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Map3k19 mitogen-activated protein kinase kinase kinase 19 [ Mus musculus (house mouse) ]

Gene ID: 22625, updated on 11-Apr-2024

Summary

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Official Symbol
Map3k19provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 19provided by MGI
Primary source
MGI:MGI:1203481
See related
Ensembl:ENSMUSG00000051590 AllianceGenome:MGI:1203481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ysk4
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation. Predicted to act upstream of or within phosphorylation. Is expressed in brain and spinal cord ventricular layer. Orthologous to human MAP3K19 (mitogen-activated protein kinase kinase kinase 19). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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See Map3k19 in Genome Data Viewer
Location:
1 E3; 1 55.8 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (127741217..127782763, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (127813480..127855026, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2900009J06 gene Neighboring gene amino carboxymuconate semialdehyde decarboxylase Neighboring gene STARR-positive B cell enhancer ABC_E3301 Neighboring gene cyclin T2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:129726872-129727109 Neighboring gene STARR-positive B cell enhancer ABC_E7742 Neighboring gene RAB3 GTPase activating protein subunit 1 Neighboring gene zinc finger, RAN-binding domain containing 3 Neighboring gene predicted gene 28800

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. YSK1, a novel mammalian protein kinase structurally related to Ste20 and SPS1, but is not involved in the known MAPK pathways. Osada S, et al. Oncogene, 1997 May 1. PMID 9160885
  2. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  4. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, et al. Nature, 2002 Dec 5. PMID 12466851
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 19
Names
SPS1/STE20-related protein kinase YSK4
Yeast Sps1/Ste20-related kinase 4
NP_035867.2
XP_036019612.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011737.2 → NP_035867.2  mitogen-activated protein kinase kinase kinase 19

    Status: VALIDATED

    Source sequence(s)
    AC121883, AC163690
    Consensus CDS
    CCDS48347.1
    UniProtKB/Swiss-Prot
    E9Q3S4
    UniProtKB/TrEMBL
    A0A140LHL6
    Related
    ENSMUSP00000146463.2, ENSMUST00000208183.3
    Conserved Domains (2) summary
    cd06631
    Location:1246 → 1511
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
    sd00045
    Location:44 → 74
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    127741217..127782763 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163719.1 → XP_036019612.1  mitogen-activated protein kinase kinase kinase 19 isoform X1

    UniProtKB/TrEMBL
    A0A087WS76
    Conserved Domains (1) summary
    cd06631
    Location:842 → 1107
    STKc_YSK4; Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E9Q3S4.1 GenPept UniProtKB/Swiss-Prot:E9Q3S4

Gene LinkOut

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