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Mppe1 metallophosphoesterase 1 [ Mus musculus (house mouse) ]

Gene ID: 225651, updated on 5-Mar-2024

Summary

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Official Symbol
Mppe1provided by MGI
Official Full Name
metallophosphoesterase 1provided by MGI
Primary source
MGI:MGI:2661311
See related
Ensembl:ENSMUSG00000062526 AllianceGenome:MGI:2661311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pgap5
Summary
Predicted to enable metal ion binding activity and phosphoric diester hydrolase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in Golgi apparatus and nucleoplasm. Orthologous to human MPPE1 (metallophosphoesterase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 18.8), spleen adult (RPKM 10.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 E1; 18 39.9 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (67358119..67378901, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (67225043..67245830, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein, alpha stimulating, olfactory type Neighboring gene predicted gene, 23512 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:67372131-67372603 Neighboring gene charged multivesicular body protein 1B Neighboring gene STARR-positive B cell enhancer ABC_E9173 Neighboring gene STARR-seq mESC enhancer starr_44880 Neighboring gene STARR-positive B cell enhancer ABC_E7602 Neighboring gene STARR-positive B cell enhancer mm9_chr18:67448542-67448843 Neighboring gene STARR-seq mESC enhancer starr_44887 Neighboring gene predicted gene, 30321 Neighboring gene inositol monophosphatase 2 Neighboring gene RIKEN cDNA B430212C06 gene Neighboring gene STARR-positive B cell enhancer ABC_E10999 Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
metallophosphoesterase 1
Names
post-GPI attachment to proteins factor 5
NP_001344447.1
NP_766218.1
XP_011245209.1
XP_011245210.1
XP_011245211.1
XP_011245212.1
XP_011245213.1
XP_011245214.1
XP_011245215.1
XP_030106302.1
XP_030106303.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357518.1 → NP_001344447.1  metallophosphoesterase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140336, BM898884
    UniProtKB/Swiss-Prot
    Q3T9I6, Q3TYP9, Q3U4F5, Q80XL7, Q8BLU5
    Conserved Domains (1) summary
    cd08165
    Location:71 → 329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  2. NM_172630.3 → NP_766218.1  metallophosphoesterase 1 isoform 1

    See identical proteins and their annotated locations for NP_766218.1

    Status: VALIDATED

    Source sequence(s)
    AC140336, AK041262, BM898884
    Consensus CDS
    CCDS29319.1
    UniProtKB/Swiss-Prot
    Q80XL7
    Related
    ENSMUSP00000072808.4, ENSMUST00000073054.5
    Conserved Domains (1) summary
    cd08165
    Location:71 → 330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    67358119..67378901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011246910.4 → XP_011245212.1  metallophosphoesterase 1 isoform X2

    Conserved Domains (1) summary
    cd08165
    Location:71 → 352
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  2. XM_011246911.4 → XP_011245213.1  metallophosphoesterase 1 isoform X5

    See identical proteins and their annotated locations for XP_011245213.1

    Conserved Domains (1) summary
    cl13995
    Location:19 → 282
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  3. XM_011246907.4 → XP_011245209.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245209.1

    Conserved Domains (1) summary
    cd08165
    Location:71 → 353
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  4. XM_030250442.2 → XP_030106302.1  metallophosphoesterase 1 isoform X3

    Conserved Domains (1) summary
    cd08165
    Location:71 → 330
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  5. XM_030250443.2 → XP_030106303.1  metallophosphoesterase 1 isoform X4

    UniProtKB/Swiss-Prot
    Q3T9I6, Q3TYP9, Q3U4F5, Q80XL7, Q8BLU5
    Conserved Domains (1) summary
    cd08165
    Location:71 → 329
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  6. XM_011246913.4 → XP_011245215.1  metallophosphoesterase 1 isoform X5

    See identical proteins and their annotated locations for XP_011245215.1

    Conserved Domains (1) summary
    cl13995
    Location:19 → 282
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  7. XM_011246909.4 → XP_011245211.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245211.1

    Conserved Domains (1) summary
    cd08165
    Location:71 → 353
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

  8. XM_011246912.3 → XP_011245214.1  metallophosphoesterase 1 isoform X5

    See identical proteins and their annotated locations for XP_011245214.1

    Conserved Domains (1) summary
    cl13995
    Location:19 → 282
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  9. XM_011246908.3 → XP_011245210.1  metallophosphoesterase 1 isoform X1

    See identical proteins and their annotated locations for XP_011245210.1

    Conserved Domains (1) summary
    cd08165
    Location:71 → 353
    MPP_MPPE1; human MPPE1 and related proteins, metallophosphatase domain

RNA

  1. XR_003952516.1 RNA Sequence

  2. XR_003952517.1 RNA Sequence

  3. XR_003952518.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80XL7.1 GenPept UniProtKB/Swiss-Prot:Q80XL7

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