC102655, AC131756, AC161518
    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (5) summary
    smart00153
    Location:543 → 578
    VHP; Villin headpiece domain
    cd09328
    Location:3 → 58
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:74 → 125
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:133 → 188
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:198 → 542
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  9. NM_178688.4 → NP_848803.3  actin-binding LIM protein 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as abLIM-l).
    Source sequence(s)
    AC102655, AC161518, AF404774, BE994737
    Consensus CDS
    CCDS38027.1
    UniProtKB/Swiss-Prot
    Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
    UniProtKB/TrEMBL
    E9QK41
    Related
    ENSMUSP00000078336.6, ENSMUST00000079360.12
    Conserved Domains (6) summary
    smart00153
    Location:826 → 861
    VHP; Villin headpiece domain
    cd09327
    Location:99 → 150
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:155 → 210
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:226 → 277
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:285 → 340
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:394 → 825
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    57021165..57303776 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250917.1 → XP_030106777.1  actin-binding LIM protein 1 isoform X22

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:632 → 667
    VHP; Villin headpiece domain
    cd09327
    Location:22 → 73
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:78 → 133
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:149 → 200
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:208 → 263
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:272 → 630
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  2. XM_030250916.1 → XP_030106776.1  actin-binding LIM protein 1 isoform X18

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:667 → 702
    VHP; Villin headpiece domain
    cd09327
    Location:22 → 73
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:78 → 133
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:149 → 200
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:208 → 263
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:272 → 665
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  3. XM_030250913.1 → XP_030106773.1  actin-binding LIM protein 1 isoform X9

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:707 → 742
    VHP; Villin headpiece domain
    cd09327
    Location:22 → 73
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:78 → 133
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:149 → 200
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:208 → 263
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:272 → 705
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  4. XM_017318175.3 → XP_017173664.1  actin-binding LIM protein 1 isoform X5

    UniProtKB/Swiss-Prot
    Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
    Conserved Domains (6) summary
    smart00153
    Location:735 → 770
    VHP; Villin headpiece domain
    cd09327
    Location:22 → 73
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:78 → 133
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:149 → 200
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:208 → 263
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:300 → 733
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  5. XM_006527028.5 → XP_006527091.1  actin-binding LIM protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
    Conserved Domains (6) summary
    smart00153
    Location:749 → 784
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 747
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  6. XM_017318172.3 → XP_017173661.1  actin-binding LIM protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
    Conserved Domains (6) summary
    smart00153
    Location:747 → 782
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 745
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  7. XM_006527036.5 → XP_006527099.1  actin-binding LIM protein 1 isoform X11

    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (6) summary
    smart00153
    Location:700 → 735
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 698
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  8. XM_006527034.5 → XP_006527097.1  actin-binding LIM protein 1 isoform X7

    UniProtKB/TrEMBL
    E9Q9C1, E9Q9C4
    Related
    ENSMUSP00000107183.2, ENSMUST00000111558.8
    Conserved Domains (6) summary
    smart00153
    Location:709 → 744
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 707
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  9. XM_006527035.5 → XP_006527098.1  actin-binding LIM protein 1 isoform X10

    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (6) summary
    smart00153
    Location:707 → 742
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 705
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  10. XM_006527033.5 → XP_006527096.1  actin-binding LIM protein 1 isoform X6

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:721 → 756
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 719
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  11. XM_006527040.5 → XP_006527103.1  actin-binding LIM protein 1 isoform X19

    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (6) summary
    smart00153
    Location:660 → 695
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 658
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  12. XM_017318177.3 → XP_017173666.1  actin-binding LIM protein 1 isoform X15

    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (6) summary
    smart00153
    Location:672 → 707
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 670
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  13. XM_006527038.5 → XP_006527101.1  actin-binding LIM protein 1 isoform X14

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:674 → 709
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 672
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  14. XM_006527039.5 → XP_006527102.1  actin-binding LIM protein 1 isoform X16

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:672 → 707
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 670
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  15. XM_030250914.2 → XP_030106774.1  actin-binding LIM protein 1 isoform X12

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:681 → 716
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 679
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  16. XM_006527037.5 → XP_006527100.1  actin-binding LIM protein 1 isoform X13

    UniProtKB/TrEMBL
    E9Q9C0, Q3UP03
    Related
    ENSMUSP00000107184.2, ENSMUST00000111559.8
    Conserved Domains (6) summary
    smart00153
    Location:679 → 714
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 677
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  17. XM_006527044.5 → XP_006527107.1  actin-binding LIM protein 1 isoform X24

    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (6) summary
    smart00153
    Location:625 → 660
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:314 → 623
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  18. XM_017318179.3 → XP_017173668.1  actin-binding LIM protein 1 isoform X23

    UniProtKB/TrEMBL
    E9Q9C4
    Conserved Domains (6) summary
    smart00153
    Location:632 → 667
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 630
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  19. XM_006527041.5 → XP_006527104.1  actin-binding LIM protein 1 isoform X20

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:646 → 681
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 644
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  20. XM_017318178.3 → XP_017173667.1  actin-binding LIM protein 1 isoform X21

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:644 → 679
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 642
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  21. XM_017318181.3 → XP_017173670.1  actin-binding LIM protein 1 isoform X25

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:597 → 632
    VHP; Villin headpiece domain
    cd09327
    Location:36 → 87
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:92 → 147
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:163 → 214
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:222 → 277
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:286 → 595
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  22. XM_030250915.1 → XP_030106775.1  actin-binding LIM protein 1 isoform X17

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:668 → 703
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 666
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  23. XM_030250912.1 → XP_030106772.1  actin-binding LIM protein 1 isoform X8

    UniProtKB/TrEMBL
    Q3UP03
    Conserved Domains (6) summary
    smart00153
    Location:708 → 743
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:273 → 706
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  24. XM_017318174.3 → XP_017173663.1  actin-binding LIM protein 1 isoform X4

    UniProtKB/Swiss-Prot
    Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
    Conserved Domains (6) summary
    smart00153
    Location:736 → 771
    VHP; Villin headpiece domain
    cd09327
    Location:23 → 74
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:79 → 134
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:150 → 201
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:209 → 264
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:301 → 734
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  25. XM_017318173.3 → XP_017173662.1  actin-binding LIM protein 1 isoform X3

    UniProtKB/Swiss-Prot
    Q80U86, Q8BIR9, Q8K4G3, Q8K4G4, Q8K4G5
    Conserved Domains (6) summary
    smart00153
    Location:740 → 775
    VHP; Villin headpiece domain
    cd09327
    Location:27 → 78
    LIM1_abLIM; The first LIM domain of actin binding LIM (abLIM) proteins
    cd09328
    Location:83 → 138
    LIM2_abLIM; The second LIM domain on actin binding LIM (abLIM) proteins
    cd09329
    Location:154 → 205
    LIM3_abLIM; The third LIM domain of actin binding LIM (abLIM) proteins
    cd09330
    Location:213 → 268
    LIM4_abLIM; The fourth LIM domain of actin binding LIM (abLIM) proteins
    pfam16182
    Location:305 → 738
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  26. XM_017318183.2 → XP_017173672.1  actin-binding LIM protein 1 isoform X26

    UniProtKB/TrEMBL
    E9Q9D2
    Conserved Domains (3) summary
    smart00153
    Location:496 → 531
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:61 → 494
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  27. XM_017318182.3 → XP_017173671.1  actin-binding LIM protein 1 isoform X26

    UniProtKB/TrEMBL
    E9Q9D2
    Conserved Domains (3) summary
    smart00153
    Location:496 → 531
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:61 → 494
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  28. XM_006527048.5 → XP_006527111.1  actin-binding LIM protein 1 isoform X27

    UniProtKB/TrEMBL
    E9Q9D2
    Conserved Domains (3) summary
    smart00153
    Location:468 → 503
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 466
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  29. XM_030250918.2 → XP_030106778.1  actin-binding LIM protein 1 isoform X28

    UniProtKB/TrEMBL
    E9Q9D2
    Conserved Domains (3) summary
    smart00153
    Location:428 → 463
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 426
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  30. XM_030250919.2 → XP_030106779.1  actin-binding LIM protein 1 isoform X30

    UniProtKB/TrEMBL
    E9Q9D2
    Conserved Domains (3) summary
    smart00153
    Location:379 → 414
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 377
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  31. XM_017318184.3 → XP_017173673.1  actin-binding LIM protein 1 isoform X29

    UniProtKB/TrEMBL
    E9Q9Q7
    Conserved Domains (3) summary
    smart00153
    Location:393 → 428
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 391
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM

  32. XM_017318186.3 → XP_017173675.1  actin-binding LIM protein 1 isoform X31

    UniProtKB/TrEMBL
    E9Q9D2
    Conserved Domains (3) summary
    smart00153
    Location:344 → 379
    VHP; Villin headpiece domain
    cl02475
    Location:1 → 24
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
    pfam16182
    Location:33 → 342
    AbLIM_anchor; Putative adherens-junction anchoring region of AbLIM
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K4G5.1 GenPept UniProtKB/Swiss-Prot:Q8K4G5

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