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Hectd2 HECT domain E3 ubiquitin protein ligase 2 [ Mus musculus (house mouse) ]

Gene ID: 226098, updated on 12-May-2024

Summary

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Official Symbol
Hectd2provided by MGI
Official Full Name
HECT domain E3 ubiquitin protein ligase 2provided by MGI
Primary source
MGI:MGI:2442663
See related
Ensembl:ENSMUSG00000041180 AllianceGenome:MGI:2442663
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4921524L07; A630025O09Rik
Summary
Predicted to enable ubiquitin-protein transferase activity. Is expressed in brain; large intestine; lymph node; and male reproductive gland or organ. Orthologous to human HECTD2 (HECT domain E3 ubiquitin protein ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E18 (RPKM 4.4), whole brain E14.5 (RPKM 3.6) and 16 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C2; 19 31.77 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (36531420..36598535)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (36554126..36621135)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32143 Neighboring gene predicted gene, 41838 Neighboring gene Hectd2, opposite strand Neighboring gene STARR-seq mESC enhancer starr_46028 Neighboring gene STARR-seq mESC enhancer starr_46029 Neighboring gene protein phosphatase 1, regulatory subunit 3C Neighboring gene predicted gene, 57662

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. HECTD2 is associated with susceptibility to mouse and human prion disease. Lloyd SE, et al. PLoS Genet, 2009 Feb. PMID 19214206, Free PMC Article
  2. The proinflammatory role of HECTD2 in innate immunity and experimental lung injury. Coon TA, et al. Sci Transl Med, 2015 Jul 8. PMID 26157031, Free PMC Article
  3. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
  4. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase HECTD2
Names
HECT domain containing 2
HECT domain-containing protein 2
HECT-type E3 ubiquitin transferase HECTD2
NP_001156943.1
NP_766225.2
XP_006527054.1
XP_017173648.1
XP_030106754.1
XP_030106755.1
XP_036017457.1
XP_036017458.1
XP_036017459.1
XP_036017460.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163471.1 → NP_001156943.1  probable E3 ubiquitin-protein ligase HECTD2 isoform 1

    See identical proteins and their annotated locations for NP_001156943.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK029549, AK142777, BE864574, BP754340, CB526486
    Consensus CDS
    CCDS50425.1
    UniProtKB/TrEMBL
    B2RPZ5
    Related
    ENSMUSP00000128387.3, ENSMUST00000169036.9
    Conserved Domains (2) summary
    smart00119
    Location:439 → 772
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:416 → 773
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. NM_172637.3 → NP_766225.2  probable E3 ubiquitin-protein ligase HECTD2 isoform 2

    See identical proteins and their annotated locations for NP_766225.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the middle portion of the coding region, compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AK029549, AK142777, BP754340, CB526486
    Consensus CDS
    CCDS29773.1
    UniProtKB/Swiss-Prot
    E9QK99, Q8CBQ9, Q8CDU6
    Related
    ENSMUSP00000042646.6, ENSMUST00000047247.12
    Conserved Domains (2) summary
    smart00119
    Location:438 → 771
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:415 → 772
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    36531420..36598535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526991.5 → XP_006527054.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X1

    Conserved Domains (1) summary
    cd00078
    Location:313 → 670
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. XM_036161567.1 → XP_036017460.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X6

    Conserved Domains (1) summary
    cd00078
    Location:67 → 424
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  3. XM_030250895.1 → XP_030106755.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

    Conserved Domains (1) summary
    cd00078
    Location:154 → 511
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  4. XM_036161564.1 → XP_036017457.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    Conserved Domains (1) summary
    cd00078
    Location:155 → 512
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  5. XM_030250894.1 → XP_030106754.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X3

    Conserved Domains (1) summary
    cd00078
    Location:155 → 512
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  6. XM_036161565.1 → XP_036017458.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X4

    Conserved Domains (1) summary
    cd00078
    Location:154 → 511
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  7. XM_036161566.1 → XP_036017459.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X5

    Conserved Domains (1) summary
    cd00078
    Location:68 → 425
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  8. XM_017318159.3 → XP_017173648.1  probable E3 ubiquitin-protein ligase HECTD2 isoform X2

    Conserved Domains (1) summary
    cd00078
    Location:166 → 523
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

RNA

  1. XR_003952783.1 RNA Sequence

    Related
    ENSMUST00000139215.8

  2. XR_003952784.1 RNA Sequence

  3. XR_004940139.1 RNA Sequence

  4. XR_001782583.2 RNA Sequence

  5. XR_004940140.1 RNA Sequence

  6. XR_003952787.1 RNA Sequence

  7. XR_003952788.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDU6.2 GenPept UniProtKB/Swiss-Prot:Q8CDU6

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