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Abhd17b abhydrolase domain containing 17B [ Mus musculus (house mouse) ]

Gene ID: 226016, updated on 11-Apr-2024

Summary

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Official Symbol
Abhd17bprovided by MGI
Official Full Name
abhydrolase domain containing 17Bprovided by MGI
Primary source
MGI:MGI:1917816
See related
Ensembl:ENSMUSG00000047368 AllianceGenome:MGI:1917816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgi67; Fam108b; Fam108b1; 5730446C15Rik
Summary
Enables palmitoyl-(protein) hydrolase activity. Involved in several processes, including negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; and protein depalmitoylation. Located in plasma membrane; postsynaptic density; and recycling endosome membrane. Orthologous to human ABHD17B (abhydrolase domain containing 17B, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 19.0), cerebellum adult (RPKM 9.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Abhd17b in Genome Data Viewer
Location:
19 B; 19 15.54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (21630483..21663002)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (21653267..21685638)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38486 Neighboring gene RIKEN cDNA 1110059E24 gene Neighboring gene STARR-seq mESC enhancer starr_45727 Neighboring gene STARR-positive B cell enhancer mm9_chr19:21727198-21727499 Neighboring gene STARR-positive B cell enhancer mm9_chr19:21788111-21788412 Neighboring gene predicted gene, 41818 Neighboring gene STARR-positive B cell enhancer ABC_E9993 Neighboring gene STARR-positive B cell enhancer ABC_E9994 Neighboring gene VISTA enhancer mm1610 Neighboring gene STARR-seq mESC enhancer starr_45737 Neighboring gene STARR-seq mESC enhancer starr_45738 Neighboring gene cell migration inducing hyaluronidase 2 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Tortosa E, et al. Neuron, 2017 May 17. PMID 28521134
  2. Identification of PSD-95 Depalmitoylating Enzymes. Yokoi N, et al. J Neurosci, 2016 Jun 15. PMID 27307232, Free PMC Article
  3. Human and mouse proteases: a comparative genomic approach. Puente XS, et al. Nat Rev Genet, 2003 Jul. PMID 12838346
  4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
  5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC40949

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-(protein) hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables palmitoyl-(protein) hydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables palmitoyl-(protein) hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of protein localization to microtubule IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein localization to endosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein depalmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein depalmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein depalmitoylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of dendritic spine maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of postsynapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein localization to synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic density membrane ISO
Inferred from Sequence Orthology
more info
  
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha/beta hydrolase domain-containing protein 17B
Names
Cgi67 serine protease
abhydrolase domain-containing protein 17B
abhydrolase domain-containing protein FAM108B1
family with sequence similarity 108, member B
protein ABHD17B
NP_666208.2
XP_011245530.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_146096.3 → NP_666208.2  alpha/beta hydrolase domain-containing protein 17B precursor

    See identical proteins and their annotated locations for NP_666208.2

    Status: VALIDATED

    Source sequence(s)
    AK050879, BM206433, BN000127
    Consensus CDS
    CCDS29700.1
    UniProtKB/Swiss-Prot
    Q58EV9, Q7M759, Q8K275
    Related
    ENSMUSP00000056099.4, ENSMUST00000052556.5
    Conserved Domains (1) summary
    COG1073
    Location:93 → 285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    21630483..21663002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011247228.4 → XP_011245530.1  alpha/beta hydrolase domain-containing protein 17B isoform X1

    See identical proteins and their annotated locations for XP_011245530.1

    UniProtKB/Swiss-Prot
    Q58EV9, Q7M759, Q8K275
    Conserved Domains (1) summary
    COG1073
    Location:93 → 285
    FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7M759.1 GenPept UniProtKB/Swiss-Prot:Q7M759

Gene LinkOut

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