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Rbm27 RNA binding motif protein 27 [ Mus musculus (house mouse) ]

Gene ID: 225432, updated on 11-Apr-2024

Summary

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Official Symbol
Rbm27provided by MGI
Official Full Name
RNA binding motif protein 27provided by MGI
Primary source
MGI:MGI:2147194
See related
Ensembl:ENSMUSG00000024491 AllianceGenome:MGI:2147194
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Psc1; mKIAA1311; A730010I06
Summary
Predicted to enable RNA binding activity. Predicted to be involved in mRNA processing. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; brain; and nose. Orthologous to human RBM27 (RNA binding motif protein 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 9.4), CNS E11.5 (RPKM 5.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B3; 18 22.45 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (42408386..42474607)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (42275205..42341542)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene leucyl-tRNA synthetase 1 Neighboring gene ribosomal protein S19, pseudogene 4 Neighboring gene STARR-positive B cell enhancer ABC_E494 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:42434622-42434731 Neighboring gene STARR-positive B cell enhancer ABC_E495 Neighboring gene predicted gene 4013 Neighboring gene STARR-seq mESC enhancer starr_44436 Neighboring gene STARR-seq mESC enhancer starr_44438 Neighboring gene STARR-seq mESC enhancer starr_44439 Neighboring gene POU domain, class 4, transcription factor 3 Neighboring gene predicted gene, 31438

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A family of RS domain proteins with novel subcellular localization and trafficking. Kavanagh SJ, et al. Nucleic Acids Res, 2005. PMID 15741184, Free PMC Article
  2. Transient pluripotent cell populations during primitive ectoderm formation: correlation of in vivo and in vitro pluripotent cell development. Pelton TA, et al. J Cell Sci, 2002 Jan 15. PMID 11839785
  3. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Jones MR, et al. Front Genet, 2018. PMID 30728831, Free PMC Article
  4. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 27
Names
peri implantation stem cell 1
peri-implantation stem cell protein 1
periimplantation stem cell 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001408209.1 → NP_001395138.1  RNA-binding protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC125110
    UniProtKB/Swiss-Prot
    E9QM85, Q5SFM8, Q6ZPT9, Q7TQK8, Q8C2X5, Q8C9A5
    Related
    ENSMUSP00000158063.2, ENSMUST00000236240.2

  2. NM_001408210.1 → NP_001395139.1  RNA-binding protein 27 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC125110

  3. NM_001408211.1 → NP_001395140.1  RNA-binding protein 27 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC125110

  4. NM_172626.3 → NP_766214.2  RNA-binding protein 27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC125110
    Consensus CDS
    CCDS50267.1
    UniProtKB/Swiss-Prot
    Q5SFM8
    Related
    ENSMUSP00000089540.6, ENSMUST00000091920.6
    Conserved Domains (4) summary
    pfam00642
    Location:277 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam16046
    Location:694 → 828
    FAM76; FAM76 protein
    cl02562
    Location:7 → 72
    PWI; PWI domain
    cl17169
    Location:544 → 619
    RRM_SF; RNA recognition motif (RRM) superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    42408386..42474607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006525864.4 → XP_006525927.1  RNA-binding protein 27 isoform X2

    Conserved Domains (6) summary
    cd12517
    Location:599 → 674
    RRM_RBM27; RNA recognition motif of vertebrate RNA-binding protein 27 (RBM27)
    pfam00642
    Location:277 → 299
    zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
    pfam15991
    Location:661 → 773
    G_path_suppress; G-protein pathway suppressor
    cl02562
    Location:7 → 72
    PWI; PWI domain
    cl17169
    Location:931 → 973
    RRM_SF; RNA recognition motif (RRM) superfamily
    cl19219
    Location:763 → 844
    FapA; Flagellar Assembly Protein A

  2. XM_017317887.3 → XP_017173376.1  RNA-binding protein 27 isoform X3

    Conserved Domains (4) summary
    PRK03918
    Location:708 → 839
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam15991
    Location:563 → 727
    G_path_suppress; G-protein pathway suppressor
    cl02562
    Location:7 → 72
    PWI; PWI domain
    cl17169
    Location:501 → 576
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SFM8.3 GenPept UniProtKB/Swiss-Prot:Q5SFM8

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