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Ubxn1 UBX domain protein 1 [ Mus musculus (house mouse) ]

Gene ID: 225896, updated on 5-Mar-2024

Summary

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Official Symbol
Ubxn1provided by MGI
Official Full Name
UBX domain protein 1provided by MGI
Primary source
MGI:MGI:1289301
See related
Ensembl:ENSMUSG00000071655 AllianceGenome:MGI:1289301
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2B28; mY33K; D19Ertd721e; 4930455J02Rik
Summary
Predicted to enable several functions, including enzyme binding activity; polyubiquitin modification-dependent protein binding activity; and proteasome regulatory particle binding activity. Predicted to be involved in negative regulation of cellular protein metabolic process. Predicted to be located in several cellular components, including dendrite; neuronal cell body; and nucleoplasm. Predicted to be part of VCP-NPL4-UFD1 AAA ATPase complex. Is expressed in pancreas epithelium. Orthologous to human UBXN1 (UBX domain protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 89.4), CNS E11.5 (RPKM 86.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 5.88 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (8848912..8853030)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (8871548..8875666)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene BSCL2 lipid droplet biogenesis associated, seipin Neighboring gene guanine nucleotide binding protein (G protein), gamma 3 Neighboring gene LRRN4 C-terminal like Neighboring gene STARR-seq mESC enhancer starr_45500 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:8955290-8955473 Neighboring gene ubiquinol-cytochrome c reductase complex assembly factor 3 Neighboring gene RIKEN cDNA 5730408K05 gene Neighboring gene STARR-positive B cell enhancer ABC_E11017 Neighboring gene LBH domain containing 1 Neighboring gene small nucleolar RNA, H/ACA box 57

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel protein specifically interacting with Homer2 regulates ubiquitin-proteasome systems. Ishibashi T, et al. J Biochem, 2005 May. PMID 15944415
  2. The AAA ATPase p97 links peptide N-glycanase to the endoplasmic reticulum-associated E3 ligase autocrine motility factor receptor. Li G, et al. Proc Natl Acad Sci U S A, 2006 May 30. PMID 16709668, Free PMC Article
  3. Identification of proteins that interact with mammalian peptide:N-glycanase and implicate this hydrolase in the proteasome-dependent pathway for protein degradation. Park H, et al. Proc Natl Acad Sci U S A, 2001 Sep 25. PMID 11562482, Free PMC Article
  4. An 'equalized cDNA library' by the reassociation of short double-stranded cDNAs. Ko MS. Nucleic Acids Res, 1990 Oct 11. PMID 2216762, Free PMC Article
  5. The AAA-ATPase ATAD1 and its partners promote degradation of desmin intermediate filaments in muscle. Aweida D, et al. EMBO Rep, 2022 Dec 6. PMID 36278411, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC6696

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATPase binding ISO
Inferred from Sequence Orthology
more info
  
enables K48-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables K6-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables proteasome regulatory particle binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERAD pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein K48-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ubiquitin-specific protease activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
UBX domain-containing protein 1
Names
SAPK substrate protein 1
UBA/UBX 33.3 kDa protein
protein 2B28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362044.1 → NP_001348973.1  UBX domain-containing protein 1

    Status: VALIDATED

    Source sequence(s)
    AK150442, BY238872, BY606648, CX123666
    Consensus CDS
    CCDS29553.1
    UniProtKB/Swiss-Prot
    Q3UCP8, Q922Y1
    UniProtKB/TrEMBL
    A0A498WFS2
    Related
    ENSMUSP00000157971.2, ENSMUST00000238036.2
    Conserved Domains (2) summary
    cd01772
    Location:210 → 293
    SAKS1_UBX; SAKS1-like UBX domain
    cd14302
    Location:5 → 45
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins

  2. NM_146093.2 → NP_666205.1  UBX domain-containing protein 1

    See identical proteins and their annotated locations for NP_666205.1

    Status: VALIDATED

    Source sequence(s)
    AC129217
    Consensus CDS
    CCDS29553.1
    UniProtKB/Swiss-Prot
    Q3UCP8, Q922Y1
    UniProtKB/TrEMBL
    A0A498WFS2
    Related
    ENSMUSP00000133250.2, ENSMUST00000166407.9
    Conserved Domains (2) summary
    cd01772
    Location:210 → 293
    SAKS1_UBX; SAKS1-like UBX domain
    cd14302
    Location:5 → 45
    UBA_UBXN1; UBA domain found in UBX domain-containing protein 1 (UBXN1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    8848912..8853030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q922Y1.1 GenPept UniProtKB/Swiss-Prot:Q922Y1

Gene LinkOut

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