Ticam2 TIR domain containing adaptor molecule 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ticam2provided by MGI
Official Full Name: TIR domain containing adaptor molecule 2provided by MGI
Primary source: MGI:MGI:3040056
See related: Ensembl:ENSMUSG00000056130 AllianceGenome:MGI:3040056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TRAM; Tirp; Trif; TICAM-2; B430113A10
Summary: Enables phospholipid binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of interleukin-18-mediated signaling pathway; and response to interleukin-12. Acts upstream of or within defense response to virus and regulation of cytokine production. Located in endosome and plasma membrane. Is expressed in testis and ureter. Used to study Coronavirus infectious disease. Orthologous to several human genes including TMED7-TICAM2 (TMED7-TICAM2 readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 18 C; 18 24.65 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (46691298..46707600, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (46558231..46574533, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity.
Title: TRAM deletion attenuates monocyte exhaustion and alleviates sepsis severity.
The role of TRIF protein in regulating the proliferation and antigen presentation ability of myeloid dendritic cells through the ERK1/2 signaling pathway in chronic low-grade inflammation of intestinal mucosa mediated by flagellin-TLR5 complex signal.
Title: The role of TRIF protein in regulating the proliferation and antigen presentation ability of myeloid dendritic cells through the ERK1/2 signaling pathway in chronic low-grade inflammation of intestinal mucosa mediated by flagellin-TLR5 complex signal.
Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling.
Title: Pathogenic Leptospires Limit Dendritic Cell Activation Through Avoidance of TLR4 and TRIF Signaling.
TRAM-Related TLR4 Pathway Antagonized by IRAK-M Mediates the Expression of Adhesion/Coactivating Molecules on Low-Grade Inflammatory Monocytes.
Title: TRAM-Related TLR4 Pathway Antagonized by IRAK-M Mediates the Expression of Adhesion/Coactivating Molecules on Low-Grade Inflammatory Monocytes.
Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.
Title: Macrophage deletion of Noc4l triggers endosomal TLR4/TRIF signal and leads to insulin resistance.
SET8 participates in lipopolysaccharide-mediated BV2 cell inflammation via modulation of TICAM-2 expression.
Title: SET8 participates in lipopolysaccharide-mediated BV2 cell inflammation via modulation of TICAM-2 expression.
TICAM2-related pathway mediates neutrophil exhaustion.
Title: TICAM2-related pathway mediates neutrophil exhaustion.
TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells.
Title: TRIF deficiency protects non-obese diabetic mice from type 1 diabetes by modulating the gut microbiota and dendritic cells.
TLR3(-/-) and TRIF(-/-) mice presented higher parasite burdens, increased inflammatory lesions, and reduced production of interleukin 12p40, tumor necrosis factor, gamma interferon, and nitric oxide.
Title: Toll-Like Receptor 3-TRIF Pathway Activation by Neospora caninum RNA Enhances Infection Control in Mice.
Analysis of NF-kappaB activation caused by transient expression of proteins involved in the MyD88-dependent pathway in TLR signaling revealed that AKT1 suppressed signaling that occurs between activation of IKKbeta and that of NF-kappaB.
Title: AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner.

Submit: New GeneRIF Correction See all GeneRIFs (101)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Chemically induced (ENU) (3)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables interleukin-1 receptor binding	ISO Inferred from Sequence Orthology more info	PubMed
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info	PubMed
enables signaling adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in TRIF-dependent toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phagocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of chemokine (C-C motif) ligand 5 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-18-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-18-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type I interferon production	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within regulation of cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info	PubMed
involved_in response to interleukin-12	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 4 signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	ISO Inferred from Sequence Orthology more info
is_active_in endosome membrane	ISO Inferred from Sequence Orthology more info
part_of interleukin-1 receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TIR domain-containing adapter molecule 2

Names: TIR domain-containing adapter protein; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll-like receptor adaptor molecule 2; toll/interleukin-1 receptor domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173394.3 → NP_775570.1 TIR domain-containing adapter molecule 2

See identical proteins and their annotated locations for NP_775570.1

Status: VALIDATED

Source sequence(s)

AK080873, AK134103, BC099933

Consensus CDS

CCDS29232.1

UniProtKB/Swiss-Prot

Q3U996, Q8BJQ4

Related

ENSMUSP00000066239.4, ENSMUST00000070084.11

Conserved Domains (1) summary

cl23749
Location:78 → 178

TIR_2; TIR domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

46691298..46707600 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161115.1 → XP_036017008.1 TIR domain-containing adapter molecule 2 isoform X1

Conserved Domains (1) summary

cl23749
Location:97 → 188

TIR_2; TIR domain