Opalin oligodendrocytic myelin paranodal and inner loop protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Opalinprovided by MGI
Official Full Name: oligodendrocytic myelin paranodal and inner loop proteinprovided by MGI
Primary source: MGI:MGI:2657025
See related: Ensembl:ENSMUSG00000050121 AllianceGenome:MGI:2657025
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmp10; Tmem10
Summary: Involved in regulation of oligodendrocyte differentiation. Located in cell-cell contact zone and plasma membrane. Is expressed in brain; spinal cord; and visual system. Orthologous to human OPALIN (oligodendrocytic myelin paranodal and inner loop protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cortex adult (RPKM 19.3), cerebellum adult (RPKM 18.7) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 34.36 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (41050398..41065552, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (41061959..41077113, complement)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35.
Title: Decreased turnover of the CNS myelin protein Opalin in a mouse model of hereditary spastic paraplegia 35.
study demonstrates that Tmem10 can be used as a specific marker for myelinating oligodendrocytes and perhaps for the evaluation of myelination diseases, such as multiple sclerosis
Title: Identification of Tmem10 as a novel late-stage oligodendrocytes marker for detecting hypomyelination.
Tmem10 plays a possible role in oligodendrocyte differentiation and myelination of the central nervous system.
Title: Identification of Tmem10/Opalin as an oligodendrocyte enriched gene using expression profiling combined with genetic cell ablation.
highly sialylglycosylated Opalin has a role in an intermembranous function of the myelin paranodal loops in the central nervous system
Title: Opalin, a transmembrane sialylglycoprotein located in the central nervous system myelin paranodal loop membrane.
Together, our results demonstrate that Tmem10 is a novel marker for in vitro generated oligodendrocytes.
Title: Identification of Tmem10/Opalin as a novel marker for oligodendrocytes using gene expression profiling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

Opalin (e-PCR), detects polymorphism
- UniSTS:531457

09.MMHAP34FRC9.seq (e-PCR)
- UniSTS:122972

Opalin (e-PCR), detects polymorphism
- UniSTS:531422

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in regulation of oligodendrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: opalin

Names: transmembrane protein 10; transmembrane protein TMP10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.