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Cep76 centrosomal protein 76 [ Mus musculus (house mouse) ]

Gene ID: 225659, updated on 5-Mar-2024

Summary

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Official Symbol
Cep76provided by MGI
Official Full Name
centrosomal protein 76provided by MGI
Primary source
MGI:MGI:1923401
See related
Ensembl:ENSMUSG00000073542 AllianceGenome:MGI:1923401
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9630013E05; 6230425F05Rik
Summary
Predicted to be involved in regulation of centriole replication. Predicted to be located in centriole and centrosome. Predicted to be part of protein-containing complex. Is expressed in ductus deferens; prostate gland; and testis. Orthologous to human CEP76 (centrosomal protein 76). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in liver E14 (RPKM 12.6), liver E14.5 (RPKM 11.9) and 24 other tissues See more
Orthologs
human all
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Genomic context

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See Cep76 in Genome Data Viewer
Location:
18 E1; 18 40.04 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67750034..67774425, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67616964..67641355, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene PRELI domain containing 3A Neighboring gene spire type actin nucleation factor 1 Neighboring gene STARR-seq mESC enhancer starr_44904 Neighboring gene STARR-seq mESC enhancer starr_44905 Neighboring gene STARR-seq mESC enhancer starr_44907 Neighboring gene predicted gene, 17669 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67771962-67772263 Neighboring gene proteasome (prosome, macropain) assembly chaperone 2 Neighboring gene protein tyrosine phosphatase, non-receptor type 2 Neighboring gene STARR-positive B cell enhancer ABC_E11000 Neighboring gene STARR-positive B cell enhancer ABC_E8723

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
  2. Systematic analysis of human protein complexes identifies chromosome segregation proteins. Hutchins JR, et al. Science, 2010 Apr 30. PMID 20360068, Free PMC Article
  3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in regulation of centriole replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of centriole replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
centrosomal protein of 76 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081073.2 → NP_001074542.1  centrosomal protein of 76 kDa isoform 1

    See identical proteins and their annotated locations for NP_001074542.1

    Status: VALIDATED

    Source sequence(s)
    AC120410
    Consensus CDS
    CCDS37850.1
    UniProtKB/Swiss-Prot
    Q0VEJ0
    Related
    ENSMUSP00000095149.3, ENSMUST00000097542.4
    Conserved Domains (2) summary
    pfam01841
    Location:365 → 411
    Transglut_core; Transglutaminase-like superfamily
    pfam15627
    Location:101 → 258
    CEP76-C2; CEP76 C2 domain

  2. NM_001357523.1 → NP_001344452.1  centrosomal protein of 76 kDa isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC120410
    Conserved Domains (2) summary
    pfam01841
    Location:187 → 233
    Transglut_core; Transglutaminase-like superfamily
    pfam15627
    Location:1 → 80
    CEP76-C2; CEP76 C2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    67750034..67774425 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0VEJ0.1 GenPept UniProtKB/Swiss-Prot:Q0VEJ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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