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Etf1 eukaryotic translation termination factor 1 [ Mus musculus (house mouse) ]

Gene ID: 225363, updated on 21-Apr-2024

Summary

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Official Symbol
Etf1provided by MGI
Official Full Name
eukaryotic translation termination factor 1provided by MGI
Primary source
MGI:MGI:2385071
See related
Ensembl:ENSMUSG00000024360 AllianceGenome:MGI:2385071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERF; ERF1; TB3-1; SUP45L1; D6Ertd109e
Summary
Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation and translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Is expressed in central nervous system and retina. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 27.4), CNS E11.5 (RPKM 25.7) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.78 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35035838..35065060, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34902785..34932008, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:35020809-35020992 Neighboring gene early growth response 1 Neighboring gene predicted gene, 54018 Neighboring gene STARR-positive B cell enhancer ABC_E964 Neighboring gene heat shock protein 9 Neighboring gene predicted gene, 22200 Neighboring gene predicted gene, 26109

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination. Orlova M, et al. Cell, 2003 Oct 31. PMID 14636559
  2. Stop codon selection in eukaryotic translation termination: comparison of the discriminating potential between human and ciliate eRF1s. Chavatte L, et al. EMBO J, 2003 Apr 1. PMID 12660170, Free PMC Article
  3. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms. Stoddart A, et al. Haematologica, 2016 Jun. PMID 26944478, Free PMC Article
  4. In vitro reconstitution of eukaryotic translation reveals cooperativity between release factors eRF1 and eRF3. Alkalaeva EZ, et al. Cell, 2006 Jun 16. PMID 16777602
  5. CFIm-mediated alternative polyadenylation safeguards the development of mammalian pre-implantation embryos. Li N, et al. Stem Cell Reports, 2023 Jan 10. PMID 36563685, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms
    Title: Retroviral insertional mutagenesis identifies the del(5q) genes, CXXC5, TIFAB and ETF1, as well as the Wnt pathway, as potential targets in del(5q) myeloid neoplasms.
  2. Reverse Transcriptase enhances suppression of termination and that the interaction of RT with eRF1 is required for an appropriate level of translational readthrough.
    Title: Reverse transcriptase of Moloney murine leukemia virus binds to eukaryotic release factor 1 to modulate suppression of translational termination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC18745

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables aminoacyl-tRNA hydrolase activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity ISO
Inferred from Sequence Orthology
more info
  
enables translation release factor activity, codon specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation termination factor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translational termination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process, nonsense-mediated decay IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein methylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in regulation of translational termination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within translational termination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
part_of translation release factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of translation release factor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
eukaryotic peptide chain release factor subunit 1
Names
eukaryotic release factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144866.3 → NP_659115.3  eukaryotic peptide chain release factor subunit 1

    See identical proteins and their annotated locations for NP_659115.3

    Status: VALIDATED

    Source sequence(s)
    AC114820, AI844751, AK169345, BY238984
    Consensus CDS
    CCDS29137.1
    UniProtKB/Swiss-Prot
    Q3TPZ6, Q8BWY3, Q91VH9
    UniProtKB/TrEMBL
    Q3TDF8, Q3TF02, Q3TL10
    Related
    ENSMUSP00000025218.8, ENSMUST00000025218.8
    Conserved Domains (1) summary
    COG1503
    Location:11 → 419
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35035838..35065060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250436.2 → XP_030106296.1  eukaryotic peptide chain release factor subunit 1 isoform X1

    UniProtKB/TrEMBL
    Q3U6V5
    Conserved Domains (1) summary
    COG1503
    Location:1 → 386
    eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BWY3.4 GenPept UniProtKB/Swiss-Prot:Q8BWY3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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