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Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 [ Mus musculus (house mouse) ]

Gene ID: 226169, updated on 21-Apr-2024

Summary

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Official Symbol
Pprc1provided by MGI
Official Full Name
peroxisome proliferative activated receptor, gamma, coactivator-related 1provided by MGI
Primary source
MGI:MGI:2385096
See related
Ensembl:ENSMUSG00000055491 AllianceGenome:MGI:2385096
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PRC; mKIAA0595; A930018M19
Summary
Predicted to enable nuclear receptor coactivator activity. Predicted to be involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; limb; and sensory organ. Orthologous to human PPRC1 (PPARG related coactivator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 14.9), ovary adult (RPKM 11.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.75 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46044955..46061348)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46056526..46072909)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930505N22 gene Neighboring gene HPS6, biogenesis of lysosomal organelles complex 2 subunit 3 Neighboring gene STARR-seq mESC enhancer starr_46294 Neighboring gene STARR-positive B cell enhancer ABC_E5707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46114769-46114954 Neighboring gene LIM domain binding 1 Neighboring gene STARR-positive B cell enhancer ABC_E1527 Neighboring gene STARR-positive B cell enhancer ABC_E7666 Neighboring gene nucleolar and coiled-body phosphoprotein 1 Neighboring gene ELOVL fatty acid elongase 3 Neighboring gene paired-like homeodomain transcription factor 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Resistance to high-fat diet-induced obesity in male heterozygous Pprc1 knockout mice. Zhai N, et al. Endocr J, 2015. PMID 25994039
  2. Peri-implantation lethality in mice lacking the PGC-1-related coactivator protein. He X, et al. Dev Dyn, 2012 May. PMID 22411706
  3. Short hairpin RNA-mediated silencing of PRC (PGC-1-related coactivator) results in a severe respiratory chain deficiency associated with the proliferation of aberrant mitochondria. Vercauteren K, et al. J Biol Chem, 2009 Jan 23. PMID 19036724, Free PMC Article
  4. Genome-Wide Association Study to Identify Genes Related to Renal Mercury Concentrations in Mice. Alkaissi H, et al. Environ Health Perspect, 2016 Jul. PMID 26942574, Free PMC Article
  5. New insights into PGC-1 coactivators: redefining their role in the regulation of mitochondrial function and beyond. Villena JA. FEBS J, 2015 Feb. PMID 25495651

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC12121

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nuclear receptor coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
enables transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in positive regulation of DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Names
PGC-1-related coactivator

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081214.1 → NP_001074683.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001074683.1

    Status: VALIDATED

    Source sequence(s)
    AC140233
    Consensus CDS
    CCDS38005.1
    UniProtKB/Swiss-Prot
    Q3UGG3, Q6NZN1, Q80TW6, Q8BXP6, Q91YW8
    Related
    ENSMUSP00000107530.2, ENSMUST00000111899.8
    Conserved Domains (1) summary
    cd12624
    Location:1521 → 1611
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  2. NM_001346801.1 → NP_001333730.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140233
    Consensus CDS
    CCDS89404.1
    UniProtKB/Swiss-Prot
    Q6NZN1
    Related
    ENSMUSP00000079389.4, ENSMUST00000062322.11

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46044955..46061348
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527008.4 → XP_006527071.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X3

    Conserved Domains (2) summary
    PHA03247
    Location:582 → 1120
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1521 → 1611
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  2. XM_030250903.2 → XP_030106763.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6

    Conserved Domains (2) summary
    PHA03247
    Location:988 → 1383
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1520 → 1610
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  3. XM_006527009.4 → XP_006527072.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X4

    Conserved Domains (2) summary
    PHA03247
    Location:579 → 1117
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1520 → 1610
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  4. XM_006527007.4 → XP_006527070.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X1

    Conserved Domains (2) summary
    PHA03247
    Location:581 → 1119
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1522 → 1612
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  5. XM_030250902.2 → XP_030106762.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X5

    Conserved Domains (2) summary
    PHA03247
    Location:581 → 1119
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1520 → 1610
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  6. XM_030250905.2 → XP_030106765.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X8

    Conserved Domains (2) summary
    PHA03247
    Location:987 → 1382
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1519 → 1609
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  7. XM_011247239.3 → XP_011245541.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X7

    Conserved Domains (2) summary
    PHA03247
    Location:578 → 1116
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1519 → 1609
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  8. XM_030250906.2 → XP_030106766.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X9

    Conserved Domains (2) summary
    PHA03247
    Location:984 → 1379
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1518 → 1608
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  9. XM_036161570.1 → XP_036017463.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X12

    Conserved Domains (2) summary
    PHA03247
    Location:984 → 1379
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1516 → 1606
    RRM_PRC; RNA recognition motif (RRM) found in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  10. XM_017318166.3 → XP_017173655.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2

    UniProtKB/Swiss-Prot
    Q6NZN1
    Conserved Domains (2) summary
    PHA03247
    Location:988 → 1383
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1522 → 1612
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  11. XM_006527010.3 → XP_006527073.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10

    Conserved Domains (2) summary
    PHA03247
    Location:576 → 1114
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1517 → 1607
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  12. XM_006527011.3 → XP_006527074.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X11

    Conserved Domains (2) summary
    PHA03247
    Location:575 → 1113
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1516 → 1606
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  13. XM_011247240.4 → XP_011245542.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X13

    Conserved Domains (2) summary
    PHA03247
    Location:535 → 1073
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1476 → 1566
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

  14. XM_011247241.2 → XP_011245543.1  peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X14

    Conserved Domains (2) summary
    PHA03247
    Location:466 → 1004
    PHA03247; large tegument protein UL36; Provisional
    cd12624
    Location:1405 → 1495
    RRM_PRC; RNA recognition motif in peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PRC) and similar proteins

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145504.1: Suppressed sequence

    Description
    NM_145504.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZN1.1 GenPept UniProtKB/Swiss-Prot:Q6NZN1

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