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Ptgr3 prostaglandin reductase 3 [ Mus musculus (house mouse) ]

Gene ID: 225791, updated on 5-Mar-2024

Summary

Official Symbol
Ptgr3provided by MGI
Official Full Name
prostaglandin reductase 3provided by MGI
Primary source
MGI:MGI:2444835
See related
Ensembl:ENSMUSG00000049090 AllianceGenome:MGI:2444835
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pthr3; Zadh2; PTGR-3; C530046K17Rik
Summary
Enables 13-prostaglandin reductase activity. Involved in negative regulation of fat cell differentiation. Located in peroxisome. Orthologous to human ZADH2 (zinc binding alcohol dehydrogenase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 15.8), ovary adult (RPKM 15.6) and 28 other tissues See more
Orthologs
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Genomic context

Location:
18 E4; 18 57.53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84106250..84115579)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84088126..84097528)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31792 Neighboring gene teashirt zinc finger family member 1 Neighboring gene STARR-positive B cell enhancer ABC_E11664 Neighboring gene predicted gene, 31854 Neighboring gene STARR-seq mESC enhancer starr_45246 Neighboring gene zinc finger protein 407 Neighboring gene STARR-seq mESC enhancer starr_45247 Neighboring gene predicted gene, 57824

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
prostaglandin reductase-3
Names
15-oxoprostaglandin 13-reductase
zinc binding alcohol dehydrogenase, domain containing 2
zinc-binding alcohol dehydrogenase domain-containing protein 2
NP_001404766.1
NP_001404768.1
NP_001404769.1
NP_666202.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417837.1NP_001404766.1  prostaglandin reductase-3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC124012
  2. NM_001417839.1NP_001404768.1  prostaglandin reductase-3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124012
  3. NM_001417840.1NP_001404769.1  prostaglandin reductase-3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC124012
    UniProtKB/TrEMBL
    A0A494BB38
    Related
    ENSMUSP00000158299.2, ENSMUST00000235383.2
  4. NM_146090.6NP_666202.2  prostaglandin reductase-3 isoform 1

    See identical proteins and their annotated locations for NP_666202.2

    Status: VALIDATED

    Source sequence(s)
    AC124012
    Consensus CDS
    CCDS29381.1
    UniProtKB/Swiss-Prot
    Q8BGC4
    UniProtKB/TrEMBL
    Q14AZ9
    Related
    ENSMUSP00000052544.3, ENSMUST00000060223.4
    Conserved Domains (2) summary
    cd08250
    Location:32368
    Mgc45594_like; Mgc45594 gene product and other MDR family members
    COG0604
    Location:33368
    Qor; NADPH:quinone reductase or related Zn-dependent oxidoreductase [Energy production and conversion, General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    84106250..84115579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)