Trpm6 transient receptor potential cation channel, subfamily M, member 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trpm6provided by MGI
Official Full Name: transient receptor potential cation channel, subfamily M, member 6provided by MGI
Primary source: MGI:MGI:2675603
See related: Ensembl:ENSMUSG00000024727 AllianceGenome:MGI:2675603
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CHAK2; TRPM6/CHAK2
Summary: Enables cation channel activity. Acts upstream of or within metal ion transport. Located in apical plasma membrane and brush border membrane. Is expressed in several structures, including cochlea; colon; extraembryonic component; ganglia; and genitourinary system. Human ortholog(s) of this gene implicated in intestinal hypomagnesemia 1 and metal metabolism disorder. Orthologous to human TRPM6 (transient receptor potential cation channel subfamily M member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 3.2), lung adult (RPKM 1.8) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 B; 19 13.21 cM

Exon count:: 44

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (18707566..18869885)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (18730177..18892521)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.
Title: Importance of the renal ion channel TRPM6 in the circadian secretion of renin to raise blood pressure.
increased urinary UMOD secretion in low-magnesium states reduces TRPM6 endocytosis and thereby up-regulates TRPM6 cell-surface abundance to defend against further urinary magn
Title: Uromodulin regulates renal magnesium homeostasis through the ion channel transient receptor potential melastatin 6 (TRPM6).
mTRPM6 and mTRPM7 contribute differentially to key functional characteristics of mTRPM6/7 complexes thereby functionally defining a new type of channel that remains active in the presence of physiological concentrations of [Mg2+]i and [Mg.ATP]i.
Title: TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg(2+) and Mg·ATP.
Hence, maintenance of organismal Mg(2+) balance by TRPM6 is crucial for prenatal development and survival to adulthood.
Title: Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival.
TRPM6 mRNA increased during the last 4 days of pregnancy, coinciding with fetal bone mineralization in mice. TRPM6 mRNA and protein was localized in the trophoblasts in labyrinth where the maternal-fetal Ca(2+) transport occurs. In patch-clamp recordings, we observed TRPM6/TRPM7-like currents in mouse trophoblasts after starting fetal bone mineralization but not before mineralization.
Title: Expression of the TRPM6 in mouse placental trophoblasts; potential role in maternal-fetal calcium transport.
in a model of inherited hypomagnesemia, TRPM6 and TRPM7, but not paracellin-1, are downregulated
Title: Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia.
TRPM6 deletion is embryonic lethal in mice; Heterozygous deletion of TRPM6 results in a mild hypomagnesemia
Title: Transient receptor potential melastatin 6 knockout mice are lethal whereas heterozygous deletion results in mild hypomagnesemia.
consistently reduced expression of TRPM6 mRNA may play a role in the pathogenesis of hypomagnesemia in C57BL/6 asthmatic mice.
Title: Decreased renal mRNA expression of TRPM6 is associated with hypomagnesemia in C57BL/6 asthmatic mice.
MsrB1 recovers TRPM6 channel activity by reducing the oxidation of Met(1755) and could, thereby, function as a modulator of TRPM6 during oxidative stress.
Title: Methionine sulfoxide reductase B1 (MsrB1) recovers TRPM6 channel activity during oxidative stress.
Trpm6(-/-) mice almost never survived to weaning and show neural tube defects.
Title: Mice defective in Trpm6 show embryonic mortality and neural tube defects.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Trpm6 (e-PCR), detects polymorphism
- UniSTS:531251

Trpm6 (e-PCR), detects polymorphism
- UniSTS:527194

Trpm6 (e-PCR), detects polymorphism
- UniSTS:530854

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monoatomic cation channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic cation channel activity	IDA Inferred from Direct Assay more info	PubMed
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in metal ion transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within metal ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic cation transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein tetramerization	IEA Inferred from Electronic Annotation more info
involved_in response to toxic substance	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transient receptor potential cation channel subfamily M member 6

Names: melastatin-related TRP cation channel 6; putative cation channel subfamily M member 6; transient receptor potential cation channel 6/channel-kinase 2

NP_700466.1

EC 2.7.11.1

XP_006527014.1

EC 2.7.11.1

XP_006527015.1

EC 2.7.11.1

XP_011245528.1

EC 2.7.11.1

XP_017173641.1

EC 2.7.11.1

XP_017173642.1

EC 2.7.11.1

XP_030106746.1

EC 2.7.11.1

XP_036017442.1

EC 2.7.11.1

XP_036017443.1

EC 2.7.11.1

XP_036017444.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153417.2 → NP_700466.1 transient receptor potential cation channel subfamily M member 6

See identical proteins and their annotated locations for NP_700466.1

Status: VALIDATED

Source sequence(s)

AC134906, AC140458

Consensus CDS

CCDS29691.1

UniProtKB/Swiss-Prot

Q8CIR4

UniProtKB/TrEMBL

A0A1W5LU38

Related

ENSMUSP00000037443.8, ENSMUST00000040489.9

Conserved Domains (3) summary

smart00811
Location:1760 → 1978

Alpha_kinase; Alpha-kinase family

pfam16519
Location:1180 → 1231

TRPM_tetra; Tetramerisation domain of TRPM

cl26777
Location:661 → 1111

TRP_2; Transient receptor ion channel II

RNA

NR_157571.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC134906, AC140458

Related

ENSMUST00000236199.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

18707566..18869885

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526951.4 → XP_006527014.1 transient receptor potential cation channel subfamily M member 6 isoform X1

Conserved Domains (4) summary

TIGR00870
Location:660 → 1110

trp; transient-receptor-potential calcium channel protein

cd16972
Location:1741 → 1979

Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6

pfam16519
Location:1175 → 1230

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:99 → 362

LSDAT_euk; SLOG in TRPM
XM_017318152.2 → XP_017173641.1 transient receptor potential cation channel subfamily M member 6 isoform X1

Conserved Domains (4) summary

TIGR00870
Location:660 → 1110

trp; transient-receptor-potential calcium channel protein

cd16972
Location:1741 → 1979

Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6

pfam16519
Location:1175 → 1230

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:99 → 362

LSDAT_euk; SLOG in TRPM
XM_030250886.2 → XP_030106746.1 transient receptor potential cation channel subfamily M member 6 isoform X6

Conserved Domains (4) summary

TIGR00870
Location:544 → 994

trp; transient-receptor-potential calcium channel protein

cd16972
Location:1625 → 1863

Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6

pfam16519
Location:1059 → 1114

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:1 → 246

LSDAT_euk; SLOG in TRPM
XM_017318153.3 → XP_017173642.1 transient receptor potential cation channel subfamily M member 6 isoform X2

Conserved Domains (4) summary

TIGR00870
Location:661 → 1111

trp; transient-receptor-potential calcium channel protein

cd16972
Location:1741 → 1979

Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6

pfam16519
Location:1176 → 1231

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:100 → 363

LSDAT_euk; SLOG in TRPM
XM_036161550.1 → XP_036017443.1 transient receptor potential cation channel subfamily M member 6 isoform X5

Conserved Domains (4) summary

TIGR00870
Location:905 → 1068

trp; transient-receptor-potential calcium channel protein

cd16972
Location:1699 → 1937

Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6

pfam16519
Location:1133 → 1187

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:101 → 363

LSDAT_euk; SLOG in TRPM
XM_036161549.1 → XP_036017442.1 transient receptor potential cation channel subfamily M member 6 isoform X3

Conserved Domains (4) summary

TIGR00870
Location:648 → 1098

trp; transient-receptor-potential calcium channel protein

cd16972
Location:1729 → 1967

Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6

pfam16519
Location:1163 → 1217

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:88 → 350

LSDAT_euk; SLOG in TRPM
XM_036161551.1 → XP_036017444.1 transient receptor potential cation channel subfamily M member 6 isoform X7

Conserved Domains (1) summary

pfam18139
Location:101 → 339

LSDAT_euk; SLOG in TRPM
XM_006526952.4 → XP_006527015.1 transient receptor potential cation channel subfamily M member 6 isoform X8

Conserved Domains (1) summary

pfam18139
Location:100 → 328

LSDAT_euk; SLOG in TRPM
XM_011247226.3 → XP_011245528.1 transient receptor potential cation channel subfamily M member 6 isoform X4

Conserved Domains (4) summary

TIGR00870
Location:645 → 1095

trp; transient-receptor-potential calcium channel protein

cd16972
Location:1726 → 1964

Alpha_kinase_ChaK2_TRPM6; Alpha-kinase domain of channel kinase 2, also called transient receptor potential cation channel subfamily M member 6

pfam16519
Location:1160 → 1215

TRPM_tetra; Tetramerisation domain of TRPM

pfam18139
Location:84 → 347

LSDAT_euk; SLOG in TRPM