Plaat3 phospholipase A and acyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plaat3provided by MGI
Official Full Name: phospholipase A and acyltransferase 3provided by MGI
Primary source: MGI:MGI:2179715
See related: Ensembl:ENSMUSG00000060675 AllianceGenome:MGI:2179715
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AdPLA; HRSL3; MLP-3; Hrasls3; Hrev107; Pla2g16
Summary: Enables phospholipase A1 activity and phospholipase A2 activity. Involved in several processes, including ether lipid metabolic process; lens fiber cell differentiation; and triglyceride metabolic process. Acts upstream of or within response to bacterium. Located in several cellular components, including nuclear envelope; perinuclear region of cytoplasm; and peroxisome. Orthologous to human PLAAT3 (phospholipase A and acyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in subcutaneous fat pad adult (RPKM 47.3), genital fat pad adult (RPKM 30.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 A; 19 5.33 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (7534824..7565914)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (7557459..7588545)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Organelle degradation in the lens by PLAAT phospholipases.
Title: Organelle degradation in the lens by PLAAT phospholipases.
Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
Title: Skeletal muscle expression of adipose-specific phospholipase in peripheral artery disease.
several mutant p53 proteins bind the Pla2g16 promoter at E26 transformation-specific (ETS) binding motifs and knockdown of ETS2 suppressed mutant p53 induction of Pla2g16.
Title: Pla2g16 phospholipase mediates gain-of-function activities of mutant p53.
H-rev107, through PTGDS, suppressed cell migration and invasion. Data suggest that the PGD2-cAMP-SOX9 signal pathway might play an important role in H-rev107-mediated cancer cell invasion in testes.
Title: H-rev107 regulates prostaglandin D2 synthase-mediated suppression of cellular invasion in testicular cancer cells.
H-rev107 interferes with the biosynthesis of ether-type lipids and is responsible for the dysfunction of peroxisomes in H-rev107-expressing cells.
Title: Regulation of peroxisomal lipid metabolism by catalytic activity of tumor suppressor H-rev107.
HRASLS3 as one of the downstream effectors of PPARgamma action in adipogenesis.
Title: HRASLS3 is a PPARgamma-selective target gene that promotes adipocyte differentiation.
study found that AdPLA that was previously known as H-Rev-107/HRASLS3 is an adipose-specific, calcium-dependent histidine PLA2
Title: Identification and functional characterization of adipose-specific phospholipase A2 (AdPLA).
identification of an Sp1/Sp3-binding GC-box required for the transcription of H-rev107 (H-rev107)
Title: Murine H-rev107 gene encoding a class II tumor suppressor: gene organization and identification of an Sp1/Sp3-binding GC-box required for its transcription.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-acyl-2-lysophosphatidylserine acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables N-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acyltransferase activity	ISO Inferred from Sequence Orthology more info
NOT enables acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine 1-acylhydrolase activity	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A1 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A1 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	ISO Inferred from Sequence Orthology more info
enables phospholipase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in N-acylphosphatidylethanolamine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in N-acylphosphatidylethanolamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in ether lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lens fiber cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in localization	ISO Inferred from Sequence Orthology more info
involved_in membrane disassembly	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in organelle disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peroxisome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of adipose tissue development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in triglyceride metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phospholipase A and acyltransferase 3

Names: H-rev 107 protein homolog; HRAS-like suppressor 3; LRAT-like protein 3; adipose-specific phospholipase A2; group XVI phospholipase A1/A2; group XVI phospholipase A2; phospholipase A2, group XVI

NP_001349354.1

EC 3.1.1.32

EC 3.1.1.4

NP_001412813.1

EC 3.1.1.32

EC 3.1.1.4

NP_644675.2

EC 3.1.1.32

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362425.1 → NP_001349354.1 phospholipase A and acyltransferase 3

Status: VALIDATED

Source sequence(s)

AC109225, AK039703

Consensus CDS

CCDS29528.1

UniProtKB/Swiss-Prot

B7X6T3, Q3V3C3, Q8BWF7, Q8R3U1

Related

ENSMUSP00000115151.2, ENSMUST00000136756.2

Conserved Domains (2) summary

pfam04970
Location:21 → 125

LRAT; Lecithin retinol acyltransferase

cl21534
Location:3 → 35

NLPC_P60; NlpC/P60 family
NM_001425884.1 → NP_001412813.1 phospholipase A and acyltransferase 3 isoform 2

Status: VALIDATED

Source sequence(s)

AC109225
NM_139269.2 → NP_644675.2 phospholipase A and acyltransferase 3

See identical proteins and their annotated locations for NP_644675.2

Status: VALIDATED

Source sequence(s)

AK038809, AK163505

Consensus CDS

CCDS29528.1

UniProtKB/Swiss-Prot

B7X6T3, Q3V3C3, Q8BWF7, Q8R3U1

Related

ENSMUSP00000025925.5, ENSMUST00000025925.11

Conserved Domains (2) summary

pfam04970
Location:21 → 125

LRAT; Lecithin retinol acyltransferase

cl21534
Location:3 → 35

NLPC_P60; NlpC/P60 family